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001-es BibID:	BIBFORM111659
035-os BibID:	(Scopus)85166916995
Első szerző:	Czapári Dóra
Cím:	Detailed characteristics of post-discharge mortality in acute pancreatitis / Dóra Czapári, Alex Váradi, Nelli Farkas, Gergely Nyári, Katalin Márta, Szilárd Váncsa, Rita Nagy, Brigitta Teutsch, Stefania Bunduc, Bálint Erőss, László Czakó, Áron Vincze, Ferenc Izbéki, Mária Papp, Béla Merkely, Andrea Szentesi, Peter Hegyi, Hungarian Pancreatic Study Group
Dátum:	2023
ISSN:	0016-5085
Megjegyzések:	Background and aims The in-hospital survival of patients suffering from acute pancreatitis (AP) is 95?98%. However, there is growing evidence that patients discharged after AP may be at risk of serious morbidity and mortality. Here, we aimed to investigate the risk, causes, and predictors of the most severe consequence of the post-AP period: mortality. Methods 2,613, well-characterized patients from twenty-five centers were collected and followed by the Hungarian Pancreatic Study Group between 2012 and 2021. A general and a hospital-based population was used as the control group. Results After an AP episode patients have an approximately three-fold higher incidence rate of mortality than the general population (0.0404 vs. 0.0130 person-years). First-year mortality after discharge was almost double than in-hospital mortality (5.5% vs. 3.5%), with 3.0% occurring in the first 90-day period. Age, comorbidities, and severity were the most significant independent risk factors for death following AP. Furthermore, multivariate analysis identified creatinine, glucose, and pleural fluid on admission as independent risk factors associated with post-discharge mortality. In the first 90-day period, cardiac failure and AP-related sepsis were among the main causes of death following discharge, while cancer-related cachexia and non-AP-related infection were the key causes in the later phase. Conclusion Almost as many patients in our cohort die in the first 90-day period after discharge asduring their hospital stay. Evaluation of cardiovascular status, follow-up of local complications, and cachexia-preventing oncological care should be an essential part of post-AP patient care. Future study protocols in AP must include at least a 90-day follow-up period after discharge.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Gastroenterology. - 165 : 3 (2023), p. 682-695. -
További szerzők:	Váradi Alex (1991-) (biológus) Farkas Nelli Nyári Gergely Róbert Márta Katalin Váncsa Szilárd Nagy Rita Teutsch Brigitta Bunduc, Stefania Erőss Bálint Czakó László Vincze Áron Izbéki Ferenc Papp Mária (1975-) (belgyógyász, gasztroenterológus) Merkely Béla (1965-) (orvos) Szentesi Andrea Hegyi Péter Jr. (belgyógyász) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Hungarian Pancreatic Study Group
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001-es BibID:	BIBFORM103703
035-os BibID:	(cikkazonosító)2131 (Scopus)85130241509 (WoS)000803398400001
Első szerző:	Nagy Rita
Cím:	In-Hospital Patient Education Markedly Reduces Alcohol Consumption after Alcohol-Induced Acute Pancreatitis / Nagy Rita, Ocskay Klementina, Váradi Alex, Papp Mária, Vitális Zsuzsanna, Izbéki Ferenc, Boros Eszter, Gajdán László, Szentesi Andrea, Erőss Bálint, Hegyi Péter Jenő, Vincze Áron, Bajor Judit, Sarlos Patricia, Mikó Alexandra, Márta Katalin, Pécsi Dániel, Párniczky Andrea, Hegyi Péter
Dátum:	2022
ISSN:	2072-6643
Megjegyzések:	Although excessive alcohol consumption is by far the most frequent cause of recurrent acute pancreatitis (AP) cases, specific therapy is still not well established to prevent recurrence. Generally, psychological therapy (e.g., brief intervention (BI)) is the cornerstone of cessation programs; however, it is not yet widely used in everyday practice. We conducted a post-hoc analysis of a prospectively collected database. Patients suffering from alcohol-induced AP between 2016 and 2021 received 30 min BI by a physician. Patient-reported alcohol consumption, serum gamma-glutamyl-transferase (GGT) level, and mean corpuscular volume (MCV) of red blood cells were collected on admission and at the 1-month follow-up visit to monitor patients' drinking habits. Ninety-nine patients with alcohol-induced AP were enrolled in the study (mean age: 50 ? 11, 89% male). A significant decrease was detected both in mean GGT value (294 ? 251 U/L vs. 103 ? 113 U/L, p < 0.001) and in MCV level (93.7 ? 5.3 U/L vs. 92.1 ? 5.1 U/L, p < 0.001) in patients with elevated on-admission GGT levels. Notably, 79% of the patients (78/99) reported alcohol abstinence at the 1-month control visit. Brief intervention is an effective tool to reduce alcohol consumption and to prevent recurrent AP. Longitudinal randomized clinical studies are needed to identify the adequate structure and frequency of BIs in alcohol-induced AP
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Nutrients. - 14 : 10 (2022), p. 1-9. -
További szerzők:	Ocskay Klementina Váradi Alex (1991-) (biológus) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Izbéki Ferenc Boros Eszter Gajdán László Szentesi Andrea Erőss Bálint Hegyi Péter Jenő (belgyógyász) Vincze Áron Bajor Judit Sarlós Patrícia Mikó Alexandra Márta Katalin Pécsi Dániel Párniczky Andrea (gyermekgyógyász) Hegyi Péter (pszichológus)
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001-es BibID:	BIBFORM113553
035-os BibID:	(scopus)85153309480 (wos)000973548200001
Első szerző:	Váncsa Szilárd
Cím:	Metabolic-associated fatty liver disease is associated with acute pancreatitis with more severe course : Post hoc analysis of a prospectively collected international registry / Váncsa Szilárd, Sipos Zoltán, Váradi Alex, Nagy Rita, Ocskay Klementina, Juhász Félix Márk, Márta Katalin, Teutsch Brigitta, Mikó Alexandra, Hegyi Péter Jenő, Vincze Áron, Izbéki Ferenc, Czakó László, Papp Mária, Hamvas József, Varga Márta, Török Imola, Mickevicius Artautas, Erőss Bálint, Párniczky Andrea, Szentesi Andrea, Pár Gabriella, Hegyi Péter, Hungarian Pancreatic Study Group
Dátum:	2023
ISSN:	2050-6406 2050-6414
Megjegyzések:	Introduction - Non?alcoholic fatty liver disease (NAFLD) is a proven risk factor for acute pancreatitis (AP). However, NAFLD has recently been redefined as metabolic?associated fatty liver disease (MAFLD). In this post hoc analysis, we quantified the effect of MAFLD on the outcomes of AP. Methods - We identified our patients from the multicentric, prospective International Acute Pancreatitis Registry of the Hungarian Pancreatic Study Group. Next, we compared AP patients with and without MAFLD and the individual components of MAFLD regarding in?hospital mortality and AP severity based on the revised Atlanta classification. Lastly, we calculated odds ratios (ORs) with 95% confidence intervals (CIs) using multivariate logistic regression analysis. Results - MAFLD had a high prevalence in AP, 39% (801/2053). MAFLD increased the odds of moderate?to?severe AP (OR = 1.43, CI: 1.09?1.89). However, the odds of in?hospital mortality (OR = 0.89, CI: 0.42?1.89) and severe AP (OR = 1.70, CI: 0.97?3.01) were not higher in the MAFLD group. Out of the three diagnostic criteria of MAFLD, the highest odds of severe AP was in the group based on metabolic risk abnormalities (OR = 2.68, CI: 1.39?5.09). In addition, the presence of one, two, and three diagnostic criteria dose?dependently increased the odds of moderate?to?severe AP (OR = 1.23, CI: 0.88?1.70, OR = 1.38, CI: 0.93?2.04, and OR = 3.04, CI: 1.63?5.70, respectively) and severe AP (OR = 1.13, CI: 0.54?2.27, OR = 2.08, CI: 0.97?4.35, and OR = 4.76, CI: 1.50?15.4, respectively). Furthermore, in patients with alcohol abuse and aged ?60 years, the effect of MAFLD became insignificant. Conclusions - MAFLD is associated with AP severity, which varies based on the components of its diagnostic criteria. Furthermore, MAFLD shows a dose? dependent effect on the outcomes of AP.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	United European Gastroenterology Journal. - 11 : 4 (2023), p. 371-382. -
További szerzők:	Sipos Zoltán (1988-) (vegyész, angol-magyar szakfordító) Váradi Alex (1991-) (biológus) Nagy Rita Ocskay Klementina Juhász Márk Félix Márta Katalin Teutsch Brigitta Mikó Alexandra Hegyi Péter Jenő (belgyógyász) Vincze Áron Izbéki Ferenc Czakó László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hamvas József Varga Márta Török Imola Mickevicius, Artautas Erőss Bálint Párniczky Andrea (gyermekgyógyász) Szentesi Andrea Pár Gabriella Hegyi Péter (pszichológus) Hungarian Pancreatic Study Group
Pályázati támogatás:	ÚNKP?22?3?II Egyéb ÚNKP?22?3?I Egyéb ÚNKP?22?5 Egyéb ÚNKP?22?4?II Egyéb FK131864 Egyéb
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