CCL

Összesen 1 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM065777
Első szerző:Lövey Katalin
Cím:Fat Necrosis After Partial-Breast Irradiation With Brachytherapy or Electron Irradiation Versus Standard Whole-Breast Radiotherapy : 4-Year Results of a Randomized Trial / Lövey Katalin, Fodor János, Major Tibor, Szabó Éva, Orosz Zsolt, Sulyok Zoltán, Jánváry Levente, Fröhlich Georgina, Kásler Miklós, Polgár Csaba
Dátum:2007
ISSN:0360-3016
Megjegyzések:Purpose: To examine the incidence and clinical relevance of fat necrosis after accelerated partial-breast irradiation(PBI) using interstitial high-dose-rate brachytherapy (HDR-BT) in comparison with partial-breast electronirradiation (ELE) and whole-breast irradiation (WBI).Methods and Materials: Between 1998 and 2004, 258 early-stage breast cancer patients were randomized to receive50 Gy WBI (n = 130) or PBI (n = 128). The latter consisted of either 7 5.2 Gy HDR-BT (n = 88) or 50Gy ELE (n = 40). The incidence of fat necrosis, its impact on cosmetic outcome, accompanying radiologic features,and clinical symptoms were evaluated.Results: The 4-year actuarial rate of fat necrosis was 31.1% for all patients, and 31.9%, 36.5%, and 17.7% afterWBI, HDR-BT and ELE, respectively (pWBI/HDR-BT = 0.26; pWBI/ELE = 0.11; pELE/HDR-BT = 0.025). The respectiverate of asymptomatic fat necrosis was 20.2%, 25.3%, and 10% of patients. The incidence of symptomatic fatnecrosis was not significantly different after WBI (8.5%), HDR-BT (11.4%), and ELE (7.5%). Symptomatic fatnecrosis was significantly associated with a worse cosmetic outcome, whereas asymptomatic fat necrosis wasnot. Fat necrosis was detectable with mammography and/or ultrasound in each case. Additional imagingexaminations were required in 21% of cases and aspiration cytology in 42%.Conclusions: Asymptomatic fat necrosis is a common adverse event of breast-conserving therapy, having nosignificant clinical relevance in the majority of the cases. The incidence of both symptomatic and asymptomaticfat necrosis is similar after conventional WBI and accelerated partial-breast HDR-BT.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:International Journal Of Radiation Oncology Biology Physics 69 : 3 (2007), p. 724-731. -
További szerzők:Fodor János (onkológus) Major Tibor (1970-) (biofizikus) Szabó Éva Orosz Zsolt (1954-) (pathológus) Sulyok Zoltán Jánváry Zsolt Levente (1977-) (orvos) Fröhlich Georgina Kásler Miklós Polgár Csaba
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1