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001-es BibID:BIBFORM095573
035-os BibID:(cikkazonosító)109594 (WoS)000688508300032 (Scopus)85113379671 (PubMed)34433068
Első szerző:Dautan, Daniel
Cím:Modulation of motor behavior by the mesencephalic locomotor region / Daniel Dautan, Adrienn Kovács, Tsogbadrakh Bayasgalan, Miguel Diaz, Balazs Pal, Juan Mena-Segovia
Dátum:2021
ISSN:2211-1247
Megjegyzések:The mesencephalic locomotor region (MLR) is a functionally-defined area located in the midbrain that serves as an interface between higher-order motor systems (e.g. basal ganglia and cortex) and lower motor neurons (brainstem and spinal cord). The excitatory module of the MLR is composed of the pedunculopontine nucleus (PPN) and the cuneiform nucleus (CnF) and their activation has been proposed to elicit different modalities of movement, but whether differences in connectivity and physiological properties explain their contributions to motor activity is not known. Here we report that CnF-glutamatergic neurons are functionally homogeneous and have short-range axonal projections, whereas PPN-glutamatergic neurons are heterogeneous and maintain long-range connections with other motor circuits, most notably the basal ganglia. Optogenetic activation of CnF-neurons produced short-lasting muscle activation and fast-onset, involuntary motor activity, whereas activation of PPN-neurons produced long-lasting muscle activation, decreased locomotion and disrupted gait. Our results thus reveal a differential contribution to motor behavior in the structures that compose the MLR.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Cell Reports. - 36 : 8 (2021), p. 109594. -
További szerzők:Kovács Adrienn (1989-) (molekuláris biológus) Bayasgalan, Tsogbadrakh (1983-) (Általános orvos) Diaz-Acevedo, Miguel A. Pál Balázs (1975-) (élettanász) Mena-Segovia, Juan
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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