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001-es BibID:	BIBFORM111659
035-os BibID:	(Scopus)85166916995
Első szerző:	Czapári Dóra
Cím:	Detailed characteristics of post-discharge mortality in acute pancreatitis / Dóra Czapári, Alex Váradi, Nelli Farkas, Gergely Nyári, Katalin Márta, Szilárd Váncsa, Rita Nagy, Brigitta Teutsch, Stefania Bunduc, Bálint Erőss, László Czakó, Áron Vincze, Ferenc Izbéki, Mária Papp, Béla Merkely, Andrea Szentesi, Peter Hegyi, Hungarian Pancreatic Study Group
Dátum:	2023
ISSN:	0016-5085
Megjegyzések:	Background and aims The in-hospital survival of patients suffering from acute pancreatitis (AP) is 95?98%. However, there is growing evidence that patients discharged after AP may be at risk of serious morbidity and mortality. Here, we aimed to investigate the risk, causes, and predictors of the most severe consequence of the post-AP period: mortality. Methods 2,613, well-characterized patients from twenty-five centers were collected and followed by the Hungarian Pancreatic Study Group between 2012 and 2021. A general and a hospital-based population was used as the control group. Results After an AP episode patients have an approximately three-fold higher incidence rate of mortality than the general population (0.0404 vs. 0.0130 person-years). First-year mortality after discharge was almost double than in-hospital mortality (5.5% vs. 3.5%), with 3.0% occurring in the first 90-day period. Age, comorbidities, and severity were the most significant independent risk factors for death following AP. Furthermore, multivariate analysis identified creatinine, glucose, and pleural fluid on admission as independent risk factors associated with post-discharge mortality. In the first 90-day period, cardiac failure and AP-related sepsis were among the main causes of death following discharge, while cancer-related cachexia and non-AP-related infection were the key causes in the later phase. Conclusion Almost as many patients in our cohort die in the first 90-day period after discharge asduring their hospital stay. Evaluation of cardiovascular status, follow-up of local complications, and cachexia-preventing oncological care should be an essential part of post-AP patient care. Future study protocols in AP must include at least a 90-day follow-up period after discharge.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Gastroenterology. - 165 : 3 (2023), p. 682-695. -
További szerzők:	Váradi Alex (1991-) (biológus) Farkas Nelli Nyári Gergely Róbert Márta Katalin Váncsa Szilárd Nagy Rita Teutsch Brigitta Bunduc, Stefania Erőss Bálint Czakó László Vincze Áron Izbéki Ferenc Papp Mária (1975-) (belgyógyász, gasztroenterológus) Merkely Béla (1965-) (orvos) Szentesi Andrea Hegyi Péter Jr. (belgyógyász) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Hungarian Pancreatic Study Group
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001-es BibID:	BIBFORM113608
035-os BibID:	(cikkazonosító)711 (scopus)85153749710 (wos)000978970200001
Első szerző:	Dohos Dóra
Cím:	Hungarian Linguistic, Cross-Cultural and Age Adaptation of Transition Specific Questionnaires in Patients with Inflammatory Bowel Disease / Dohos Dóra, Váradi Alex, Farkas Nelli, Erős Adrienn, Müller Katalin Eszter, Karoliny Anna, Gombos Eszter, Nemes Éva, Vass Noémi, Tárnok András, Hegyi Péter, Sarlós Patrícia
Dátum:	2023
ISSN:	2227-9067
Megjegyzések:	Objective: In the TRANS?IBD clinical trial, the outcomes are measured with selected validated questionnaires. Cross-cultural and age adaptations of the Self-Efficacy Scale for adolescents and young adults (IBD?SES), the Transition Readiness Assessment Questionnaire (TRAQ), and the Self Management and Transition Readiness Questionnaire (STARx) were performed. Methods: Linguistic and cultural adaptation was carried out with the usage of reliability coefficients (Cronbach's ? coefficients, Spearman's rank correlation), and with confirmatory factor analysis (CFA; root Mean Square Error of Approximation [RMSEA], Comparative Fit Index [CFI], and Tucker-Lewis Index [TLI]). Results: 112 adolescents participated in the study (45.5% male, mean age 17 ? 1.98 years ). CFA was acceptable in the IBD?SES and the TRAQ. Internal consistency was acceptable in IBD? SES and good in TRAQ (0.729; 0.865, respectively). Test?retest reliability was good in IBD?SES, but below the acceptable threshold in TRAQ (? = 0.819; ? = 0.034). In STARx tools, RMSEA showed poor fit values, CFI and TLI were below acceptable fit values, and internal consistency was not satisfied (0.415; 0.693, respectively), while test?retest reliabilities were acceptable (? = 0.787; ? = 0.788, respectively). Conclusions: Cross-cultural, age-specific adaptation was successfully completed with IBD?SES and TRAQ. Those are comparable to the original validated versions. The adaption of the STARx tools was not successful.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Children. - 10 : 4 (2023), p. 1-14. -
További szerzők:	Váradi Alex (1991-) (biológus) Farkas Nelli Erős Adrienn Müller Katalin Eszter Karoliny Anna Gombos Eszter (1963-) (történelem, német, filozófia, informatika szakos pedagógus) Nemes Éva (1957-) (csecsemő- és gyermekgyógyász, gasztroenterológus) Vass Noémi Tárnok András Hegyi Péter Jr. (belgyógyász) Sarlós Patrícia
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001-es BibID:	BIBFORM105425
035-os BibID:	(scopus)85139358640
Első szerző:	Dohos Dóra
Cím:	Inflammatory bowel disease does not alter the clinical features and the management of acute pancreatitis : A prospective, multicentre, exact-matched cohort analysis / Dora Dohos, Nelli Farkas, Alex Varadi, Balint Erőss, Andrea Parniczky, Andrea Szentesi, Peter Hegyi, Patrícia Sarlos, Hungarian Pancreatic Study Group
Dátum:	2022
ISSN:	1424-3903
Megjegyzések:	Objective and aims: Acute pancreatitis in inflammatory bowel disease occurs mainly as an extraintestinal manifestation or a side effect of medications. We aimed to investigate the prognostic factors and severity indicators of acute pancreatitis and the treatment of patients with both diseases. Design: We performed a matched case-control registry analysis of a multicentre, prospective, interna tional acute pancreatitis registry. Patients with both diseases were matched to patients with acute pancreatitis only in a 1:3 ratio by age and gender. Subgroup analyses were also carried out based on disease type, activity, and treatment of inflammatory bowel disease. Results: No difference in prognostic factors (laboratory parameters, bedside index of severity in acute pancreatitis, imaging results) and outcomes of acute pancreatitis (length of hospitalization, severity, and local or systemic complications) were detected between groups. Significantly lower analgesic use was observed in the inflammatory bowel disease population. Antibiotic use during acute pancreatitis was significantly more common in the immunosuppressed group than in the non-immunosuppressed group (p ? 0.017). However, none of the prognostic parameters or the severity indicators showed a significant difference between any subgroup of patients with inflammatory bowel disease. Conclusion: No significant differences in the prognosis and severity of acute pancreatitis could be detected between patients with both diseases and with pancreatitis only. The need for different acute pancreatitis management is not justified in the coexistence of inflammatory bowel disease, and antibiotic overuse should be avoided. ? 2022 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Pancreatology. - 22 : 8 (2022), p. 1071-1078. -
További szerzők:	Farkas Nelli Váradi Alex (1991-) (biológus) Erőss Bálint Párniczky Andrea (gyermekgyógyász) Szentesi Andrea Hegyi Péter Jr. (belgyógyász) Sarlós Patrícia Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hungarian Pancreatic Study Group
Pályázati támogatás:	ÚNKP-21-5-PTE-1341 Egyéb FK 132834 Egyéb FK 138929 Egyéb ÚNKP-21-5 Egyéb
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001-es BibID:	BIBFORM094178
035-os BibID:	(WOS)000727779500019 (Scopus)85106978919
Első szerző:	Szakó Lajos
Cím:	Early occurrence of pseudocysts in acute pancreatitis - A multicenter international cohort analysis of 2275 cases / Lajos Szakó, Noémi Gede, Alex Váradi, Benedek Tinusz, Nóra Vörhendi, Dóra Mosztbacher, Áron Vincze, Tamás Takács, László Czakó, Ferenc Izbéki, László Gajdán, Veronika Dunás-Varga, József Hamvas, Mária Papp, Krisztina Eszter Fehér, Márta Varga, Artautas Mickevicius, Imola Török, Klementina Ocskay, Márk Félix Juhász, Szilárd Váncsa, Nándor Faluhelyi, Orsolya Farkas, Attila Miseta, András Vereczkei, Alexandra Mikó, Péter Jenő Hegyi, Andrea Szentesi, Andrea Párniczky, Bálint Erőss, Péter Hegyi
Dátum:	2021
ISSN:	1424-3903
Megjegyzések:	BACKGROUND Pseudocysts being the most frequent local complications of acute pancreatitis (AP) have substantial effect on the disease course, hospitalization and quality of life of the patient. Our study aimed to understand the effects of pre existing (OLD-P) and newly developed (NEW-P) pseudocysts on AP. METHODS Data were extracted from the Acute Pancreatitis Registry organized by the Hungarian Pancreatic Study Group (HPSG). 2275 of 2461 patients had uploaded information concerning pancreatic morphology assessed by imaging technique. Patients were divided into "no pseudocyst" (NO-P) group, "old pseudocyst" (OLD-P) group, or "newly developed pseudocyst" (NEW-P) groups. RESULTS The median time of new pseudocyst development was nine days from hospital admission and eleven days from the beginning of the abdominal pain. More NEW-P cases were severe (15.9% vs 4.7% in the NO-P group p<0.001), with longer length of hospitalization (LoH) (median: 14 days versus 8 days, p<0.001), and were associated with several changed laboratory parameters. OLD-P was associated with male gender (72.2% vs. 56.1%, p=0.0014), alcoholic etiology (35.2% vs. 19.8% in the NO-P group), longer hospitalization (median: 10 days, p<0.001), a previous episode of AP (p<0.001), pre-existing diagnosis of chronic pancreatitis (CP) (p<0.001), current smoking (p<0.001), and increased alcohol consumption (unit/week) (p=0.014). CONCLUSION Most of the new pseudocysts develop within two weeks. Newly developing pseudocysts are associated with a more severe disease course and increased length of hospitalization. Pre-existing pseudocysts are associated with higher alcohol consumption and smoking. Because CP is more frequently associated with a pre-existing pseudocyst, these patients need closer attention after AP.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Pancreatology. - 21 : 6 (2021), p. 1161-1172. -
További szerzők:	Gede Noémi Váradi Alex (1991-) (biológus) Tinusz Benedek Vörhendi Nóra Mosztbacher Dóra Vincze Áron Takács Tamás (Szeged) Czakó László Izbéki Ferenc Gajdán László Dunás-Varga Veronika Hamvas József Papp Mária (1975-) (belgyógyász, gasztroenterológus) Fehér Krisztina Eszter Varga Márta Mickevicius, Artautas Török Imola Ocskay Klementina Juhász Márk Félix Váncsa Szilárd Faluhelyi Nándor Farkas Orsolya Miseta Attila Vereczkei András Mikó Alexandra Hegyi Péter Jr. (belgyógyász) Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Erőss Bálint Hegyi Péter Jenő (belgyógyász)
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