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001-es BibID:BIBFORM106976
035-os BibID:(Scopus)85139781076 (cikkazonosító)100024
Első szerző:Nagy Cynthia (1994-)
Cím:Top-down proteomic analysis of monoclonal antibodies by capillary zone electrophoresis-mass spectrometry / Cynthia Nagy, Melinda Andrási, Narmin Hamidli, Gyöngyi Gyémánt, Attila Gáspár
Dátum:2022
ISSN:2772-3917
Megjegyzések:Capillary zone electrophoresis (CZE) is considered an alternative to advanced chromatographic methods for the analysis of monoclonal antibodies (mAbs) as those are well applicable for the high-resolution separation of intact proteins, proteoforms or even protein complexes. Thus, CZE with mass spectrometry (MS) detection, has the potential to grow into a powerful analytical platform for the extensive investigation of mAbs. The top-down proteomic approach, where the application of CZE-MS might be exceptionally beneficial, provides the determination of both the accurate molecular mass and several microheterogeneities. Although there is a relatively small number of publications about the CZE-MS of mAbs, the pharmaceutical industry has an unambiguous interest on this field and thorough, intensive research has been initiated. In this review, we surveyed the developments of top-down CZE?MS applied for mAbs. The merits and limitations of the published capillary coatings and running electrolytes used for CZE-MS were discussed. The different aspects of CZE-MS hyphenation, furthermore, the applications of such mAb studies were surveyed, as well.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Chromatography Open. - 2 (2022), p. 1-21. -
További szerzők:Andrási Melinda (1979-) (gyógyszerész) Hamidli, Narmin Gyémánt Gyöngyi (1960-) (vegyész) Gáspár Attila (1970-) (vegyész, kémikus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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