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001-es BibID:	BIBFORM119605
035-os BibID:	(Scopus)85186461125 (WoS)001174194600002
Első szerző:	Filipov, Teodóra
Cím:	Investigating the role of ultrasound-based shear wave elastography in kidney transplanted patients : correlation between non-invasive fibrosis detection, kidney dysfunction and biopsy results - a systematic review and meta-analysis / Teodóra Filipov, Brigitta Teutsch, Anett Szabó, Attila Forintos, Júlia Ács, Alex Váradi, Péter Hegyi, Tibor Szarvas, Nándor Ács, Péter Nyirády, Pál Ákos Deák
Dátum:	2024
ISSN:	1724-6059
Megjegyzések:	Introduction: Interstitial fibrosis and tubular atrophy are leading causes of renal allograft failure. Shear wave elastography could be a promising noninvasive method for providing information on the state of the kidney, with specific regard to fibrosis but currently available data in the literature are controversial. Our study aimed to analyze the correlation between shear wave elastography and various kidney dysfunction measures. Methods: This review was registered on PROSPERO (CRD42021283152). We systematically searched three major databases (MEDLINE, Embase, and CENTRAL) for articles concerning renal transplant recipients, shear wave elastography, fibrosis, and kidney dysfunction. Meta-analytical calculations for pooled Pearson and Spearman correlation coefficients (r) were interpreted with 95% confidence intervals (CIs). Heterogeneity was tested with Cochran's Q test. I2 statistic and 95% CI were reported as a measurement of between-study heterogeneity. Study quality was assessed with the QUADAS2 tool. Results: In total, 16 studies were included in our meta-analysis. Results showed a moderate correlation between kidney stiffness and interstitial fibrosis and tubular atrophy, graded according to BANFF classification, on biopsy findings for pooled Pearson (r = 0.48; CI: 0.20, 0.69; I2 = 84%) and Spearman correlations (r = 0.57; CI: 0.35, 0.72; I2 = 74%). When compared to kidney dysfunction parameters, we found a moderate correlation between shear wave elastography and resistive index (r = 0.34 CI: 0.13, 0.51; I2 = 67%) and between shear wave elastography and estimated Glomerular Filtration Rate (eGFR) (r = -0.65; CI: ? 0.81, ? 0.40; I2 = 73%). All our outcomes had marked heterogeneity. Conclusion: Our results showed a moderate correlation between kidney stiffness measured by shear wave elastography and biopsy results. While noninvasive assessment of kidney fibrosis after transplantation is an important clinical goal, there is insufficient evidence to support the use of elastography over the performance of a kidney biopsy. Graphical abstract: (Figure presented.)
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Sonoelastography Shear wave elastography Renal transplantation Biopsy
Megjelenés:	Journal of Nephrology. - [Epub ahead of print] (2024). -
További szerzők:	Teutsch Brigitta Szabó Anett (élettanász) Forintos Attila Ács Júlia Váradi Alex (1991-) (biológus) Hegyi Péter Szarvas Tibor (matematikus informatikus) Ács Nándor Nyirády Péter Deák Pál Ákos
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001-es BibID:	BIBFORM116419
035-os BibID:	(cikkazonosító)4224 (Scopus)85173813933 (WoS)001083061000001
Első szerző:	Greff Dorina
Cím:	Myoinositols Prevent Gestational Diabetes Mellitus and Related Complications : a Systematic Review and Meta-Analysis of Randomized Controlled Trials / Dorina Greff, Szilárd Váncsa, Alex Váradi, Julia Szinte, Sunjune Park, Péter Hegyi, Péter Nyirády, Nándor Ács, Eszter Mária Horváth, Szabolcs Várbíró
Dátum:	2023
ISSN:	2072-6643
Megjegyzések:	Although gestational diabetes mellitus (GDM) has several short- and long-term adverse effects on the mother and the offspring, no medicine is generally prescribed to prevent GDM. The present systematic review and meta-analysis aimed to investigate the effect of inositol supplementation in preventing GDM and related outcomes. Systematic search was performed in CENTRAL, MEDLINE, and Embase until 13 September 2023. Eligible randomized controlled trials (RCTs) compared the efficacy of inositols to placebo in pregnant women at high risk for GDM. Our primary outcome was the incidence of GDM, whereas secondary outcomes were oral glucose tolerance test (OGTT) and maternal and fetal complications. (PROSPERO registration number: CRD42021284939). Eight eligible RCTs were identified, including the data of 1795 patients. The incidence of GDM was halved by inositols compared to placebo (RR = 0.42, CI: 0.26?0.67). Fasting, 1-h, and 2-h OGTT glucose levels were significantly decreased by inositols. The stereoisomer myoinositol also reduced the risk of insulin need (RR = 0.29, CI: 0.13?0.68), preeclampsia or gestational hypertension (RR = 0.38, CI: 0.2?0.71), preterm birth (RR = 0.44, CI: 0.22?0.88), and neonatal hypoglycemia (RR = 0.12, CI: 0.03?0.55). Myoinositol decrease the incidence of GDM in pregnancies high-risk for GDM. Moreover, myoinositol supplementation reduces the risk of insulin need, preeclampsia or gestational hypertension, preterm birth, and neonatal hypoglycemia. Based on the present study 2?4 g myoinositol canbe suggested from the first trimester to prevent GDM and related outcomes.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk GDM inositol preterm birth neonatal maternal health gestational hypertension preeclampsia
Megjelenés:	Nutrients. - 15 : 19 (2023), p. 1-16. -
További szerzők:	Váncsa Szilárd Váradi Alex (1991-) (biológus) Szinte Julia Park, Sunjune Hegyi Péter Jenő (belgyógyász) Nyirády Péter Ács Nándor Horváth Eszter Mária Várbíró Szabolcs
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