CCL

Összesen 4 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM073024
035-os BibID:(WoS)000366646400029 (Scopus)84951907147
Első szerző:Tóth Dezső (sebész, onkológus)
Cím:Predictive Factors for Positive Margin and the Surgical Learning Curve in Non-Palpable Breast Cancer After Wire-Guided Localization - Prospective Study of 214 Consecutive Patients / Dezső Tóth, Zsolt Varga, Éva Sebő, Miklós Török, Ilona Kovács
Dátum:2016
ISSN:1219-4956 1532-2807
Megjegyzések:To investigate the most commonly used technique, the wire-guided localization (WGL) in non-palpable breast cancer. To analyze the effective factors on positive surgical margins in our practice and determine the surgical learning curve of this method. Prospective consecutive study was performed from January 2005 to December 2011. Inclusion criteria was a non-palpable breast lesion with malignancy on preoperative histology. All lesions were localized by ultrasound or stereotactic guided wire placement. Margins 1 mm or closer were accepted as positive margins which required re-excision. To determine the learning curve of WGL method we investigated the change in the reoperation rate after primary procedure performed by "high-volume" surgeon. Two hundred and fourteen consecutive patients were enrolled. In 23 patients (10.7%) reexcision was needed. Positive surgical margins were significantly influenced by the patient's age (p?=?0.03), tumor volume (p?<?=0.001), proportion of tumor volume/specimen volume (p?<?0.001), presence of DCIS (p?<?0.001), multifocality (p?=?0.03) and the learning curve (p?=?0.006) with univariate analysis. Only the tumor volume, presence of DCIS and the learning curve were proved as independent prognostic factor for reoperation by multivariate analysis. The reoperation rate decreased below 20% after the fortieth operation. Results of our single institutional study suggest, that this localization technique can be performed safely with very good results after 40 procedures as a learning curve for surgeons.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Breast cancer
Learning curve
Non-palpable
Surgery
Wire-guided localization
Megjelenés:Pathology & Oncology Research. - 22 : 1 (2016), p. 209-215. -
További szerzők:Varga Zsolt József (1987-) (orvos) Sebő Éva Török Miklós (1976-) (pathológus) Kovács Ilona (1965-) (patológus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM073028
035-os BibID:(Scopus)85041094885 (WOS)000429808200024
Első szerző:Tóth Dezső (sebész, onkológus)
Cím:Short- and Long-Term (10-year) Results of an Organized, Population-Based Breast Cancer Screening Program : comparative, Observational Study from Hungary / Dezső Tóth, Zsolt Varga, Judit Tóth, Péter Árkosy, Éva Sebő
Dátum:2018
ISSN:0364-2313
Megjegyzések:BACKGROUND:A nationwide breast cancer screening program was introduced in Hungary in the year 2002 for women aged 45-65 years to be performed biannually.METHODS:To investigate and report the short-term and 10-year follow-up results, we analyzed our Breast Unit's prospectively led database of screened (Group A) and age-matched symptomatic (Group B) patients from 2002 to 2007. We compared the clinicopathologic features of tumors and the impact of screening on surgical treatment, as well as the overall (OS), disease-specific (DSS) and disease-free survival (DFS) of different groups.RESULTS:Data from 208 screen-detected and 101 symptomatic patients between 45 and 65 years of age were examined. Screen-detected women were younger (54 vs. 58.5 years; p = 0.001) had significantly smaller tumors (15.5 vs. 17 mm; p = 0.044), and more breast-conserving surgery (68.8 vs. 59.4%; p = 0.032). Survival statistics were not statistically different at the median follow-up of 123 months; however, there was a trend toward improved DFS in Group A (82.7 vs. 74.3%; p = 0.074).CONCLUSIONS:Our study showed a significant reduction in rates of mastectomy in the screen-detected group in the short term, which does not translate into better survival rates based on initial long-term data. In order to realize the real advantage of this newly enstated screening program, a longer period of investigation is needed.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:World Journal Of Surgery. - 42 : 5 (2018), p. 1396-1402. -
További szerzők:Varga Zsolt József (1987-) (orvos) Tóth Judit Árkosy Péter (1962-) (általános sebész, mellkassebész) Sebő Éva
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM113626
035-os BibID:(scopus)85164909420 (wos)001031421700001
Első szerző:Varga Zsolt József (orvos)
Cím:Beyond a decade : a comparative study of 15-year survival rates in screen-detected vs. symptomatic breast cancer patients in Hungary / Varga Zsolt, Balog Klaudia, Sebő Éva, Árkosy Péter, Tóth Dezső
Dátum:2023
ISSN:0021-1265
Megjegyzések:Background: Breast cancer is the leading cancer in women globally. Despite decreasing mortality rates, largely due to early detection and modern treatment, the effectiveness of screening on long-term survival outcomes remains unclear. Aims: This study evaluates the 15-year survival outcomes of a national breast cancer screening program initiated in Hungary in 2002. Methods: Using a prospectively maintained patient database, the study included individuals from the first 6 years of the program who underwent surgery for histologically confirmed breast cancer and had available follow-up information. Patients were categorized based on the method of breast cancer detection into two groups: those diagnosed during or 2 years after the population-based screening exam (Group A), and those who self-detected or sought medical attention for symptoms (Group B). Results: Of the 309 patients who underwent breast cancer surgery, 208 were screen-detected (Group A) and 101 were symptomatic (Group B). The 15-year overall survival was 75.0% for Group A and 76.2% for Group B (p?=?0.927). The 15-year disease-specific survival was 85.6% and 81.2% (p?=?0.249), respectively. A statistically not significant positive trend in disease-free survival was observed in Group A (81.7% vs. 75.2%; p?=?0.144). Conclusions: The study underscores the importance of extended follow-up periods in evaluating the outcomes of breast cancer screening programs. While the screening program may not significantly enhance overall survival rates, it has demonstrated a reduction in the mastectomy rate and could potentially extend periods of disease-free survival. These findings contribute to the ongoing discourse about the long-term benefits of breast cancer screening programs.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Breast cancer
Mammography
Screening
Surgery
Survival
Megjelenés:Irish Journal Of Medical Science. - 2023 (2023), p. 1-7. -
További szerzők:Balog Klaudia (1988-) (sebész szakorvos) Sebő Éva Árkosy Péter (1962-) (általános sebész, mellkassebész) Tóth Dezső (1972-) (sebész, onkológus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM073046
Első szerző:Varga Zsolt József (orvos)
Cím:Breast Cancer in Surgical Site : unusual Presentation of an Ectopic Milk Line Malignancy / Zsolt Varga, Miklós Török, Éva Sebő, Judit Tóth, Dezső Tóth
Dátum:2016
Megjegyzések:Primary ectopic breast cancer is a rare entity, which is mistaken for other benign skin or soft tissue lesions, easily.A 56-year old woman with history of laparoscopic cholecystectomy was referred to outpatient clinic 3 years after the operation with a non- healing reddish lump in the surgical scar. The lesion was situated at the site of the right subcostal port, in the medioclavicular line, below the ribcage. Local excision was performed and histological evaluation revealed poorly differentiated adenocarcinoma, which was thought to be metastatic. After multiple recurrences, appearance of an axillary lymph node metastasis and persistent search without any sign of other tumor, it had to be considered as a possibility, if there is no distant source of metastases, rather than a the lesion is a primary cancer. Relying on its location, behavior and result of immunohistochemistry, multidisciplinary team identi ed the lesion as triple-negative ectopic breast cancer. We performed a radical excision extended to the peritoneum, including partial, 3 cm long resection of the eleventh rib and a level II. Right-sided axillary block dissection was done simultaneously. The abdominal wall was reconstructed with component separation technique combining polypropylene and polytetra uoroethylene meshes. The multidisciplinary team proposed a treatment for triple- negative ectopic milk-line breast cancer, containing 4 cycles of TAC chemotherapy and fractionated 50 Gray dose of local radiotherapy. This adjuvant oncological treatment is in progress.This entity should be considered in differential diagnosis in cases of adenocarcinomas close to normal breasts and in the line of embryonic mammary ridges. So, we can avoid a signi cant delay in treatment and we can offer a better prognosis for the patient.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Breast cancer
Ectopic breast
Aberrant breast tissue
Milk line
Surgery
Megjelenés:International Journal of Cancer and Clinical Research. - 3 : 1 (2016), p. 1-3. -
További szerzők:Török Miklós (1976-) (pathológus) Sebő Éva Tóth Judit Tóth Dezső (1972-) (sebész, onkológus)
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1