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001-es BibID:	BIBFORM061878
Első szerző:	Becs Gergely
Cím:	Pharmacological induction of ferritin prevents osteoblastic transformation of smooth muscle cells / Gergely Becs, Abolfazl Zarjou, Anupam Agarwal, Katalin Éva Kovács, Ádám Becs, Mónika Nyitrai, Enikő Balogh, Emese Bányai, John W. Eaton, Paolo Arosio, Maura Poli, Viktória Jeney, József Balla, György Balla
Dátum:	2016
ISSN:	1582-1838
Megjegyzések:	Vascular calcification is a frequent complication of atherosclerosis, diabetes and chronic kidney disease. In the latter group of patients, calcification is commonly seen in tunica media where smooth muscle cells (SMC) undergo osteoblastic transformation. Risk factors such as elevated phosphorus levels and vitamin D3 analogues have been identified. In the light of earlier observations by our group and others, we sought to inhibit SMC calcification via induction of ferritin. Human aortic SMC were cultured using b-glycerophosphate with activated vitamin D3, or inorganic phosphate with calcium, and induction of alkaline phosphatase (ALP) and osteocalcin as well as accumulation of calcium were used to monitor osteoblastic transformation. In addition, to examine the role of vitamin D3 analogues, plasma samples from patients on haemodialysis who had received calcitriol or paricalcitol were tested for their tendency to induce calcification of SMC. Addition of exogenous ferritin mitigates the transformation of SMC into osteoblast-like cells. Importantly, pharmacological induction of heavy chain ferritin by 3H-1,2-Dithiole-3-thione was able to inhibit the SMC transition into osteoblast-like cells and calcification of extracellular matrix. Plasma samples collected from patients after the administration of activated vitamin D3 caused significantly increased ALP activity in SMC compared to the samples drawn prior to activated vitamin D3 and here, again induction of ferritin diminished the osteoblastic transformation. Our data suggests that pharmacological induction of ferritin prevents osteoblastic transformation of SMC. Hence, utilization of such agents that will cause enhanced ferritin synthesis may have important clinical applications in prevention of vascular calcification.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban ferritin ferroxidase activity [béta]-glycerophosphate vascular calcification vitamin D3
Megjelenés:	Journal Of Cellular And Molecular Medicine. - 20 : 2 (2016), p. 217-230. -
További szerzők:	Zarjou, Abolfazl (1979-) (kutató orvos) Agarwal, Anupam Sikura Katalin Éva (1985-) (biológus) Becs Ádám Nyitrai Mónika Balogh Enikő (1987-) (molekuláris biológus) Bányai Emese (1984-) (orvos) Eaton, John W. Arosio, Paolo Poli, Maura Jeney Viktória (1971-) (vegyész, kémia tanár) Balla József (1959-) (belgyógyász, nephrológus) Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0045 TÁMOP Belgyógyászat Kutatócsoport K-112333(B.J.) OTKA MTA-DE MTA Vascularis Biológia, Thrombosis-Haemostasis Kutatócsoport
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001-es BibID:	BIBFORM067244
Első szerző:	Sikura Katalin Éva (biológus)
Cím:	Calcification process is inhibited by ferritin system in human heart valves / Kovács Katalin Éva, Jeney Viktória, Szerafin Tamás, Balla József
Dátum:	2013
Megjegyzések:	The calcification process have a major role in the pathophysiology of cardiovascular diseases. The calcification of heart valve in elderly often require surgical intervention. Actually, the calcification is an active process, in which the osteoblastic transformation of valve cells occur, similarly in the human smooth muscle cells during vascular calcification. Ferritin/ferroxidase system plays an important role in preventing the calcification process. Our laboratory have previously demonstrated that the induction of ferritin/ferroxidase system inhibited calcification of the smooth muscle cells from human aorta. We hypothesize that calcification of interstitial cells derived from the tissue of heart valve can be inhibited by the activation of ferritin/ferroxidase system.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok konferenciacikk atherosclerosis szívbillentyű
Megjelenés:	Cardiologia Hungarica 43 (2013), p. H12. -
További szerzők:	Jeney Viktória (1971-) (vegyész, kémia tanár) Szerafin Tamás (1960-) (szívsebész, mellkassebész) Balla József (1959-) (belgyógyász, nephrológus)
Pályázati támogatás:	MTA-DE MTA Vascularis Biológia, Thrombosis-Haemostasis Kutatócsoport
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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