Találati lista | Tudóstér

001-es BibID:	BIBFORM074852
Első szerző:	Myllykangas, Samuel
Cím:	Helicobacter pylori infection activates FOS and stress-response genes and alters expression of genes in gastric cancer-specific loci / Samuel Myllykangas, Outi Monni, Bálint Nagy, Hilpi Rautelin, Sakari Knuutila
Dátum:	2004
ISSN:	1045-2257
Megjegyzések:	We studied human gene expression changes caused by Helicobacter pylori infection by using an in vitro model and 13k cDNA microarrays. A gastric cancer cell line was infected with H. pylori strain NCTC 11637. H. pylori infection was found to induce differential expression of genes in chromosomal locations known to contain frequent chromosomal aberrations and gene mutations specific to gastric cancer. Based on the results of time series experiments, the primary transcription target of the infection seemed to be FOS, the expression of which significantly increased after H. pylori infection. H. pylori infection also activated transcription of several stress-response genes. H. pylori infection may predispose the host cell to DNA damage in the chromosomal locations specific to gastric cancer by activating transcription and promoting histone removal from these sites, thus exposing its target DNA to mutations.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Helicobacter pylori FOS gene expression
Megjelenés:	Genes Chromosomes & Cancer. - 40 : 4 (2004), p. 334-341. -
További szerzők:	Monni, Outi Nagy Bálint (1956-) (molekuláris genetikus) Rautelin, Hilpi Knuutila, Sakari
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: