CCL

Összesen 5 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM087704
035-os BibID:(cikkazonosító)1484 (WOS)000570425700001 (Scopus)85090955102
Első szerző:Kedves András
Cím:Predictive Value of Diffusion, Glucose Metabolism Parameters of PET/MR in Patients With Head and Neck Squamous Cell Carcinoma Treated With Chemoradiotherapy / Kedves András, Tóth Zoltán, Emri Miklós, Fábián Krisztián, Sipos Dávid, Freihat Omar, Tollár József, Cselik Zsolt, Lakosi Ferenc, Bajzik Gábor, Repa Imre, Kovács Árpád
Dátum:2020
ISSN:2234-943X
Megjegyzések:Purpose: This study aims to evaluate the predictive value of the pretreatment, metabolic, and diffusion parameters of a primary tumor assessed with PET/MR on patient clinical outcomes. Methods: Retrospective evaluation was performed using PET/MR image data sets acquired using the single tracer injection dual imaging of 68 histologically proven head and neck cancer patients 4 weeks before receiving definitive chemoradiotherapy (CRT). PET/MR was performed before the CRT and 12 weeks after the CRT for response evaluation. Image data (PET and MRI diffusion-weighted imaging [DWI]) was used to specify the maximum standard uptake value, the peak lean body mass corrected, SUVmax, the metabolic tumor volume, the total lesion glycolysis (SUVmax, SULpeak, MTV, and TLG), and the mean apparent diffusion coefficient (ADCmean) of the primary tumor. Based on the results of the therapeutic response evaluation, two patient subgroups were created: one with a viable tumor and another without. Metabolic and diffusion data, from the pretreatment PET/MR and the therapeutic response, were correlated using Spearman's correlation coefficient and Wilcoxon's test. Results: After completing the CRT, a viable residual tumor was detected in 36/68 (53%) cases, and 32/68 (47%) patients showed complete remission. However, no significant correlation was found between the pretreatment parameter, ADCmean (p = 0.88), and the therapeutic success. The PET parameters, SUVmax and SULpeak, MTV, and TLG (p = 0.032, p = 0.01, p < 0.0001, p = 0.0004) were statistically significantly different between the two patient subgroups. Kedves et al. Predictive Value of 18F-FDG PET/MR Conclusion: This study found that MRI-based (ADCmean) data from FDG PET/MR pretreatment could not be used to predict therapeutic response although the PET parameters SUVmax, SULpeak, MTV, and TLG proved to be more useful; thus, their inclusion in risk stratification may also be of additional value.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
PET/MR
predictive value
SUV
MTV
TLG
ADC
clinical outcome
squamous cell carcinoma
Megjelenés:Frontiers in Oncology. - 10 (2020), p. 1-11. -
További szerzők:Tóth Zoltán Emri Miklós (1962-) (fizikus) Fábián Krisztián Sipos Dávid Freihat, Omar Tollár József Cselik Zsolt Lakosi Ferenc Bajzik Gábor (1968-) (orvos) Repa Imre (1950-) (radiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM116763
035-os BibID:(cikkazonosító)1306329 (WoS)001124497600001 (Scopus)85179355665
Első szerző:Kovács Árpád (onkoradiológus, klinikai onkológus)
Cím:Editorial : LINAC-based stereotactic radiosurgery in daily practice / Kovács, Árpád; Lakosi, Ferenc
Dátum:2023
ISSN:2234-943X
Tárgyszavak:Orvostudományok Klinikai orvostudományok szerkesztői levél
folyóiratcikk
LINAC
SBRT
daily
SRT
practice
Megjelenés:Frontiers in Oncology. - 13 (2023), p. 1-3. -
További szerzők:Lakosi Ferenc
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM099845
035-os BibID:(cikkazonosító)745140 (WOS)000749873700001 (Scopus)85124040366
Első szerző:Papp Judit (onkoradiológus)
Cím:CBCT Verification of SRT for Patients With Brain Metastases / Papp Judit, Simon Mihály, Csiki Emese, Kovács Árpád
Dátum:2022
ISSN:2234-943X
Megjegyzések:Background: The aim of our work is to demonstrate the role of image guidance and volumetric imaging in stereotactic radiotherapy (SRT) of brain metastases. Methods: Between 2018 and 2020, 106 patients underwent intracranial stereotactic radiotherapy. 10 patients with metastatic brain tumors treated with SRT were randomly selected and included in our study model. Patients were scanned pre- and post-treatment with cone beam CT. Total of 100 verifications of 50 stereotaxic treatments were performed and analyzed. Results: Population mean X, Y, Z values were -0.13 cm, -0.04 cm, -0.03 cm, respectively, rotation values 0.81 degrees, 0.51 degrees, 0.46 degrees, respectively. Systematic error components for translational displacements pre corrections were as follows: 0.14 cm for X, 0.13 cm for Y and 0.1 cm for Z. Systematic error components of the post-treatment HR 3D CBCTs were as follows: 0.01 cm for X, 0.06 cm for Y and 0.04 cm for Z. Conclusions: Population mean values close to 0 confirmed that there is no systematic variation in our system and the accuracy of our equipment and tools is reliable. HR 3D CBCT scans performed pre SRTs further refine patient and target volume setting, support medical decision making and eliminate the possibility of gross error.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Oncology. - 11 (2022), p. 1-9. -
További szerzők:Simon Mihály (1981-) (Fizikus) Csiki Emese (1986-) (onkoradiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM100801
035-os BibID:(cikkazonosító)846609 (WOS)000776793600001 (Scopus)85127310676
Első szerző:Simon Mihály (Fizikus)
Cím:Plan Quality Assessment of Fractionated Stereotactic Radiotherapy Treatment Plans in Patients With Brain Metastases / Simon Mihály, Papp Judit, Csiki Emese, Kovács Árpád
Dátum:2022
ISSN:2234-943X
Megjegyzések:Background and Purpose: The treatment options available in the management of brain metastases includes fractionated stereotactic radiotherapy (FSRT) and stereotactic radiosurgery (SRS) treatments. FSRT treatments have proved to be useful mainly in the treatment of larger volumes. This study aims to evaluate the FSRT treatment technique used in our department based on various plan quality indices. Methods and Materials: 24 treatment plans of 23 patients were analyzed. Volumetric modulated arc therapy (VMAT) plans were generated in line with the department protocol. The following parameters were extracted: Radiation Therapy Oncology Group conformity index (RTOG CI), Paddick conformity index (Paddick CI), gradient index (GI), quality index (Q), homogeneity index (HI), and V24.4 volume as a parallel index of V12 used at SRS plan evaluation. Results: Plan conformity was acceptable, RTOG CI mean was 0.942; Paddick CI mean was 0.824. The mean GI value was 6.146. The mean of HI and Q indices were 1.263 and 0.94, respectively. V24.4 mean was 33.434 cm3 . All plans achieved clinically acceptable organs-at-risk (OAR) constraints. PTV volumes were clustered into either 10 cm3 or 15 cm3 bins depending on the plan quality metric we used. The mean values show a balanced distribution of plan indices along the various PTV bins. Discussion: Our results based on the derived indices show that our FSRT approach can achieve clinically acceptable treatment plans. Furthermore, the clustering of PTV volumes show that these plan quality metrics remain acceptable for a wide spectrum of PTV volumes. Keywords: FSRT = fractionated stereotactic radiotherapy, brain metastases, conformity index (CI), lina
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Oncology. - 12 (2022), p. 1-8. -
További szerzők:Papp Judit (1971-) (onkoradiológus) Csiki Emese (1986-) (onkoradiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM095649
035-os BibID:(cikkazonosító)699360 (WOS)000674593900001 (Scopus)85111019879
Első szerző:Sipos Dávid
Cím:Additional Value of 18F-FDOPA Amino Acid Analog Radiotracer to Irradiation Planning Process of Patients With Glioblastoma Multiforme / David Sipos, Zoltan László, Zoltan Tóth, Peter Kovács, Jozsef Tollár, Akos Gulybán, Ferenc Lakosi, Imre Repa, Arpad Kovács
Dátum:2021
ISSN:2234-943X
Megjegyzések:Purpose To investigate the added value of 6-(18F]-fluoro-L-3,4-dihydroxyphenylalanine (FDOPA) PET to radiotherapy planning in glioblastoma multiforme (GBM). Methods From September 2017 to December 2020, 17 patients with GBM received external beam radiotherapy up to 60 Gy with concurrent and adjuvant temozolamide. Target volume delineations followed the European guideline with a 2-cm safety margin clinical target volume (CTV) around the contrast-enhanced lesion+resection cavity on MRI gross tumor volume (GTV). All patients had FDOPA hybrid PET/MRI followed by PET/CT before radiotherapy planning. PET segmentation followed international recommendation: T/N 1.7 (BTV1.7) and T/N 2 (BTV2.0) SUV thresholds were used for biological target volume (BTV) delineation. For GTV-BTVs agreements, 95% of the Hausdorff distance (HD95%) from GTV to the BTVs were calculated, additionally, BTV portions outside of the GTV and coverage by the 95% isodose contours were also determined. In case of recurrence, the latest MR images were co-registered to planning CT to evaluate its location relative to BTVs and 95% isodose contours. Results Average (range) GTV, BTV1.7, and BTV2.0 were 46.58 (6-182.5), 68.68 (9.6-204.1), 42.89 (3.8-147.6) cm(3), respectively. HD95% from GTV were 15.5 mm (7.9-30.7 mm) and 10.5 mm (4.3-21.4 mm) for BTV1.7 and BTV2.0, respectively. Based on volumetric assessment, 58.8% (28-100%) of BTV1.7 and 45.7% of BTV2.0 (14-100%) were outside of the standard GTV, still all BTVs were encompassed by the 95% dose. All recurrences were confirmed by follow-up imaging, all occurred within PTV, with an additional outfield recurrence in a single case, which was not DOPA-positive at the beginning of treatment. Good correlation was found between the mean and median values of PET/CT and PET/MRI segmented volumes relative to corresponding brain-accumulated enhancement (r = 0.75; r = 0.72). Conclusion (18F)FDOPA PET resulted in substantial larger tumor volumes compared to MRI; however, its added value is unclear as vast majority of recurrences occurred within the prescribed dose level. Use of PET/CT signals proved to be feasible in the absence of direct segmentation possibilities of PET/MR in TPS. The added value of (18F)FDOPA may be better exploited in the context of integrated dose escalation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Oncology. - 11 (2021), p. 1-11. -
További szerzők:László Zoltán (1979-) (biokémikus, molekuláris biológus) Tóth Zoltán Kovács Péter Tollár József Gulybán Ákos (Pécs) Lakosi Ferenc Repa Imre (1950-) (radiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1 
Corvina könyvtári katalógus v8.2.27 © 2023 Monguz kft. Minden jog fenntartva.