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001-es BibID:	BIBFORM096247
035-os BibID:	(cikkazonosító)1415 (WOS)000699319500001 (Scopus)85114236612
Első szerző:	Singlár Zoltán (biotechnológus)
Cím:	Assessing the Potential of Nutraceuticals as Geroprotectors on Muscle Performance and Cognition in Aging Mice / Zoltán Singlár, Péter Szentesi, János Fodor, Ágnes Angyal, László Csernoch, Mónika Sztretye
Dátum:	2021
ISSN:	2076-3921
Megjegyzések:	Aging and frailty are associated with a decline in muscle force generation, which is a direct consequence of reduced muscle quantity and quality. Among the leading contributors to aging is the generation of reactive oxygen species, the byproducts of terminal oxidation. Their negative effects can be moderated via antioxidant supplementation. Krill oil and astaxanthin (AX) are nutraceuticals with a variety of health promoting, geroprotective, anti-inflammatory, anti-diabetic and anti-fatigue effects. In this work, we examined the functional effects of these two nutraceutical agents supplemented via pelleted chow in aging mice by examining in vivo and in vitro skeletal muscle function, along with aspects of intracellular and mitochondrial calcium homeostasis, as well as cognition and spatial memory. AX diet regimen limited weight gain compared to the control group; however, this phenomenon was not accompanied by muscle tissue mass decline. On the other hand, both AX and krill oil supplementation increased force production without altering calcium homeostasis during excitation-contraction coupling mechanism or mitochondrial calcium uptake processes. We also provide evidence of improved spatial memory and learning ability in aging mice because of krill oil supplementation. Taken together, our data favors the application of antioxidant nutraceuticals as geroprotectors to improve cognition and healthy aging by virtue of improved skeletal muscle force production.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk skeletal muscle calcium homeostasis muscle performance excitation-contraction coupling astaxanthin krill oil nutraceutical cognition mitochondrial calcium aging
Megjelenés:	Antioxidants. - 10 : 9 (2021), p. 1415. -
További szerzők:	Szentesi Péter (1967-) (élettanász) Fodor János (1973-) (élettanász, biotechnológus) Angyal Ágnes (1987-) (molekuláris biológus) Csernoch László (1961-) (élettanász) Sztretye Mónika (1981-) (élettanász, elektrofiziológus)
Pályázati támogatás:	TKP2020-IKA-04 Egyéb 2020-4.1.1-TKP2020 Egyéb PD-128370 Egyéb GINOP-2.3.4-15-2016-00002 GINOP EFOP-3.6.3-VEKOP-16-2017-00009 EFOP OpenA/DEENK/230/2021 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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