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001-es BibID:	BIBFORM065209
Első szerző:	Magyar Zsófia
Cím:	Expression of VEGF in Neonatal Urinary Obstruction : does Expression of VEGF Predict Hydronephrosis? / Zsófia Magyar, Julianna Schönleber, Miklós Romics, Ervin Hruby, Bálint Nagy, Bálint Sulya F., Artúr Beke, Ágnes Harmath, Judit Jeager, János Rigó jr., Éva Görbe
Dátum:	2015
ISSN:	1234-1010
Megjegyzések:	In animal studies, the inhibition of VEGF activity results in high mortality and impaired renal and glomerular development. Mechanical stimuli, like mechanical stretch in respiratory and circulatory systems, results in an elevated expression of VEGF. In animal models, the experimental urinary obstruction is associated with stretching of tubular cells and activations of the renin-angiotensin system. This results in the upregulation of vascular endothelial growth factor (VEGF) and TNF-alfa.Material/Methods:Tissue samples from urinary tract obstruction were collected and immunohistochemistry was performed in 14 patients (average age: 7.1?4.1 years). The control histology group consisted of ureteropelvic junction tissue from 10 fetuses after midtrimester artificial abortion. The fetuses did not have any failure at ultrasound screening and pathological examination. The mean gestational age was 20.6 weeks of gestation (?2.2SD). Expression of VEGF was detected with immunohistochemistry method.Results:Expression of VEGF was found in varying intensity in the submucosa and subserosa layers, but only in the test tissue (placental tissue). The tissue of the patients with urinary obstruction and the tissue of the fetal ureteropelvic junction without urinary obstruction were negative for expression of VEGF. The repeated examination showed negative cells and no color staining.Conclusions:The pressure due to congenital urogenital obstruction resulting in mechanical stress in cells did not increase the expression of VEGF in young children in our study. To find a correlation between urogenital tract obstruction and increased expression of VEGF, we need to perform more examinations because the connection may be of therapeutic significance.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban endothelial growth factor urinary tract Hydronephros
Megjelenés:	Medical Science Monitor 21 (2015), p. 1319-1323. -
További szerzők:	Schönléber J. Romics Miklós Hruby Ervin Nagy Bálint (1956-) (molekuláris genetikus) Sulya Bálint F. Beke Artúr (szülész-nőgyógyász) Harmath Ágnes Jeager Judit Rigó János (1958-) (szülész-nőgyógyász) Görbe Éva
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM065231
Első szerző:	Várkonyi Tibor
Cím:	Microarray Profiling Reveals That Placental Transcriptomes of Early-onset HELLP Syndrome and Preeclampsia Are Similar / Várkonyi T., Nagy B., Füle T., Tarca A. L., Karászi K., Schönléber J., Hupuczi P., Mihalik N., Kovalszky I., Rigó J., Meiri H., Papp Z., Romero R., Than N. G.
Dátum:	2011
ISSN:	0143-4004
Megjegyzések:	The involvement of the placenta in the pathogenesis of preeclampsia and HELLP syndrome is well established, and placental lesions are also similar in these two syndromes. Here we aimed to examine the placental transcriptome and to identify candidate biomarkers in early-onset preeclampsia and HELLP syndrome.MethodsPlacental specimens were obtained at C-sections from women with early-onset preeclampsia and HELLP syndrome, and from controls who delivered preterm or at term. After histopathological examination, fresh-frozen placental specimens were used for microarray profiling and validation by qRT-PCR. Differential expression was analysed using log?linear models while adjusting for gestational age. Gene ontology and pathway analyses were used to interpret gene expression changes. Tissue microarrays were constructed from paraffin-embedded placental specimens and immunostained.ResultsPlacental gene expression was gestational age-dependent among preterm and term controls. Out of the 350 differentially expressed genes in preeclampsia and 554 genes in HELLP syndrome, 224 genes (including LEP, CGB, LHB, INHA, SIGLEC6, PAPPA2, TREM1, and FLT1) changed in the same direction (elevated or reduced) in both syndromes. Many of these encode proteins that have been implicated as biomarkers for preeclampsia. Enrichment analyses revealed similar biological processes, cellular compartments and biological pathways enriched in early-onset preeclampsia and HELLP syndrome; however, some processes and pathways (e.g., cytokine?cytokine receptor interaction) were over-represented only in HELLP syndrome.ConclusionHigh-throughput transcriptional and tissue microarray expression profiling revealed that placental transcriptomes of early-onset preeclampsia and HELLP syndrome largely overlap, underlying a potential common cause and pathophysiologic processes in these syndromes. However, gene expression changes may also suggest a more severe placental pathology and pronounced inflammatory response in HELLP syndrome than in preeclampsia.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban microarray preeclampsia transcriptomes early-onset
Megjelenés:	Placenta 32 (2011), p. S21-29. -
További szerzők:	Nagy Bálint (1956-) (molekuláris genetikus) Füle Tibor Tarca, Adi Laurentiu Karászi Katalin Schönléber J. Hupuczi Petronella (anaesthesiológus) Mihalik N. Kovalszky Ilona Rigó János (1958-) (szülész-nőgyógyász) Meiri, Hamutal Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus) Romero, Roberto Than Nándor Gábor (szülész-nőgyógyász)
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