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001-es BibID:	BIBFORM074834
Első szerző:	Savlı, Hakan
Cím:	Bortezomib and Arsenic Trioxide Activity on a Myelodysplastic Cell Line (P39) : a Gene Expression Study / Hakan Savlı, Sara Galimberti, Deniz Sünnetçi, Martina Canestraro, Giuseppe Palumbo, Balint Nagy, Francesco Di Raimondo, Mario Petrini
Dátum:	2015
ISSN:	1300-7777
Megjegyzések:	NTRODUCTION:We aimed to understand the molecular pathways affected by bortezomib and arsenic trioxide treatment on myelomonocytoid cell line P39.METHODS:Oligonucleotide microarray platforms were used for gene expression and pathway analysis. Confirmation studies were performed using quantitative real time PCR.RESULTS:Bortezomib treatment has shown upregulated DIABLO and NF-?BIB (a NF-?B inhibitor) and downregulated NF-?B1, NF-?B2, and BIRC1 gene expressions. Combination treatment of the two compounds showed gene expression deregulations in concordance by the results of single bortezomib treatment. Especially, P53 was a pathway more significantly modified and a gene network centralized around the beta estradiol gene. Beta estradiol, BRCA2, and FOXA1 genes were remarkable deregulations in our findings.DISCUSSION AND CONCLUSION:Results support the suggestions about possible use of proteasome inhibitors in the treatment of high-risk myelodysplastic syndrome (MDS). NF-?B was observed as an important modulator in leukemic transformation of MDS.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban bortezomib gene expression myelodyplastic
Megjelenés:	Turkish Journal of Hematology. - 32 : 3 (2015), p. 206-212. -
További szerzők:	Galimberti, Sara Sünnetçi, Deniz Canesastraro, Martina Palumbo, Giuseppe Alberto Nagy Bálint (1956-) (molekuláris genetikus) Raimondo, Francesco Di Petrini, Mario
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