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001-es BibID:	BIBFORM065240
Első szerző:	Bertalan Rita
Cím:	Overrepresentation of BclI polymorphism of the glucocorticoid receptor gene in pregnant women with HELLP syndrome / Rita Bertalan, Attila Patocs, Balint Nagy, Zoltan Derzsy, Nora Gullai, Agnes Szappanos, Janos Rigo Jr., Karoly Racz
Dátum:	2009
ISSN:	0009-8981
Megjegyzések:	BACKGROUND:Because the pathological background of preeclampsia and its severe variant, HELLP syndrome (hemolysis, elevated liver enzymes and low platelet counts) appears to involve a pathological maternal-fetal immune adaptation, we examined whether any association could exist between these disorders and polymorphisms of the glucocorticoid receptor (GR) gene.METHODS:The BclI, N363S, and ER22/23EK polymorphisms of the GR gene were determined in 300 healthy pregnant women, 150 pregnant women with severe preeclampsia including 17 pregnant women with HELLP syndrome.RESULTS:There were no significant differences in carrier and allelic frequencies of the N363S and ER22/23EK polymorphisms between healthy pregnant women and those with severe preeclampsia. However, the allelic and carrier frequencies of the BclI polymorphism were significantly higher in women with HELLP syndrome compared to healthy pregnant women (p=0.004; Odds ratio, 2.89) and to those with severe preeclampsia (p=0.013; Odds ratio, 2.56).CONCLUSION:Our observations suggest that among pregnant women, the BclI polymorphism is associated with the development of HELLP syndrome, but not that of severe preeclampsia. Since preeclampsia and HELLP syndrome develop exclusively in human, it seems particularly interesting that alignment analysis of DNA sequences obtained from databases indicated the absence of the BclI site in 6 animal vertebral species.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban BclI polymorphism Glucocorticoid pregnancy
Megjelenés:	Clinica Chimica Acta. - 405 : 1-2 (2009), p. 148-152. -
További szerzők:	Patócs Attila Nagy Bálint (1956-) (molekuláris genetikus) Derzsy Zoltán Gullai Nóra Szappanos Ágnes Rigó János (1958-) (szülész-nőgyógyász) Rácz Károly (Budapest)
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001-es BibID:	BIBFORM073617
Első szerző:	Gullai Nóra
Cím:	Evaluation of a rapid and simple placental growth factor test in hypertensive disorders of pregnancy / Nóra Gullai, Balázs Stenczer, Attila Molvarec, Gergely Fügedi, Zoltán Veresh, Bálint Nagy, János Rigó Jr.
Dátum:	2013
ISSN:	0916-9636
Megjegyzések:	The aim of this study was to investigate the diagnostic accuracy of the Triage placental growth factor (PlGF) assay, together with its prognostic efficiency in determining the need for preterm delivery in all forms of hypertensive disorders of pregnancy. A total of 130 pregnant women with a diagnosis of preeclampsia (PE: 23), HELLP syndrome (20), superimposed preeclampsia (SIPE: 17), chronic hypertension (CHT: 25), gestational hypertension (GHT: 18) and 27 normotensive pregnant controls were enrolled in this case-control study. A single blood sample was taken between 22 and 34 weeks of gestation, and the plasma was analyzed for PlGF using the Alere Triage PlGF assay. The PlGF levels found in all hypertensive disorder groups differed significantly from those observed in controls. There was a highly significant difference in PlGF concentrations between women with a pregnancy duration <35 weeks and controls. Using a gestational age-dependent threshold of 5% of normal, a positive PlGF test predicted delivery before 35 weeks in 93.7% of hypertensive women and delivery before 37 weeks in 90.5% of hypertensive women. A positive PlGF test identified the following proportions of hypertensive patients: 95.7% (PE), 95.0% (HELLP syndrome), 82.4% (SIPE), 60.0% (CHT) and 44.4% (GHT). A positive PlGF test was associated with a significantly shorter duration of pregnancy (hazard ratio of 3.43 adjusted for the gestational age at the time of sample collection and hypertension with proteinuria). In conclusion, PlGF concentrations are significantly lower in all hypertensive disorders. A positive test using the Triage PlGF assay at 22-34 weeks of gestation predicts delivery before 37 weeks in women with both proteinuric and non-proteinuric hypertensive disorders of pregnancy.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban hypertension pregnancy placental growth
Megjelenés:	Hypertension Research 36 : 5 (2013), p. 457-462. -
További szerzők:	Stenczer Balázs Molvarec Attila (szülész-nőgyógyász) Fügedi Gergely Veresh Zoltán Nagy Bálint (1956-) (molekuláris genetikus) Rigó János (1958-) (szülész-nőgyógyász)
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001-es BibID:	BIBFORM065219
Első szerző:	Molvarec Attila (szülész-nőgyógyász)
Cím:	Comparison of placental growth factor and fetal flow Doppler ultrasonography to identify fetal adverse outcomes in women with hypertensive disorders of pregnancy : an observational study / Attila Molvarec, Nóra Gullai, Balázs Stenczer, Gergely Fügedi, Bálint Nagy, János Rigó Jr.
Dátum:	2013
Megjegyzések:	Background:Hypertensive disorders of pregnancy and intrauterine growth restriction (IUGR) are leading causes ofmaternal and perinatal morbidity and mortality. Failure to detect intrauterine growth restriction in women at highrisk has been highlighted as a significant avoidable cause of serious fetal outcome. In this observational study wecompare fetal flow using Doppler ultrasonography with a new test for placental growth factor (PlGF) to predictfetal adverse events.Methods:Eighty-nine women with hypertensive disorders of pregnancy (24 with chronic hypertension, 17 withgestational hypertension, 12 with HELLP syndrome, 19 with preeclampsia and 17 with superimposed preeclampsia)were enrolled. A single maternal blood sample to measure free PlGF (Alere Triage) taken before 35 weeks ofpregnancy was compared to the last Doppler ultrasound measurement of fetal flow before delivery. PlGF wasclassified as normal (PlGF?100 pg/ml), low (12<PlGF<100) or very low (PlGF?12 pg/ml). A positive test for abnormalfetal flow was defined as either signs of centralisation of the fetal circulation or diastolic block or reverse flow in theumbilical artery or descending aorta; this was a criterion for delivery. Fetal outcomes were intrauterine growthrestriction and birth before 37 weeks of pregnancy.Results:In total 61/89 women had a preterm birth and 22 infants had IUGR. Of those who delivered preterm,20/20 women with abnormal fetal flow and 36/41 (87.8%) women with normal fetal flow had low or very low PlGF.Of those infants with IUGR, 22/22 had low or very low maternal PlGF and 10/22 had abnormal fetal flow.Conclusions:PlGF may provide useful information before 35th gestational week to identify fetuses requiring urgentdelivery, and those at risk of later adverse outcomes not identified by fetal flow Doppler ultrasonography.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban hypertension placental growth factor PlGF IUGR preeclampsia
Megjelenés:	BMC Pregnancy and Child Birth 13 (2013), p. 1-7. -
További szerzők:	Gullai Nóra Stenczer Balázs Fügedi Gergely Nagy Bálint (1956-) (molekuláris genetikus) Rigó János (1958-) (szülész-nőgyógyász)
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