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1.

001-es BibID:BIBFORM119418
035-os BibID:(cikkazonosító)3238
Első szerző:Pikó Péter (biológus)
Cím:Genetic Background of Acute Heart Rate Response to Exercise / Péter Pikó, Habib Al Ashkar, Nóra Kovács, Ilona Veres-Balajti, Róza Ádány
Dátum:2024
ISSN:1422-0067
Megjegyzések:The acute heart rate response (AHRR) to physical activity, which refers to the change in heart rate during and after exercise, has been associated with cardiovascular and all-cause mortality. Previous studies have shown that AHRR is significantly determined by genetics in addition to environmental and lifestyle factors. The aim of this study was to investigate the genetic background of AHRR by analysing ten single nucleotide polymorphisms (SNPs) associated with leisure-time physical activity (LTPA) in 620 samples from the Hungarian population. The AHRR can be characterised as the difference between post-exercise and resting heart rate, i.e., the delta heart rate (?HR) defined by the YMCA 3 min step test, with a lower value indicating better cardiovascular fitness. The association of SNPs with ?HR was analysed both separately and in combination using an optimised polygenic score (oPGS). The results showed that five SNPs (rs10252228, rs459465, rs6022999, rs8097348, and rs12405556) had at least nominally significant (p < 0.05) individual associations with ?HR. After optimizing the PGS, a cumulative effect was observed for eight SNPs (rs6022999, rs12405556, rs459465, rs10252228, rs8097348, rs10887741, rs12612420, and rs7023003) that had a strong and statistically significant association with ?HR (B = ?2.51, 95% CI: ?3.46??1.76; p = 2.99 ? 10?9). Of the four main domains of physical activity, the oPGS showed a significant positive association only with LTPA (B = 84.60; 95%CI: 25.23?143.98; p = 0.005). In conclusion, our results suggest that the SNPs we investigated influence individual leisure-time physical activity, mediated by their effects on the acute heart rate response.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
acute heart rate response
cardiorespiratory fitness
YMCA 3 min step test
optimised polygenic score
single nucleotide polymorphism
leisure-time physical activity
Megjelenés:International Journal Of Molecular Sciences. - 25 : 6 (2024), p. 1-12. -
További szerzők:Al Ashkar, Habib Kovács Nóra (1989-) (népegészségügyi szakember) Veres-Balajti Ilona (1965-) (gyógytornász, egészségfejlesztő) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
TK2016-78
MTA
TKCS-2021/32
Egyéb
135784
OTKA
National Research, Development, and Innovation Office (NKFIH) RRF-2.3.1-21-2022-00006
Egyéb
ÚNKP-23-5-DE-494
Egyéb
BO/00513/23/5
MTA
Internet cím:Szerző által megadott URL
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Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM114677
035-os BibID:(cikkazonosító)10281 (scopus)85164039480 (wos)001015071200001
Első szerző:Pikó Péter (biológus)
Cím:Association of CETP Gene Polymorphisms and Haplotypes with Cardiovascular Risk / Piko Peter, Jenei Tibor, Kosa Zsigmond, Sandor Janos, Kovacs Nora, Seres Ildiko, Paragh Gyorgy, Adany Roza
Dátum:2023
ISSN:1422-0067
Megjegyzések:Cholesteryl ester transfer protein (CETP) is known to influence HDL-C levels, potentially altering the profile of HDL subfractions and consequently cardiovascular risk (CVR). This study aimed to investigate the effect of five single-nucleotide polymorphisms (SNPs; rs1532624, rs5882, rs708272, rs7499892, and rs9989419) and their haplotypes (H) in the CETP gene on 10-year CVR estimated by the Systematic Coronary Risk Evaluation (SCORE), the Framingham Risk Score for Coronary Heart Disease (FRSCHD) and Cardiovascular Disease (FRSCVD) algorithms. Adjusted linear and logistic regression analyses were used to investigate the association of SNPs and 10 haplotypes (H1-H10) on 368 samples from the Hungarian general and Roma populations. The T allele of rs7499892 showed a significant association with increased CVR estimated by FRS. H5, H7, and H8 showed a significant association with increased CVR based on at least one of the algorithms. The impact of H5 was due to its effect on TG and HDL-C levels, while H7 showed a significant association with FRSCHD and H8 with FRSCVD mediated by a mechanism affecting neither TG nor HDL-C levels. Our results suggest that polymorphisms in the CETP gene may have a significant effect on CVR and that this is not mediated exclusively by their effect on TG and HDL-C levels but also by presently unknown mechanisms.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Framingham Risk Score
HDL subfraction profile
Systematic Coronary Risk Evaluation
cholesteryl ester transfer protein
haplotype
high-density lipoprotein cholesterol
single-nucleotide polymorphism
Megjelenés:International Journal Of Molecular Sciences. - 24 : 12 (2023), p. 1-16. -
További szerzők:Jenei Tibor (1963-) (programtervező informatikus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Kovács Nóra (1989-) (népegészségügyi szakember) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
135784
OTKA
TK2016-78
Egyéb
TKCS-2021/32
Egyéb
ÚNKP-22-4-II-DE-268
Egyéb
RRF-2.3.1-21-2022-00006
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM114678
035-os BibID:(cikkazonosító)13563 (scopus)85170209245 (wos)001060602800001
Első szerző:Pikó Péter (biológus)
Cím:Association of HDL Subfraction Profile with the Progression of Insulin Resistance / Piko Peter, Jenei Tibor, Kosa Zsigmond, Sandor Janos, Kovacs Nora, Seres Ildiko, Paragh Gyorgy, Adany Roza
Dátum:2023
ISSN:1422-0067
Megjegyzések:Type 2 diabetes mellitus (T2DM) is a major global public health problem, as it is associated with increased morbidity, mortality, and healthcare costs. Insulin resistance (IR) is a condition characterized by disturbances in carbohydrate and lipid metabolism that precedes T2DM. The aim of the present study was to investigate the association between HDL and its subfraction profile and the progression of IR, as assessed by the Homeostatic Model Assessment for IR (HOMA-IR) index, and to define cut-off values to identify an increased risk of IR. Individuals with a HOMA-IR greater than 3.63 were considered to have IR. The HDL subfractions were separated using the Lipoprint system, which identifies ten subfractions (HDL-1-10) in three subclasses as large (HDL-L), intermediate (HDL-I) and small (HDL-S). Analyses were performed on samples from 240 individuals without IR and 137 with IR from the Hungarian general and Roma populations. The HDL-1 to -6 subfractions and the HDL-L and -I classes showed a significant negative association with the progression and existence of IR. Among them, HDL-2 (B = -40.37, p = 2.08 ? 10-11) and HDL-L (B = -14.85, p = 9.52 ? 10-10) showed the strongest correlation. The optimal threshold was found to be 0.264 mmol/L for HDL-L and 0.102 mmol/L and above for HDL-2. Individuals with HDL-L levels below the reference value had a 5.1-fold higher risk of IR (p = 2.2 ? 10-7), while those with HDL-2 levels had a 4.2-fold higher risk (p = 3.0 ? 10-6). This study demonstrates that the HDL subfraction profile (especially the decrease in HDL-2 and -L) may be a useful marker for the early detection and intervention of atherogenic dyslipidemia in subjects with impaired glucose and insulin metabolism.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
insulin resistance
HDL subfraction profile
HDL-2
large HDL
cut-off points
HOMA-IR
diabetes
high-density lipoprotein cholesterol
Megjelenés:International Journal Of Molecular Sciences. - 24 : 17 (2023), p. 1-13. -
További szerzők:Jenei Tibor (1963-) (programtervező informatikus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Kovács Nóra (1989-) (népegészségügyi szakember) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
135784
OTKA
TK2016-78
Egyéb
TKCS-2021/32
Egyéb
ÚNKP-22-4-II-DE-268
Egyéb
RRF-2.3.1-21-2022-00006
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM110622
035-os BibID:(cikkazonosító)5209 (scopus)85151435418 (wos)000957873700001
Első szerző:Pikó Péter (biológus)
Cím:Genetic Background of Metabolically Healthy and Unhealthy Obesity Phenotypes in Hungarian Adult Sample Population / Piko Peter, Llanaj Erand, Nagy Karoly, Adany Roza
Dátum:2023
ISSN:1422-0067
Megjegyzések:A specific phenotypic variant of obesity is metabolically healthy (MHO), which is characterized by normal blood pressure and lipid and glucose profiles, in contrast to the metabolically unhealthy variant (MUO). The genetic causes underlying the differences between these phenotypes are not yet clear. This study aims to explore the differences between MHO and MUO and the contribution of genetic factors (single nucleotide polymorphisms?SNPs) in 398 Hungarian adults (81 MHO and 317 MUO). For this investigation, an optimized genetic risk score (oGRS) was calculated using 67 SNPs (related to obesity and to lipid and glucose metabolism). Nineteen SNPs were identified whose combined effect was strongly associated with an increased risk of MUO (OR = 1.77, p < 0.001). Four of them (rs10838687 in MADD, rs693 in APOB, rs1111875 in HHEX, and rs2000813 in LIPG) significantly increased the risk of MUO (OR = 1.76, p < 0.001). Genetic risk groups based on oGRS were significantly associated with the risk of developing MUO at a younger age. We have identified a cluster of SNPs that contribute to the development of the metabolically unhealthy phenotype among Hungarian adults suffering from obesity. Our findings emphasize the significance of considering the combined effect(s) of multiple genes and SNPs in ascertaining cardiometabolic risk in obesity in future genetic screening programs.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
optimized genetic risk score
metabolically unhealthy obesity
metabolically healthy obesity
Hungarian population
Lipid metabolism
Glucose metabolism
Megjelenés:International Journal Of Molecular Sciences. - 24 : 6 (2023), p. 1-16. -
További szerzők:Llanaj, Erand (1988-) (táplálkozási epidemiológus) Nagy Károly (1986-) (népegészségügyi felügyelő) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM109123
035-os BibID:(cikkazonosító)4566 (WoS)000947319300001 (Scopus)85149877208
Első szerző:Pikó Péter (biológus)
Cím:Genetic Determinants of Leisure-Time Physical Activity in the Hungarian General and Roma Populations / Pikó Péter, Bácsné Bába Éva, Kósa Zsigmond, Sándor János, Kovács Nóra, Bács Zoltán, Ádány Róza
Dátum:2023
ISSN:1422-0067
Megjegyzések:Leisure-time physical activity (LTPA) is one of the modifiable lifestyle factors that play an important role in the prevention of non-communicable (especially cardiovascular) diseases. Certain genetic factors predisposing to LTPA have been previously described, but their effects and applicability on different ethnicities are unknown. Our present study aims to investigate the genetic background of LTPA using seven single nucleotide polymorphisms (SNPs) in a sample of 330 individuals from the Hungarian general (HG) and 314 from the Roma population. The LTPA in general and three intensity categories of it (vigorous, moderate, and walking) were examined as binary outcome variables. Allele frequencies were determined, individual correlations of SNPs to LTPA, in general, were determined, and an optimized polygenetic score (oPGS) was created. Our results showed that the allele frequencies of four SNPs differed significantly between the two study groups. The C allele of rs10887741 showed a significant positive correlation with LTPA in general (OR = 1.48, 95% CI: 1.12?1.97; p = 0.006). Three SNPs (rs10887741, rs6022999, and rs7023003) were identified by the process of PGS optimization, whose cumulative effect shows a strong significant positive association with LTPA in general (OR = 1.40, 95% CI: 1.16?1.70; p < 0.001). The oPGS showed a significantly lower value in the Roma population compared with the HG population (oPGSRoma: 2.19 SD: 0.99 vs. oPGSHG: 2.70 SD: 1.06; p < 0.001). In conclusion, the coexistence of genetic factors that encourage leisure-time physical activity shows a more unfavorable picture among Roma, which may indirectly contribute to their poor health status.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
genetics
leisure-time physical activity
polygenic score
Roma population
Hungarian population
Megjelenés:International Journal Of Molecular Sciences. - 24 : 5 (2023), p. 1-14. -
További szerzők:Bácsné Bába Éva (1968-) (bölcsésztanár, szakközgazda) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Kovács Nóra (1989-) (népegészségügyi szakember) Bács Zoltán (1969-) (agrármérnök) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2- 15-2016-00005
Egyéb
TK2016-78
Egyéb
TKCS-2021/32
Egyéb
135784
OTKA
ÚNKP-22-4-II-DE-268
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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