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001-es BibID:	BIBFORM108859
035-os BibID:	(WOS)000777053900009 (Scopus)85127290961
Első szerző:	Fekete Mónika
Cím:	Metabolic syndrome in patients with COPD : causes and pathophysiological consequences / Monika Fekete, Gergo Szollosi, Stefano Tarantini, Andrea Lehoczki, Anna N. Nemeth, Csenge Bodola, Luca Varga, Janos Tamas Varga
Dátum:	2022
ISSN:	2498-602X
Megjegyzések:	Background: Decreased physical activity significantly increases the probability of prevalent metabolic syndrome (MetS) with substantial impact on the expected course of COPD. Objective: Our research aims to assess the metabolic consequences of chronic obstructive pulmonary disease (COPD) and evaluate the prevalence of MetS and its interrelations with age, sex, comorbidities, drug intake, degree of decreased lung function, nutritional status, physical activity and quality of life. Methods: A cross-sectional study was performed on a random sample (n = 401) at the Department of Pulmonary Rehabilitation of the National Koranyi Institute of Pulmonology from March 1, 2019 to March 1, 2020 in Budapest, Hungary. Anthropometric and respiratory function tests and laboratory parameters of all patients were registered. Results: MetS occurred in 59.1% of COPD patients with significant gender difference (male: 49.7% female: 67.6%). Concerning BMI, the prevalence of MetS was higher with BMI >= 25 kg m(-2) (P < 0.0001). Patients with this syndrome had significantly worse FEV1%pred (43 (30-56) vs. 47 (36-61); P = 0.028), lower quality of life (CAT: 26 (21-32) vs. 24.5 (19-29); P = 0.049) and significantly more frequent exacerbations (2 (1-3) vs.1 (0-2); P < 0.05), than patients without MetS. The prevalence of comorbidities were higher in overweight/obese patients (BMI> 25 kg m(-2)). Conclusions: In COPD patients MetS negatively affect respiratory function and quality of life and promotes exacerbations of the disease. MetS is related to nutritional status and the level of systemic inflammation in COPD patients.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény hazai lapban folyóiratcikk
Megjelenés:	Physiology International. - 109 : 1 (2022), p. 90-105. -
További szerzők:	Szőllősi Gergő József (1991-) (népegészségügyi ellenőr, népegészségügyi szakember) Tarantini, Stefano Lehoczki Andrea Németh Anna Noémi Bodola Csenge Varga Luca Varga János Tamás (Budapest)
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001-es BibID:	BIBFORM102829
035-os BibID:	(WOS)000614299200003 (Scopus)85099241109
Első szerző:	Fekete Mónika
Cím:	Az ómega-3 zsírsavak pótlásának klinikai értéke krónikus obstruktív tüdőbetegségben / Fekete Mónika, Szőllősi Gergő, Németh Anna Noémi, Varga János Tamás
Dátum:	2021
ISSN:	0030-6002 1788-6120
Megjegyzések:	Introduction: Our civilized world, while seems to be overweight, suffers from omega-3 deficiency. Long-chain polyunsaturated fatty acids can play a role in the development of many metabolic diseases (e.g., obesity, type 2 diabetes mellitus, cardiovascular disease). Fatty acids in fish oil strengthen the immune system, reduce cholesterol and triglyceride levels, have been proven to be beneficial, reduce inflammation. Objective: The aim of our study was to monitor the intake of polyunsaturated fatty acids and to evaluate their relationship with lung function and quality of life in patients with chronic obstructive pulmonary disease (COPD). Method: Our questionnaire was completed at the Department of Pulmonary Rehabilitation of the National Koranyi Institute for Pulmonology between March 1, 2019 and March 1, 2020 among COPD patients over 40 years of age. We used the disease-specific St. George's Respiratory Questionnaire to measure the quality of life; the respiratory function and anthropometric data were extracted from the electronic health record system. Results: The median age of the patients was 66 (IQR 60-73) years, with a gender division of 47.5% male and 52.5% female. The median BMI was 26.0 (IQR 21.7-30.6) kg/m2, and the median FEV1 (%pred) was 48.0 (IQR 38.1-55.3). In the form of a dietary supplement, 4.7% (n = 19) of patients take omega-3 fatty acids regularly, mainly on the recommendation of their doctor, at the recommended daily dose (0.25-0.50 g/day). Among them, we detected a better quality of life (65.8 [52.4-79.7] vs. 72.2 [56.2-88.6]; p = 0.044), had fewer comorbidities (hypertension: 10 [52.6%] vs. 275 [72.1%]; p = 0.066), consumed fewer drugs (short-acting bronchodilators: 5 [25.3%] vs. 197 [51.7%]; p = 0.031), had fewer exacerbations (1 [1-3] vs. 2 [1-4]; p = 0.029), and higher six-minute walking distance (300 [177-387] vs. 251 [150-345]; p = 0.121). Conclusion: Our results suggest that the intake of polyunsaturated fatty acids may be related to the quality of life in COPD patients. According to our study, the intake of omega-3 in patients is unsatisfactory, and based on our results, we would like to draw attention to the importance of consuming these fats. © 2021 Akademiai Kiado Rt.. All rights reserved.
Tárgyszavak:	Orvostudományok Egészségtudományok magyar nyelvű folyóiratközlemény hazai lapban folyóiratcikk krónikus obstruktív tüdőbetegség ómega-3 eikozapentaénsav dokozahexaénsav életminőség Chronic obstructive pulmonary disease Docosahexaenoic acid Eicosapentaenoic acid Omega-3 Quality of life
Megjelenés:	Orvosi Hetilap. - 162 : 1 (2021), p. 23-30. -
További szerzők:	Szőllősi Gergő József (1991-) (népegészségügyi ellenőr, népegészségügyi szakember) Németh Anna Noémi Varga János Tamás (Budapest)
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