CCL

Összesen 7 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM109087
035-os BibID:(WoS)000939624800001 (Scopus)85149044317
Első szerző:Buttia, Chepkoech
Cím:Prognostic models in COVID-19 infection that predict severity : a systematic review / Buttia Chepkoech, Llanaj Erand, Raeisi-Dehkordi Hamidreza, Kastrati Lum, Amiri Mojgan, Meçani Renald, Taneri Petek Eylul, Ochoa Sergio Alejandro Gómez, Raguindin Peter Francis, Wehrli Faina, Khatami Farnaz, Espínola Octavio Pano, Rojas Lyda Z., de Mortanges Aurélie Pahud, Macharia-Nimietz Eric Francis, Alijla Fadi, Minder Beatrice, Leichtle Alexander B., Lüthi Nora, Ehrhard Simone, Que Yok-Ai, Fernandes Laurenz Kopp, Hautz Wolf, Muka Taulant
Dátum:2023
ISSN:0393-2990
Megjegyzések:Current evidence on COVID-19 prognostic models is inconsistent and clinical applicability remains controversial. We per- formed a systematic review to summarize and critically appraise the available studies that have developed, assessed and/or validated prognostic models of COVID-19 predicting health outcomes. We searched six bibliographic databases to identify published articles that investigated univariable and multivariable prognostic models predicting adverse outcomes in adult COVID-19 patients, including intensive care unit (ICU) admission, intubation, high-flow nasal therapy (HFNT), extracor- poreal membrane oxygenation (ECMO) and mortality. We identified and assessed 314 eligible articles from more than 40 countries, with 152 of these studies presenting mortality, 66 progression to severe or critical illness, 35 mortality and ICU admission combined, 17 ICU admission only, while the remaining 44 studies reported prediction models for mechanical ventilation (MV) or a combination of multiple outcomes. The sample size of included studies varied from 11 to 7,704,171 participants, with a mean age ranging from 18 to 93 years. There were 353 prognostic models investigated, with area under the curve (AUC) ranging from 0.44 to 0.99. A great proportion of studies (61.5%, 193 out of 314) performed internal or external validation or replication. In 312 (99.4%) studies, prognostic models were reported to be at high risk of bias due to uncertainties and challenges surrounding methodological rigor, sampling, handling of missing data, failure to deal with overfitting and heterogeneous definitions of COVID-19 and severity outcomes. While several clinical prognostic models for COVID-19 have been described in the literature, they are limited in generalizability and/or applicability due to deficiencies in addressing fundamental statistical and methodological concerns. Future large, multi-centric and well-designed prognostic prospective studies are needed to clarify remaining uncertainties.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
COVID-19
Prediction models
Mortality
ICU
Systematic review
Biomarkers
Megjelenés:European Journal Of Epidemiology. - 38 : 4 (2023), p. 355-372. -
További szerzők:Llanaj, Erand (1988-) (táplálkozási epidemiológus) Raeisi-Dehkordi, Hamidreza Kastrati, Lum Amiri, Mojgan Meçani, Renald Taneri, Petek Eylul Ochoa, Sergio Alejandro Gómez Raguindin, Peter Francis Wehrli, Faina Khatami, Farnaz Espínola, Octavio Pano Rojas, Lyda Z. de Mortanges, Aurélie Pahud Macharia-Nimietz, Eric Francis Alijla, Fadi Minder, Beatrice Leichtle, Alexander B. Lüthi, Nora Ehrhard, Simone Que, Yok-Ai Fernandes, Laurenz Kopp Hautz, Wolf E. Muka, Taulant
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM105439
035-os BibID:(cikkazonosító)1940 (WoS)000902645500001 (Scopus)85144728705
Első szerző:Llanaj, Erand (táplálkozási epidemiológus)
Cím:Buckwheat and Cardiometabolic Health : a Systematic Review and Meta-Analysis / Llanaj Erand, Ahanchi Noushin Sadat, Dizdari Helga, Taneri Petek Eylul, Niehot Christa D., Wehrli Faina, Khatami Farnaz, Raeisi-Dehkordi Hamidreza, Kastrati Lum, Bano Arjola, Glisic Marija, Muka Taulant
Dátum:2022
ISSN:2075-4426
Megjegyzések:Buckwheat (BW) is suggested to have beneficial effects, but evidence on how it affects cardiometabolic health (CMH) is not yet established. We aimed to assess the effects of BW and/or its related bioactive compounds on cardiovascular disease (CVD) risk markers in adults. Five databases were searched for eligible studies. Observational prospective studies, nonrandomized or randomized trials were considered if they assessed BW, rutin or quercetin-3-glucoside intake and CVD risk markers. We adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for reporting. We selected 16 human studies based on 831 subjects with mild metabolic disturbances, such as hypercholesterolemia, diabetes and/or overweight. Eight studies, investigating primarily grain components, were included in the meta-analyses (n = 464). High study heterogeneity was present across most of our analyses. Weighted mean difference (WMD) for subjects receiving BW supplementation, compared to controls, were - 0.14 mmol/L (95% CI: -0.30; 0.02) for total cholesterol (TC), -0.03 mmol/L (95% CI: -0.22; 0.16) for LDL cholesterol, -0.14 kg (95% CI: -1.50; 1.22) for body weight, -0.04 mmol/L (95% CI: - 0.09;0.02) for HDL cholesterol, -0.02 mmol/L (95% CI: -0.15; 0.11) for triglycerides and -0.18 mmol/L (95% CI: -0.36; 0.003) for glucose. Most of the studies (66.7%) had concerns of risk of bias. Studies investigating other CVD markers were scarce and with inconsistent findings, where available. Evidence on how BW affects CMH is limited. However, the available literature indicates that BW supplementation in mild dyslipidaemia and type 2 diabetes may provide some benefit in lowering TC and glucose, albeit non-significant. Our work highlights the need for more rigorous trials, with better methodological rigor to clarify remaining uncertainties on potential effects of BW on CMH and its utility in clinical nutrition practice.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Personalized Medicine. - 12 : 12 (2022), p. 1-19. -
További szerzők:Ahanchi, Noushin Sadat Dizdari, Helga Taneri, Petek Eylul Niehot, Christa D. Wehrli, Faina Khatami, Farnaz Raeisi-Dehkordi, Hamidreza Kastrati, Lum Bano, Arjola Glisic, Marija Muka, Taulant
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM102779
035-os BibID:(cikkazonosító)4084 (WOS)000833249800001 (Scopus)85136362336
Első szerző:Llanaj, Erand (táplálkozási epidemiológus)
Cím:Misleading Meta-Analyses during COVID-19 Pandemic : examples of Methodological Biases in Evidence Synthesis / Erand Llanaj, Taulant Muka
Dátum:2022
ISSN:2077-0383
Megjegyzések:Not all evidence is equal. Evidence-based public health and medicine emanate from the principle that there is a hierarchy of evidence, with systematic reviews and meta-analyses (SRMAs) being at the top, as the highest level of evidence. Despite this, it is common in literature to find SRMAs with methodological issues that can distort the results and can thus have serious public health or clinical implications. During the Coronavirus Disease 2019 (COVID-19) pandemic, the importance of evidence and the way in which evidence was produced was stress tested and revealed a wide array of methodological biases that might have led to misleading conclusions and recommendations. We provide a critical examination of methodological biases in selected SRMAs on COVID-19, which have been widely used to guide or justify some pharmaceutical and nonpharmaceutical interventions with high public health and clinical significance, such as mask wearing, asymptomatic transmission, and ivermectin. Through these selected examples, we highlight the need to address biases related to the methodological quality and relevance of study designs and effect size computations and considerations for critical appraisal of available data in the evidence synthesis process for better quality evidence. Such considerations help researchers and decision makers avoid misleading conclusions, while encouraging the provision of the best policy recommendations for individual and public health.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
evidence synthesis
meta-analyses
COVID-19
public health
Megjelenés:Journal of Clinical Medicine. - 11 : 14 (2022), p. 1-7. -
További szerzők:Muka, Taulant
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM099767
035-os BibID:(WoS)000737102800002 (Scopus)85122267234
Első szerző:Llanaj, Erand (táplálkozási epidemiológus)
Cím:Effect of oat supplementation interventions on cardiovascular disease risk markers : a systematic review and meta-analysis of randomized controlled trials / Llanaj Erand, Dejanovic Gordana M., Valido Ezra, Bano Arjola, Gamba Magda, Kastrati Lum, Minder Beatrice, Stojic Stevan, Voortman Trudy, Marques-Vidal Pedro, Stoyanov Jivko, Metzger Brandon, Glisic Marija, Kern Hua, Muka Taulant
Dátum:2022
ISSN:1436-6207
Megjegyzések:Purpose Oat supplementation interventions (OSIs) may have a beneficial effect on cardiovascular disease (CVD) risk. However, dietary background can modulate such effect. This systematic review assesses the effects of OSIs on CVD risk markers among adults, accounting for different dietary backgrounds or control arms. Methods We included randomized clinical trials (RCTs) that assessed the effect of oat, oat beta-glucan-rich extracts or avenanthramides on CVD risk markers. Results Seventy-four RCTs, including 4937 predominantly hypercholesterolemic, obese subjects, with mild metabolic disturbances, were included in the systematic review. Of these, 59 RCTs contributed to the meta-analyses. Subjects receiving an OSI, compared to control arms without oats, had improved levels of total cholesterol (TC) [weighted mean difference and (95% CI) - 0.42 mmol/L, (- 0.61; - 0.22)], LDL cholesterol [- 0.29 mmol/L, (- 0.37; - 0.20)], glucose [- 0.25 nmol/L, (- 0.36; - 0.14)], body mass index [- 0.13 kg/m(2), (- 0.26; - 0.01)], weight [- 0.94 kg, (- 1.84: - 0.05)], and waist circumference [- 1.06 cm, (- 1.85; - 0.27)]. RCTs on inflammation and/or oxidative stress markers were scarce and with inconsistent findings. RCTs comparing an OSI to heterogeneous interventions (e.g., wheat, eggs, rice, etc.), showed lowered levels of glycated haemoglobin, diastolic blood pressure, HDL cholesterol and apolipoprotein B. The majority of included RCTs (81.1%) had some concerns for risk of bias. Conclusion Dietary OSIs resulted in lowered levels of blood lipids and improvements in anthropometric parameters among participants with predominantly mild metabolic disturbances, regardless of dietary background or control. Further high-quality trials are warranted to establish the role of OSIs on blood pressure, glucose homeostasis and inflammation markers.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:European Journal Of Nutrition. - 61 : 4 (2022), p. 1749-1778. -
További szerzők:Dejanovic, Gordana M. Valido, Ezra Bano, Arjola Gamba, Magda Kastrati, Lum Minder, Beatrice Stojic, Stevan Voortman, Trudy Marques-Vidal, Pedro Stoyanov, Jivko Metzger, Brandon Glisic, Marija Kern, Hua Muka, Taulant
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM087474
035-os BibID:(WoS)000561986500001 (Scopus)85089701413
Első szerző:Taneri, Petek Eylul
Cím:Anemia and iron metabolism in COVID-19 : a systematic review and meta-analysis / Petek Eylul Taneri, Sergio Alejandro Gómez-Ochoa, Erand Llanaj, Peter Francis Raguindin, Lyda Z. Rojas, Zayne Milena Roa-Díaz, Dante Salvador Jr., Dion Groothof, Beatrice Minder, Doris Kopp-Heim, Wolf E. Hautz, Michele F. Eisenga, Oscar H. Franco, Marija Glisic, Taulant Muka
Dátum:2020
ISSN:0393-2990
Megjegyzések:Iron metabolism and anemia may play an important role in multiple organ dysfunction syndrome in Coronavirus disease 2019 (COVID-19). We conducted a systematic review and meta-analysis to evaluate biomarkers of anemia and iron metabolism (hemoglobin, ferritin, transferrin, soluble transferrin receptor, hepcidin, haptoglobin, unsaturated iron-binding capacity, erythropoietin, free erythrocyte protoporphyrine, and erythrocyte indices) in patients diagnosed with COVID-19, and explored their prognostic value. Six bibliographic databases were searched up to August 3rd 2020. We included 189 unique studies, with data from 57,563 COVID-19 patients. Pooled mean hemoglobin and ferritin levels in COVID-19 patients across all ages were 129.7 g/L (95% Confidence Interval (CI), 128.51; 130.88) and 777.33 ng/mL (95% CI, 701.33; 852.77), respectively. Hemoglobin levels were lower with older age, higher percentage of subjects with diabetes, hypertension and overall comorbidities, and admitted to intensive care. Ferritin level increased with older age, increasing proportion of hypertensive study participants, and increasing proportion of mortality. Compared to moderate cases, severe COVID-19 cases had lower hemoglobin [weighted mean difference (WMD), - 4.08 g/L (95% CI - 5.12; - 3.05)] and red blood cell count [WMD, - 0.16 x 10(12)/L (95% CI - 0.31; - 0.014)], and higher ferritin [WMD, - 473.25 ng/mL (95% CI 382.52; 563.98)] and red cell distribution width [WMD, 1.82% (95% CI 0.10; 3.55)]. A significant difference in mean ferritin levels of 606.37 ng/mL (95% CI 461.86; 750.88) was found between survivors and non-survivors, but not in hemoglobin levels. Future studies should explore the impact of iron metabolism and anemia in the pathophysiology, prognosis, and treatment of COVID-19.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
COVID-19
SARS-CoV-2
Megjelenés:European Journal Of Epidemiology. - 35 : 8 (2020), p. 763-773. -
További szerzők:Gómez-Ochoa, Sergio Alejandro Llanaj, Erand (1988-) (táplálkozási epidemiológus) Raguindin, Peter Francis Rojas, Lyda Z. Roa-Díaz, Zayne Milena Salvador, Dante Groothof, Dion Minder, Beatrice Kopp-Heim, Doris Hautz, Wolf E. Eisenga, Michele F. Franco, Oscar H. Glisic, Marija Muka, Taulant
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM106086
035-os BibID:(cikkazonosító)1 (WOS)000908911400001 (Scopus)85145920793
Első szerző:Valido, Ezra
Cím:Systematic Review of Human and Animal Evidence on the Role of Buckwheat Consumption on Gastrointestinal Health / Valido Ezra, Stoyanov Jivko, Gorreja Frida, Stojic Stevan, Niehot Christa, Kiefte-de Jong Jessica, Llanaj Erand, Muka Taulant, Glisic Marija
Dátum:2023
ISSN:2072-6643
Megjegyzések:Background: Buckwheat is a commonly cultivated crop with growing evidence that it is beneficial to gastrointestinal (GI) health. This systematic review summarizes the role of buckwheat in modifying GI health outcomes and microbiomes. Methods: Four medical databases and Google Scholar were systematically searched. Clinical trials, observational studies, animal in vivo, and in vitro studies with human and animal GI-derived samples were included. Results: There were 32 studies (one randomized controlled trial [RCT], one non-randomized trial, 3 observational, 9 in vitro, and 18 animal in vivo studies) included. In preclinical studies, buckwheat extracts were observed to have cytotoxic potential against human-derived GI cancer cell lines. Animals fed with buckwheat had lower GI mucosal inflammation, higher alpha diversity in the GI microbiome, and higher levels of fecal short-chain fatty acids. Human evidence studies and clinical trials were limited and predominantly of moderate risk of bias. The majority of in vitro studies with GI-derived samples and in vivo studies were reliable without restrictions in study design. Conclusion: In vivo and in vitro studies show that buckwheat may have potential GI benefits due to its anti-oxidant and anti-inflammatory potential; however, human evidence remains limited, and its impact on health in humans remains to be elucidated in future trials.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
buckwheat
Tartary buckwheat
gastrointestinal symptoms
microbiome
Megjelenés:Nutrients. - 15 : 1 (2023), p. 1-18. -
További szerzők:Stoyanov, Jivko Gorreja, Frida Stojic, Stevan Niehot, Christa D. Kiefte-de Jong, Jessica Llanaj, Erand (1988-) (táplálkozási epidemiológus) Muka, Taulant Glisic, Marija
Pályázati támogatás:NA
Other
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

7.

001-es BibID:BIBFORM115513
035-os BibID:(WoS)001100140000001 (Scopus)85174411475
Első szerző:Vincze Ferenc (táplákozástudományi szakember, epidemiológus)
Cím:Eating out intensity, ultra-processed foods and body mass index among Albanian youth / Ferenc Vincze, Taulant Muka, Fabian Eichelmann, Erand Llanaj
Dátum:2023
ISSN:1368-9800
Megjegyzések:Objective: Ultra-processed foods (UPF) and eating out of home (OH) are changing nutrition, particularly among youth in constrained settings. We aimed to assess the role of eating OH intensity on the associations of UPF and unprocessed or minimally processed foods (UMPF) with BMI among Albanian youth. Design: Cross-sectional. Setting: Albania, a south-eastern European country. Participants: 281 youth, predominantly females. Methods: UPF and UMPF were defined based on NOVA, while eating OH intensity based on energy percentage from OH foods. Multivariable models tested associations of UPF and UMPF with BMI stratified by eating OH intensity, controlled for relevant covariates including diet quality, portion size and costs. Results: The respondents age ranged between 18 and 23 years with a female predominance (87.5 %). Mean energy from UPF and UMPF was 846 (sd: 573.0) and 802.9 (422.5) kcals, respectively. Among substantial at home eaters UPF intake was not associated (beta = -0.07, 95 % CI (-0.13, 0.267)) with BMI; however, UMPF negatively associated with BMI (beta = -0.24, 95 % CI (-0.43, -0.06)). Among those defined as substantial OH eaters, UPF (beta = 0.24, 95 % CI (0.08, 0.40)) and UMPF (beta = 0.18, 95 % CI (0.04, 0.33)) were positively associated with BMI. Conclusions: Our findings provide evidence for the hypothesis that eating OH plays an important role in the association of UPF and UMPF with BMI in youth. While causality cannot be established due to cross-sectional design, to the best of our knowledge, we provide the first assessment of UPF and UMPF intake in a south-eastern European setting, while highlighting the need for establishing and integrating youth nutrition into national nutritional surveillance systems for key dietary risk factors in Albania.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
youth
BMI
eating out of home
diet quality
Megjelenés:Public Health Nutrition. - 26 : 12 (2023), p. 2953-2962. -
További szerzők:Muka, Taulant Eichelmann, Fabian Llanaj, Erand (1988-) (táplálkozási epidemiológus)
Pályázati támogatás:DFG-German Research Foundation
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1