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001-es BibID:	BIBFORM118614
035-os BibID:	(cikkazonosító)1611589 (WoS)001152827800001 (Scopus)85186741412
Első szerző:	Kovács Árpád (onkoradiológus, klinikai onkológus)
Cím:	LINAC-based SBRT in treating early-stage NSCLC patients : single institution experience and survival data analysis / Kovács Árpád, Trási Krisztina, Barabás Márton, Gál Kristóf, Csiki Emese, Sipos Dávid, Papp Judit, Simon Mihály
Dátum:	2024
ISSN:	1219-4956 1532-2807
Megjegyzések:	Aim: This single institute prospective study aimed to evaluate the feasibility of LINAC-based stereotactic body radiotherapy (SBRT) in treating patients with early-stage non-small cell lung cancer (NSLSC). We focused on the survival data with the local and distant control profiles and the cancer- and non-cancer-specific survival. Treatment-related side effects were also collected and analyzed.Methods: Patients with early-stage NSCLC between January 2018 and October 2021 were included in our prospective study; a total of 77 patients receiving LINAC-based SBRT were analyzed. All patients had pretreatment multidisciplinary tumor board decisions on SBRT. The average patient age was 68.8 years (median: 70 years, range: 52-82); 70 patients were in ECOG 0 status (91%), while seven patients were in ECOG 1-2 status (9%). 52% of the patients (40) had histologically verified NSCLC, and the other 48% were verified based on PETCT results. We applied the SBRT scheme 8 x 7.5 Gy for central tumors (74%) or 4 x 12 Gy for peripheral tumors (26%).Results: The mean follow-up time was 25.4 months (median 23, range 18-50). The Kaplan-Meier estimation for overall survival in patients receiving LINAC-based SBRT was 41.67 months. Of the 77 patients treated by SBRT, death was reported for 17 patients (9 cases cancer-specific, 8 cases non-cancer specific reason). The mean local tumor control was 34.25 months (range 8.4-41), and the mean systemic control was 24.24 months (range 7-25). During the treatments, no Grade I-II were reported; in 30 cases, Grade I non-symptomatic treatment-related lung fibrosis and two asymptomatic rib fractures were reported.Conclusion: In the treatment of early-stage NSCLC, LINAC-based SBRT can be a feasible alternative to surgery. Although we reported worse OS data in our patient cohort compared to the literature, the higher older average age and the initial worse general condition (ECOG1-2) in our patient cohort appear to be the reason for this difference. With the comparable local control and survival data and the favorable side effect profile, SBRT might be preferable over surgery in selected cases.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk VATS NSCLC SBRT LINAC-based SBRT early stage
Megjelenés:	Pathology & Oncology Research. - 30 (2024), p. 1-6. -
További szerzők:	Trási Krisztina Barabás Márton Gál Kristóf (1994-) (orvos) Csiki Emese (1986-) (onkoradiológus) Sipos Dávid Papp Judit (1971-) (onkoradiológus) Simon Mihály (1981-) (Fizikus)
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001-es BibID:	BIBFORM105987
Első szerző:	Kovács Árpád (onkoradiológus, klinikai onkológus)
Cím:	Korai stadiumú tüdő NSCLC betegek modern ellátása. A DE KK 5 éves korai eredményei klasszikus műtét és SBRT összevetésében / Kovács Árpád, Csiki Emese, Lieber Attila, Takács István, Bittner Nóra, Trási Krisztina, Papp Judit, Simon Mihály
Dátum:	2022
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Medicina Thoracalis. - 75 : 3 (2022), p. 167-168. -
További szerzők:	Csiki Emese (1986-) (onkoradiológus) Lieber Attila (1978-) Takács István (1963-) (sebész) Bittner Nóra (1963-) (orvos) Trási Krisztina Papp Judit (1971-) (onkoradiológus) Simon Mihály (1981-) (Fizikus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: