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1.

001-es BibID:BIBFORM090005
Első szerző:Cselik Zsolt
Cím:Predictive value of PET/CT based metabolic information in the modern 3D based radiotherapy treatment of head and neck can-cer patients - single institute study / Zsolt Cselik, Zoltán Tóth, András Kedves, Dávid Sipos, Omar Freihat, Tímea Vecsera, Gábor Lukács, Miklós Emri, Gábor Bajzik, Janaki Hadjiev, Imre Repa, Mariann Moizs, Árpád Kovács
Dátum:2020
Megjegyzések:Objective: The aim of the study was to evaluate the predictive value of pretreatment positron emission tomography (PET) standardized uptake value (SUVmax), standardized uptake value corrected for lean body mass (SULpeak) value, metabolic tumour volume (MTV) and total lesion glycolysis (TLG) parameters of the primary tumour assessed with PET/computed tomography (CT) in the clinical out-come in patients diagnosed with histopathologically confirmed head and neck squamous cell carcinoma. Materials and methods: Retrospective evaluation was performed using PET/CT image datasets of 52 histologically proven head and neck cancer patients in 4 weeks' prior receiving definitive chemo-radiotherapy (CRT). Positron emission tomography /CT was performed before the CRT and 12 weeks after it for response evaluation. Image data was used for target volume delineation and for specify SUVmax, SULpeak, MTV and TLG parameters of the primary tumour. According to the results of the therapeutic response evaluation two patient subgroups were created in relation to the presence or absence of viable tumour. Metabolic data from pre-treatment PET/CT and therapeutic response were correlated using Kruskal-Wallis test. Results: After completion of the CRT in 24/52 (46%) cases viable residual tumour was detected on restaging PET/CT, while in 28/52 (54%) patients showed complete remission. For the therapeutic success prediction assessment, we could not find any significant correlation with pre-treatment SUVmax and SULpeak values (P>0.44, P>0.33). Total lesion glycolysis provided nearly significant difference (P=0.052) and MTV had shown significant difference (P=0.001) between the two patient subgroups statistically. Conclusion: Simple metabolic data (SUVmax and SULpeak) from pretreatment fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT were unable to predict therapeutic response, while volumetric information containing MTV and TLG parameters proved to be more useful, thus their inclusion to risk stratification may also have additional value.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Hellenic Journal of Nuclear Medicine. - 23 : 3 (2020), p. 165-171. -
További szerzők:Tóth Zoltán Kedves András Sipos Dávid Freihat, Omar Vecsera Tímea Lukács Gábor Emri Miklós (1962-) (fizikus) Bajzik Gábor (1968-) (orvos) Hadjiev, Janaki Repa Imre (1950-) (radiológus) Moizs Marianna (1964-) (orvos) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
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2.

001-es BibID:BIBFORM100238
035-os BibID:(cikkazonosító)847 (WoS)000755032500001 (Scopus)85124104299
Első szerző:Freihat, Omar
Cím:Correlation between Tissue Cellularity and Metabolism Represented by Diffusion-Weighted Imaging (DWI) and 18F-FDG PET/MRI in Head and Neck Cancer (HNC) / Freihat Omar, Zoltán Tóth, Pinter Tamas, Kedves András, Sipos Dávid, Repa Imre, Kovács Árpád, Zsolt Cselik
Dátum:2022
ISSN:2072-6694
Megjegyzések:Background: This study aimed to assess the association of 18F-Fluorodeoxyglucose positronemission-tomography (18F-FDG/PET) and DWI imaging parameters from a primary tumor and their correlations with clinicopathological factors. Methods: We retrospectively analyzed primary tumors in 71 patients with proven HNC. Primary tumor radiological parameters: DWI and FDG, as well as pathological characteristics were analyzed. Spearman correlation coefficient was used to assess the correlation between DWI and FDG parameters, ANOVA or Kruskal?Wallis, independent sample t-test, Mann?Whitney test, and multiple regression were performed on the clinicopathological features that may affect the 18F- FDG and apparent-diffusion coefficient (ADC) of the tumor. Results: No significant correlations were observed between DWI and any of the 18F-FDG parameters (p > 0.05). SUVmax correlated with N-stages (p = 0.023), TLG and MTV correlated with T-stages (p = 0.006 and p = 0.001), and ADC correlated with tumor grades (p = 0.05). SUVmax was able to differentiate between N+ and N? groups (p = 0.004). Conclusions: Our results revealed a non-significant correlation between the FDG-PET and ADC-MR parameters. FDG-PET-based glucose metabolic and DWI-MR-derived cellularity data may represent different biological aspects of HNC
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Cancers. - 14 : 3 (2022), p. 1-12. -
További szerzők:Tóth Zoltán Pintér Tamás Kedves András Sipos Dávid Repa Imre (1950-) (radiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus) Cselik Zsolt
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM091918
035-os BibID:(cikkazonosító)105239 (WoS)000661128300005 (Scopus)85101311820
Első szerző:Freihat, Omar
Cím:Pre-treatment PET/MRI based FDG and DWI imaging parameters for predicting HPV status and tumor response to chemoradiotherapy in primary oropharyngeal squamous cell carcinoma (OPSCC) / Freihat Omar, Tóth Zoltán, Pintér Tamás, Kedves András, Sipos Dávid, Cselik Zsolt, Lippai Norbert, Repa Imre, Kovács Árpád
Dátum:2021
ISSN:1368-8375
Megjegyzések:Objectives: To determine the feasibility of pre-treatment primary tumor FDG-PET and DWI-MR imaging param-eters in predicting HPV status and the second aim was to assess the feasibility of those imaging parameters to predict response to therapy. Material and Methods: We retrospectively analyzed primary tumors in 33 patients with proven OPSCC. PET/MRI was performed before and 6 months after chemo-radiotherapy for assessing treatment response. PET Stan-dardized uptake value (SUVmax), total lesion glycolysis (TLG), metabolic tumor volume (MTV), and apparent diffusion coefficient (ADC) from pre-treatment measurements were assessed and compared to the clinicopath-ological characteristics (T stages, N stages, tumor grades, HPV and post-treatment follow up). HPV was corre-lated to the clinicopathological characteristics. Results: ADCmean was significantly lower in patients with HPV+ve than HPV-ev, (P =0.001), cut off value of (800 ?0.44*10-3mm2/s) with 76.9% sensitivity, and 72.2% specificity is able to differentiate between the two groups. No significant differences were found between FDG parameters (SUVmax, TLG, and MTV), and HPV status, (P =0.873, P =0.958, and P =0.817), respectively. Comparison between CR and NCR groups; ADCmean, TLG, and MTV were predictive parameters of treatment response, (P =0.017, P =0.013, and P =0.014), respectively. HPV+ve group shows a higher probability of lymph nodes involvement, (P =0.006) Conclusion: Our study found that pretreatment ADC of the primary tumor can predict HPV status and treatment response. On the other hand, metabolic PET parameters (TLG, and MTV) were able to predict primary tumor response to therapy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Oral Oncology. - 116 (2021), p. 1-8. -
További szerzők:Tóth Zoltán Pintér Tamás Kedves András Sipos Dávid Cselik Zsolt Lippai Norbert Repa Imre (1950-) (radiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM087402
Első szerző:Freihat, Omar
Cím:Diffusion-Weighted Imaging (DWI) derived from PET/MRI for lymph node assessment in patients with Head and Neck Squamous Cell Carcinoma (HNSCC) / Omar Freihat, Tamas Pinter, András Kedves, Dávid Sipos, Zsolt Cselik, Imre Repa, Árpád Kovács
Dátum:2020
ISSN:1740-5025 1470-7330
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
MRI
DWI
ADC
HNSCC
Metastasis
Benign
Lymph nodes
Megjelenés:Cancer Imaging. - 20 : 56 (2020), p. 1-12. -
További szerzők:Pintér Tamás Kedves András Sipos Dávid Cselik Zsolt Repa Imre (1950-) (radiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM087704
035-os BibID:(cikkazonosító)1484 (WOS)000570425700001 (Scopus)85090955102
Első szerző:Kedves András
Cím:Predictive Value of Diffusion, Glucose Metabolism Parameters of PET/MR in Patients With Head and Neck Squamous Cell Carcinoma Treated With Chemoradiotherapy / Kedves András, Tóth Zoltán, Emri Miklós, Fábián Krisztián, Sipos Dávid, Freihat Omar, Tollár József, Cselik Zsolt, Lakosi Ferenc, Bajzik Gábor, Repa Imre, Kovács Árpád
Dátum:2020
ISSN:2234-943X
Megjegyzések:Purpose: This study aims to evaluate the predictive value of the pretreatment, metabolic, and diffusion parameters of a primary tumor assessed with PET/MR on patient clinical outcomes. Methods: Retrospective evaluation was performed using PET/MR image data sets acquired using the single tracer injection dual imaging of 68 histologically proven head and neck cancer patients 4 weeks before receiving definitive chemoradiotherapy (CRT). PET/MR was performed before the CRT and 12 weeks after the CRT for response evaluation. Image data (PET and MRI diffusion-weighted imaging [DWI]) was used to specify the maximum standard uptake value, the peak lean body mass corrected, SUVmax, the metabolic tumor volume, the total lesion glycolysis (SUVmax, SULpeak, MTV, and TLG), and the mean apparent diffusion coefficient (ADCmean) of the primary tumor. Based on the results of the therapeutic response evaluation, two patient subgroups were created: one with a viable tumor and another without. Metabolic and diffusion data, from the pretreatment PET/MR and the therapeutic response, were correlated using Spearman's correlation coefficient and Wilcoxon's test. Results: After completing the CRT, a viable residual tumor was detected in 36/68 (53%) cases, and 32/68 (47%) patients showed complete remission. However, no significant correlation was found between the pretreatment parameter, ADCmean (p = 0.88), and the therapeutic success. The PET parameters, SUVmax and SULpeak, MTV, and TLG (p = 0.032, p = 0.01, p < 0.0001, p = 0.0004) were statistically significantly different between the two patient subgroups. Kedves et al. Predictive Value of 18F-FDG PET/MR Conclusion: This study found that MRI-based (ADCmean) data from FDG PET/MR pretreatment could not be used to predict therapeutic response although the PET parameters SUVmax, SULpeak, MTV, and TLG proved to be more useful; thus, their inclusion in risk stratification may also be of additional value.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
PET/MR
predictive value
SUV
MTV
TLG
ADC
clinical outcome
squamous cell carcinoma
Megjelenés:Frontiers in Oncology. - 10 (2020), p. 1-11. -
További szerzők:Tóth Zoltán Emri Miklós (1962-) (fizikus) Fábián Krisztián Sipos Dávid Freihat, Omar Tollár József Cselik Zsolt Lakosi Ferenc Bajzik Gábor (1968-) (orvos) Repa Imre (1950-) (radiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM116530
035-os BibID:(WoS)001142439600001 (scopus)85177696261
Első szerző:Sipos Dávid
Cím:Reduced burnout in medical and health science students during the pandemic COVID-19 : a follow-up study of a single institution in Hungary / Sipos David, Biro Anett Anna, Busa Flora, Freihat Omar, Tollár József, Pandur Attila András, Kovács Árpád, Deutsch Krisztina, Csima Melinda Petőné
Dátum:2023
ISSN:1472-6920
Megjegyzések:Background The coronavirus pandemic has significantly impacted lives worldwide, especially of medical and health science students. In Hungary, education has been relegated to the online space, with a substantial proportion of students having to attend medical secondments. Increased stress, uncertainty, and the presence of medical secondments can have an impact on students' premature burnout. Methods In 2021, we conducted a follow-up survey among students of the University of Pécs studying medicine and health sciences in two data collection periods (from March to May and September to November). Our online questionnaire consisted of the Maslach Burnout Inventory General Survey for Students and our self-designed questionnaire. We used descriptive and paired two-sample t-tests for data analysis at a 95% confidence interval (p <= 0.05). Results We excluded from our survey respondents whose data we could not follow-up; finally, 183 students' responses were analyzed. The majority of students were female (n=148; 80.9%). Overall, there was a significant decrease in both exhaustion (EX) and cynicism (CY) scores (p=0.001; p=0.004). Female respondents had higher EX scores, but a significant decrease was observed for both genders (p?0.05). Excluding paramedic students, a significant decrease in EX scores was observed for the specialties we studied (p <= 0.05). General medicine students' CY scores decreased; physiotherapy students' profesisonal efficacy (PE) scores increased significantly (p <= 0.05). Students who were on medical secondments (n=127; 69. 4%) were found to be more affected by burnout, but in all cases, these scores significantly improved (p <= 0.05). Students serving in the National Ambulance Service (n=76; 41.5%), Hospitals (n=44; 24.0%), or both (n=7; 3.8%) had a significant decrease in their burnout score (p <= 0.05). Students who served in either a hospital or a hospital and National Ambulance Service had significantly improved CY and PE scores (p <= 0.05). Students concerned about their health had elevated EX and CY scores, which also improved (p <= 0.05).
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Student
Burnout
COVID-19
Secondment
Maslach burnout inventory general survey for students scale
Megjelenés:BMC Medical Education. - 23 : 1 (2023), p. 1-8. -
További szerzők:Biró Anett Anna Busa Flóra Freihat, Omar Tollár József Pandur Attila András Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus) Deutsch Krisztina Petőné Csima Melinda
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Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM108912
035-os BibID:(Scopus)85149300395 (WoS)000953322600001
Első szerző:Sipos Dávid
Cím:Burnout and occupational stress among Hungarian radiographers working in emergency and non-emergency departments during COVID-19 pandemic / Sipos David, Jenei Timea, Kövesdi Orsolya Liza, Novák Pál, Freihat Omar, Tollár József, Pandur Attila András, Kovács Árpád, Repa Imre, Petőné Csima Melinda
Dátum:2023
ISSN:1078-8174 1532-2831
Megjegyzések:Introduction The increased workload caused by the coronavirus pandemic may have had a significant impact on the mental health of radiographers. The aim of our study was to investigate burnout and occupational stress in radiographers working in emergency departments (ED) and non-emergency departments (NED) Methods Quantitative, cross-sectional, descriptive research was carried out among radiographers working in the public health sector in Hungary. Due to the cross-sectional nature of our survey, there was no overlap between the ED and NED groups. For data collection, we used simultaneously the Maslach Burnout Inventory (MBI), the Effort-Reward Imbalance questionnaire (ERI), and our self-designed questionnaire Results We excluded incomplete questionnaires from our survey; finally, 439 responses were evaluated. Significantly higher scores for depersonalisation (DP; 8.43 (SD=6.69) vs. 5.63 (SD=4.21) and emotional exhaustion (EE; 25.07 (SD=11.41) vs. 19.72 (SD=11.72)) were observed in radiographers working in ED (p=0.001; p=0.001) when compared to NED. Male radiographers working in ED aged 20-29 and 30-39 years with experience of 1-9 years were more affected by DP (p?0.05). Worrying about one's own health had a negative effect on DP and EE (p?0.05). Having close friend with a COVID-19 infection had a negative effect on EE (p?0.05); not being infected with coronavirus, not being quarantined and relocating within the workplace had a positive effect on personal accomplishment (PA); radiographers who were 50 years or older with 20-29 years of experience were more affected by depersonalisation (DP); and those who worried about their health had significantly higher stress scores (p?0.05) in both ED and NED settings Conclusion Male radiographers at the beginning of their careers were more affected by burnout. Employment in EDs had a negative impact on DP and EE
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
radiographer
coronavirus
MBI
ERI
emergency
mental health
burnout
stress
Megjelenés:Radiography. - 29 : 3 (2023), p. 466-472. -
További szerzők:Jenei Timea Kövesdi Orsolya Liza Novák Pál Freihat, Omar Tollár József Pandur Attila András Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus) Repa Imre (1950-) (radiológus) Petőné Csima Melinda
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Intézményi repozitóriumban (DEA) tárolt változat
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8.

001-es BibID:BIBFORM088768
Első szerző:Sipos Dávid
Cím:Possible predictors of burnout among radiographers in Hungary : demographic and work related characteristics / David Sipos, Omar Freihat, Attila András Pandur, József Tollár, András Kedves, Imre Repa, Árpád Kovács, Melinda Petőné Csima
Dátum:2020
ISSN:1212-4117 1804-7122
Megjegyzések:Introduction: The risk of burnout in healthcare can affect the quality of patient care. The purpose of this study was to assess burnout rates among Hungarian radiographers to find out the possible reasons behind the phenomenon. Methods: Quantitative, cross-sectional, descriptive data collection was conducted from June to September 2018. In addition to socio-demographic and work-related characteristics, an internationally validated Maslach Burnout Inventory (MBI) was used. Descriptive statistics, one-sample t-test, ANOVA, Mann-Whitney and Kruskal-Wallis test with 95% probability were used for statistical items (p = 0.05). Results: We examined 238 radiographers' data with the mean age of 34.42 years (SD 10.53). Woman respondents dominated the sample but male respondents tend to be more affected by burnout (p = 0.001). Working over 50 hours per week affected negatively the dimensions of depersonalization and emotional exhaustion. 40 to 50 hours of work per week affected foremost the personal achievement dimension (p = 0.001). Radiographers working in oncology patient care are more affected by emotional exhaustion (p = 0.001). Respondents who rated their health as excellent had higher values of personal achievement (p = 0.01). They also had significantly lower levels of emotional exhaustion than respondents who considered their health status to be tolerable or poor (p = 0.001). Conclusions: The extent of burnout may vary depending on the radiographers' work related characteristics. Understanding the risk factors associated with burnout may help us develop strategies for prevention.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Burnout
Healthcare
Maslach Burnout Inventory
Radiographer
Megjelenés:Kontakt. - 22 : 4 (2020), p. 228-234. -
További szerzők:Freihat, Omar Pandur Attila András Tollár József Kedves András Repa Imre (1950-) (radiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus) Petőné Csima Melinda
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Intézményi repozitóriumban (DEA) tárolt változat
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