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001-es BibID:	BIBFORM105360
035-os BibID:	(WoS)000894986300001 (Scopus)85143521697
Első szerző:	Herman Tünde (orvos)
Cím:	Impact of endocrine disorders on IVF outcomes : results from a large, single-centre, prospective study / T. Herman, Sz. Csehely, M. Orosz, H. P. Bhattoa, T. Deli, P. Török, A. S. Laganà, V. Chiantera, A. Jakab
Dátum:	2023
ISSN:	2045-2322
Megjegyzések:	Endocrine disorders negatively influence the ovarian function and increasing incidence of endocrine diseases with age may have further negative effects on pregnancy rate. Prospective cohort study of 231 consecutively enrolled patients underwent IVF treatment. In patients with known endocrine disorders the laboratory parameters were corrected before IVF treatment. 161 patients (69.7%) had at least one known and treated endocrine disorder (study group), and 70 patients were endocrine negative (control group). Endocrine disorders diagnosed were thyroid disorders (32,5%), diminished ovarian reserve (23,8%), insulin resistance (22,5%), PCOS (15,2%), hyperprolactinemia (13,4%), obesity (12,1%), hypogonadotropic hypogonadism (0,8%), congenital adrenal hyperplasia (0.2%). Before the IVF treatment systematic endocrine laboratory examinations were performed in all patients. Higher age, BMI, and FSH was found in the study group, while AMH level was lower. There were no differences in LH, E2, prolactin, TSH, FT3, FT4, TT, DHEAS, androstendione, 17-OHP, SHBG level between the study and control groups. The study group had higher baseline glucose, baseline insulin, 120 minute glucose and 120 minute insulin level after oral glucose tolerance test. With no difference in the IVF cycles performed, pregnancy rate was lower in the study group (61.43 % vs. 34.16 %; p=0.003), and this difference (p=0.0151) remained in age-corrected rates, as well. The analysis were also performed in individual endocrinology groups. The prevalence of endocrine disorders is high in females participating in IVF programs and they often accompanying to each other. Even after proper correction, the presence of the endocrine disorder negatively influences the pregnancy rate in IVF treatment.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk assisted reproduction in vitro fertilization endocrine diseases thyroid diseases
Megjelenés:	Reproductive Sciences. - 30 : 6 (2023), p. 1878-1890. -
További szerzők:	Csehely Szilvia (1990-) (szülész-nőgyógyász szakorvos) Orosz Mónika (1991-) (Szülész-nőgyógyász) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Deli Tamás Török Péter (1975-) (szülész-nőgyógyász) Laganà, Antonio Simone Chiantera, Vito Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM109152
035-os BibID:	(WoS)000937906300001 (Scopus)85148576802
Első szerző:	Török Péter (szülész-nőgyógyász)
Cím:	Reproductive outcomes after expectant and surgical management for tubal pregnancy : a retrospective study / Török Péter, Naem Antoine, Csehely Szilvia, Chiantera Vito, Sleiman Zaki, Lagana Antonio Simone
Dátum:	2023
ISSN:	1364-5706 1365-2931
Megjegyzések:	Background: The management of ectopic pregnancy is widely debated. Salpingectomy, salpin- gostomy, and expectant management are widely performed, but the best approach in terms of keeping good future spontaneous fertility chances is yet to be determined. Material and methods: We performed a retrospective analysis (Clinical Trial ID: NCT05479786) of the medical records of patients with an ultrasonographic or surgical diagnosis of tubal ectopic pregnancy that were admitted to the University of Debrecen Clinical Centre between 2012 and 2020. Results: A total of 312 patients were included in the analysis. Patients managed expectantly and patients treated with salpingostomy had significantly higher rates of clinical pregnancy than patients treated with salpingectomy. Pregnancy outcomes and recurrence rates were compar- able between the study groups. Salpingectomy was found to decrease the likelihood of conceiv- ing spontaneously by 65%. A stratified analysis based on serum b-HCG levels demonstrated that all treatment modalities carry the same reproductive opportunities for patients presenting with b-HCG levels 1745 IU/L. Conclusion: Salpingectomy was found to decrease the patient's chance of achieving a natural conception. Conservative approaches should be considered with caution only when the patient's clinical condition permits, and the patient is appropriately counseled.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Ectopic pregnancy expectant management pregnancy outcomes salpingectomy salpingostomy
Megjelenés:	Minimally Invasive Therapy & Allied Technologies. - 32 : 3 (2023), p. 127-135. -
További szerzők:	Naem, Antoine Csehely Szilvia (1990-) (szülész-nőgyógyász szakorvos) Chiantera, Vito Sleiman, Zaki Laganà, Antonio Simone
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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