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001-es BibID:	BIBFORM065768
Első szerző:	Lakosi Ferenc
Cím:	Respiratory Motion, Anterior Heart Displacement and Heart Dosimetry : Comparison Between Prone (Pr) and Supine (Su) Whole Breast Irradiation / Ferenc Lakosi, Akos Gulyban, Levente Janvary, Selma Ben-Mustapha Simoni, Nicolas Jansen, Laurence Seidel, Arpad Kovacs, Peter Vavassis, Philippe Coucke,
Dátum:	2015
ISSN:	1219-4956 1532-2807
Megjegyzések:	Abstract: To analyze respiratory motion of surgical clips,chest wall (CW) and the anterior displacement of the heartand its impact on heart dosimetry between prone (Pr) andsupine (Su) positions during whole breast radiotherapy afterbreast conserving surgery. Sixteen patients underwent 4D-CTfor radiotherapy planning in Pr and Su positions. Maximuminhale and maximum exhale phases were analyzed. Mean 3Dvectorial displacements?standard deviations (SD) of the surgical clips were measured. Volumetric changes of the CWwere recorded and compared. Cardiac displacement wasassessed by a volume between the inner surface of CW andthe myocardium of the heart (CW/H-V). For left-sided cases,comparative dosimetry was performed in each position simulating no- (Pr-noC, Su-noC) versus daily correction protocols (Pr-C, Su-C). The movements of 81 surgical clips were analyzed. Prone positioning significantly reduced both the mean 3D vectorial displacements (1.1?0.6 (Pr) vs. 2.0?0.9 mm (Su), p<0.01) and their variability (0.3?0.2 vs. 0.5?0.3 mm,p=0.01). Respiration-induced volumetric changes of CW were also significantly lower in Pr (2.3?4.9 vs. 9.6?7.1 cm3 , p<0.01). The CW/H-V was significantly smaller inPr than in Su (39.9?14.6 vs. 64.3?28.2 cm3 , p<0.01). Besides identical target coverage heart, left-anterior-descending coronary artery (LADCA) and ipsilateral lung dose parameters were lowered with Pr-C compared to Pr-noC, Su-C and Su-noC. Prone position significantly reduced respiration related surgical clip movements, their variability as well as CW movements. Significant anterior heart displacement wasobserved in Pr. Prone position with daily online correctioncould maximize the heart and LADCA protection.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban Breast cancer Prone breast radiotherapy 4D-computed tomography Respiratory motion Left-anterior-descending coronary artery
Megjelenés:	Pathology & Oncology Research 21 : 4 (2015), p. 1051-1058. -
További szerzők:	Gulybán Ákos (Pécs) Jánváry Zsolt Levente (1977-) (orvos) Simoni, Selma Ben-Mustapha Jansen, Nicolas Seidel, Laurence Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus) Vavassis, Peter Coucke, Philippe A.
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001-es BibID:	BIBFORM095649
035-os BibID:	(cikkazonosító)699360 (WOS)000674593900001 (Scopus)85111019879
Első szerző:	Sipos Dávid
Cím:	Additional Value of 18F-FDOPA Amino Acid Analog Radiotracer to Irradiation Planning Process of Patients With Glioblastoma Multiforme / David Sipos, Zoltan László, Zoltan Tóth, Peter Kovács, Jozsef Tollár, Akos Gulybán, Ferenc Lakosi, Imre Repa, Arpad Kovács
Dátum:	2021
ISSN:	2234-943X
Megjegyzések:	Purpose To investigate the added value of 6-(18F]-fluoro-L-3,4-dihydroxyphenylalanine (FDOPA) PET to radiotherapy planning in glioblastoma multiforme (GBM). Methods From September 2017 to December 2020, 17 patients with GBM received external beam radiotherapy up to 60 Gy with concurrent and adjuvant temozolamide. Target volume delineations followed the European guideline with a 2-cm safety margin clinical target volume (CTV) around the contrast-enhanced lesion+resection cavity on MRI gross tumor volume (GTV). All patients had FDOPA hybrid PET/MRI followed by PET/CT before radiotherapy planning. PET segmentation followed international recommendation: T/N 1.7 (BTV1.7) and T/N 2 (BTV2.0) SUV thresholds were used for biological target volume (BTV) delineation. For GTV-BTVs agreements, 95% of the Hausdorff distance (HD95%) from GTV to the BTVs were calculated, additionally, BTV portions outside of the GTV and coverage by the 95% isodose contours were also determined. In case of recurrence, the latest MR images were co-registered to planning CT to evaluate its location relative to BTVs and 95% isodose contours. Results Average (range) GTV, BTV1.7, and BTV2.0 were 46.58 (6-182.5), 68.68 (9.6-204.1), 42.89 (3.8-147.6) cm(3), respectively. HD95% from GTV were 15.5 mm (7.9-30.7 mm) and 10.5 mm (4.3-21.4 mm) for BTV1.7 and BTV2.0, respectively. Based on volumetric assessment, 58.8% (28-100%) of BTV1.7 and 45.7% of BTV2.0 (14-100%) were outside of the standard GTV, still all BTVs were encompassed by the 95% dose. All recurrences were confirmed by follow-up imaging, all occurred within PTV, with an additional outfield recurrence in a single case, which was not DOPA-positive at the beginning of treatment. Good correlation was found between the mean and median values of PET/CT and PET/MRI segmented volumes relative to corresponding brain-accumulated enhancement (r = 0.75; r = 0.72). Conclusion (18F)FDOPA PET resulted in substantial larger tumor volumes compared to MRI; however, its added value is unclear as vast majority of recurrences occurred within the prescribed dose level. Use of PET/CT signals proved to be feasible in the absence of direct segmentation possibilities of PET/MR in TPS. The added value of (18F)FDOPA may be better exploited in the context of integrated dose escalation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Oncology. - 11 (2021), p. 1-11. -
További szerzők:	László Zoltán (1979-) (biokémikus, molekuláris biológus) Tóth Zoltán Kovács Péter Tollár József Gulybán Ákos (Pécs) Lakosi Ferenc Repa Imre (1950-) (radiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
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