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001-es BibID:BIBFORM065310
Első szerző:Than Nándor Gábor (szülész-nőgyógyász)
Cím:Placental Protein 13 (galectin-13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm preeclampsia and HELLP syndrome / Nandor Gabor Than, Omar Abdul-Rahman, Rita Magenheim, Balint Nagy, Tibor Fule, Beata Hargitai, Marei Sammar, Petronella Hupuczi, Adi L. Tarca, Gabor Szabo, Ilona Kovalszky, Hamutal Meiri, Istvan Sziller, Janos Rigo Jr., Roberto Romero, Zoltan Papp
Dátum:2008
ISSN:0945-6317
Megjegyzések:Placental Protein 13 (PP13) is a galectin expressed by the syncytiotrophoblast. Women whosubsequently develop preterm preeclampsia have low first trimester maternal serum PP13concentrations. This study revealed that third trimester maternal serum PP13 concentration increasedwith gestational age in normal pregnancies (p<0.0001), and it was significantly higher in womenpresenting with preterm preeclampsia (p=0.02) and HELLP syndrome (p=0.01) than in pretermcontrols. Conversely, placental PP13 mRNA (p=0.03) and protein, as well as cytoplasmic PP13staining of the syncytiotrophoblast (p<0.05) was decreased in these pathological pregnanciescompared to controls. No differences in placental expression and serum concentrations of PP13 werefound at term between patients with preeclampsia and control women. In contrast, theimmunoreactivity of the syncytiotrophoblast microvillous membrane was stronger in both term andpreterm preeclampsia and HELLP syndrome than in controls. Moreover, large syncytial cytoplasmprotrusions, membrane blebs and shed microparticles strongly stained for PP13 in preeclampsia andHELLP syndrome. In conclusion, parallel to its decreased placental expression, an augmentedmembrane shedding of PP13 contributes to the increased third trimester maternal serum PP13concentrations in women with preterm preeclampsia and HELLP syndrome
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
placental
protein 13
galectin-13
expression
Megjelenés:Virchows Archiv. - 453 : 4 (2008), p. 387-400. -
További szerzők:Abdul-Rahman, Omar Magenheim Rita Nagy Bálint (1956-) (molekuláris genetikus) Füle Tibor Hargitai Beáta Sammar, Marei Hupuczi Petronella (anaesthesiológus) Tarca, Adi Laurentiu Szabó Gábor (budapesti orvos) Kovalszky Ilona Meiri, Hamutal Sziller István (szülész-nőgyógyász szakorvos) Rigó János (1958-) (szülész-nőgyógyász) Romero, Roberto Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus)
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001-es BibID:BIBFORM065231
Első szerző:Várkonyi Tibor
Cím:Microarray Profiling Reveals That Placental Transcriptomes of Early-onset HELLP Syndrome and Preeclampsia Are Similar / Várkonyi T., Nagy B., Füle T., Tarca A. L., Karászi K., Schönléber J., Hupuczi P., Mihalik N., Kovalszky I., Rigó J., Meiri H., Papp Z., Romero R., Than N. G.
Dátum:2011
ISSN:0143-4004
Megjegyzések:The involvement of the placenta in the pathogenesis of preeclampsia and HELLP syndrome is well established, and placental lesions are also similar in these two syndromes. Here we aimed to examine the placental transcriptome and to identify candidate biomarkers in early-onset preeclampsia and HELLP syndrome.MethodsPlacental specimens were obtained at C-sections from women with early-onset preeclampsia and HELLP syndrome, and from controls who delivered preterm or at term. After histopathological examination, fresh-frozen placental specimens were used for microarray profiling and validation by qRT-PCR. Differential expression was analysed using log?linear models while adjusting for gestational age. Gene ontology and pathway analyses were used to interpret gene expression changes. Tissue microarrays were constructed from paraffin-embedded placental specimens and immunostained.ResultsPlacental gene expression was gestational age-dependent among preterm and term controls. Out of the 350 differentially expressed genes in preeclampsia and 554 genes in HELLP syndrome, 224 genes (including LEP, CGB, LHB, INHA, SIGLEC6, PAPPA2, TREM1, and FLT1) changed in the same direction (elevated or reduced) in both syndromes. Many of these encode proteins that have been implicated as biomarkers for preeclampsia. Enrichment analyses revealed similar biological processes, cellular compartments and biological pathways enriched in early-onset preeclampsia and HELLP syndrome; however, some processes and pathways (e.g., cytokine?cytokine receptor interaction) were over-represented only in HELLP syndrome.ConclusionHigh-throughput transcriptional and tissue microarray expression profiling revealed that placental transcriptomes of early-onset preeclampsia and HELLP syndrome largely overlap, underlying a potential common cause and pathophysiologic processes in these syndromes. However, gene expression changes may also suggest a more severe placental pathology and pronounced inflammatory response in HELLP syndrome than in preeclampsia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
microarray
preeclampsia
transcriptomes
early-onset
Megjelenés:Placenta 32 (2011), p. S21-29. -
További szerzők:Nagy Bálint (1956-) (molekuláris genetikus) Füle Tibor Tarca, Adi Laurentiu Karászi Katalin Schönléber J. Hupuczi Petronella (anaesthesiológus) Mihalik N. Kovalszky Ilona Rigó János (1958-) (szülész-nőgyógyász) Meiri, Hamutal Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus) Romero, Roberto Than Nándor Gábor (szülész-nőgyógyász)
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