CCL

Összesen 1 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM086819
035-os BibID:(cikkazonosító)e0234547 (WOS)000542759600049 (Scopus)85086691856
Első szerző:Soltész Beáta
Cím:The genetic risk for hypertension is lower among the Hungarian Roma population compared to the general population / Beáta Soltész, Péter Pikó, János Sándor, Zsigmond Kósa, Róza Ádány, Szilvia Fiatal
Dátum:2020
ISSN:1932-6203
Megjegyzések:Estimating the prevalence of cardiovascular diseases (CVDs) and risk factors among the Roma population, the largest minority in Europe, and investigating the role of genetic or environmental/behavioral risk factors in CVD development are important issues in countries where they are significant minority. This study was designed to estimate the genetic susceptibility of the Hungarian Roma (HR) population to essential hypertension (EH) and compare it to that of the general (HG) population. Twenty EH associated SNPs (in AGT, FMO3, MTHFR-NPPB, NPPA, NPPA-AS1, AGTR1, ADD1, NPR3-C5orf23, NOS3, CACNB2, PLCE1, ATP2B1, GNB3, CYP1A1-ULK3, UMOD and GNAS-EDN3) were genotyped using DNA samples obtained from HR (N = 1176) and HG population (N = 1178) subjects assembled by cross-sectional studies. Allele frequencies and genetic risk scores (unweighted and weighted genetic risk scores (GRS and wGRS, respectively) were calculated for the study groups and compared to examine the joint effects of the SNPs. The susceptibility alleles were more frequent in the HG population, and both GRS and wGRS were found to be higher in the HG population than in the HR population (GRS: 18.98 ? 3.05 vs. 18.25 ? 2.97, p<0.001; wGRS: 1.4 [IQR: 0.93?1.89] vs. 1.52 [IQR: 0.99?2.00], p<0.01). Twenty-seven percent of subjects in the HR population were in the bottom fifth (GRS ? 16) of the risk allele count compared with 21% of those in the HG population. Thirteen percent of people in the HR group were in the top fifth (GRS ? 22) of the GRS compared with 21% of those in the HG population (p<0.001), i.e., the distribution of GRS was found to be left-shifted in the HR population compared to the HG population. The Roma population seems to be genetically less susceptible to EH than the general one. These results support preventive efforts to lower the risk of developing hypertension by encouraging a healthy lifestyle. Helyreigazítás: Plos One. -16 : 7 (2022). -PLoS One. -1932-6203. -1932-6203
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Plos One. - 15 : 6 (2020), p. 1-17. -
További szerzők:Pikó Péter (1987-) (biológus) Sándor János (1966-) (orvos-epidemiológus) Kósa Zsigmond (1953-) (orvos) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
Pályázati támogatás:TÁMOP 4.2.2.A-11/1/KONV-2012-0031
TÁMOP
GINOP-2.3.2-15-2016-00005
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1