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001-es BibID:	BIBFORM092154
035-os BibID:	(scopus)85102963479 (wos)000631390100001
Első szerző:	Bekele, Bayu Begashaw (PhD hallgató)
Cím:	Is Prescription Nonredemption a Source of Poor Health Among the Roma? Cross-Sectional Analysis of Drug Consumption Data From the National Health Insurance Fund of Hungary / Bayu Begashaw Bekele, Nouh Harsha, László Korösi, Ferenc Vincze, Árpád Czifra, Róza Ádány, János Sándor
Dátum:	2021
ISSN:	1663-9812
Megjegyzések:	Background: The health status of the Roma is inferior to that of the general population. The causes of poor health among this population are still ambiguous, but they include low utilization of healthcare services. Our study aimed to investigate prescription redemptions in segregated Roma colonies (SRC) where the most disadvantaged quartile of Roma people are living. Methods: A cross-sectional study was carried out with data obtained from the National Institute of Health Insurance Fund Management in the settlements belonging to the study area of the "Public Health-Focused Model Program for Organizing Primary Care Services." The study included 4,943 residents of SRC and 62,074 residents of the complementary area (CA) of the settlements where SRC were located. Crude and age- and sexstandardized redemption ratios for SRC and CA were calculated for each Anatomic Therapeutic Chemical (ATC) group and for the total practice by ATC group. Standardized relative redemptions (RR) with 95% confidence intervals were calculated for SRC, with CA as a reference. Results: The crude redemption ratios were 73.13% in the SRC and 71.15% in the CA. RRs were higher in the SRC than in the CA for cardiovascular, musculoskeletal system, and alimentary tract and metabolism drugs (11.5, 3.7, and 3.5%, respectively). In contrast, RRs were lower in the SRC than in the CA for anti-infective agents (22.9%) due to the poor redemption of medicines prescribed for children or young adults. Despite the overall modest differences in redemption ratios, some ATC groups showed remarkable differences. Those include cardiovascular, alimentary and musculoskeletal drugs. Conclusion: Redemption of prescriptions was significantly higher among Roma people living in SRC than among those living in CA. The better redemption of cardiovascular and alimentary tract drugs was mainly responsible for this effect. These findings contradict the stereotype that the Roma do not use health services properly and that prescription nonredemption is responsible for their poor health.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk prescription non-redemption Roma people cardiovascular drugs alimentary tract drugs anti-infective agents
Megjelenés:	Frontiers in Pharmacology. - 12 (2021), p. 1-9. -
További szerzők:	Harsha, Nouh (1979-) Kőrösi László Vincze Ferenc (1987-) (táplákozástudományi szakember, epidemiológus) Czifra Árpád (1983-) (belgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Sándor János (1966-) (orvos-epidemiológus)
Pályázati támogatás:	Swiss Contribution Program (SH/8/1) Egyéb GINOP-2.3.2-15-2016-00005 Egyéb SHE-15324-002/2018 Egyéb SHE-124219 Egyéb
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001-es BibID:	BIBFORM082685
Első szerző:	Pikó Péter (biológus)
Cím:	The Effect of Haplotypes in the CETP and LIPC Genes on the Triglycerides to HDL-C Ratio and Its Components in the Roma and Hungarian General Populations / Peter Piko, Szilvia Fiatal, Nardos Abebe Werissa, Bayu Begashaw Bekele, Gabor Racz, Zsigmond Kosa, Janos Sandor, Roza Adany
Dátum:	2020
ISSN:	2073-4425 2073-4425
Megjegyzések:	Background: The triglycerides (TG) to high-density lipoprotein (HDL)-cholesterol (HDLC) ratio (TG/HDL-C) is a well-known predictor for cardiovascular diseases (CVDs) with great heritability background. The cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) gene affect TG/HDL-C ratio. This study aims to explore the association between haplotypes (H) in CETP (based on 5 single nucleotide polymorphisms (SNPs)) and LIPC (based on 6 SNPs) genes and the TG/HDL-C ratio and its components, among Roma and Hungarian general populations. Methods: The prevalence of haplotypes and their effect on HDL-C, TG and TG/HDL-C ratio were calculated in both populations and compared. Results: Ten haplotypes in CETP and 6 in LIPC gene were identified. Three haplotypes in CETP and 3 in LIPC have significant effect on HDL-C level, whereas two in CETP and 3 in LIPC on TG level. The H6 in CETP (? = 0.52, p = 0.015; odds ratio (OR) = 1.87, p = 0.009) and H5 in LIPC (? = 0.56, p < 0.001; OR = 1.51, p = 0.002) have a significant increasing effect on TG/HDL-C ratio and have shown higher prevalence among the Roma, as compared to Hungarian general population. The H2 in the CETP gene has a decreasing effect on the TG/HDL-C ratio (OR = 0.58, p = 0.019) and is significantly less frequent among the Roma. Conclusions: Accumulation of harmful haplotypes in CETP and LIPC genes might have a role in the elevated TG/HDL-C ratio in the Roma population, which contributes to a higher risk in the development of cardiovascular diseases.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk single nucleotide polymorphism triglyceride high-density lipoprotein cholesterol TG/HDL-C ratio Roma Hungarian general CETP LIPC haplotype cardiometabolic risk
Megjelenés:	Genes. - 11 : 56 (2020), p. 1-13. -
További szerzők:	Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Werissa, Nardos Abebe (1985-) Bekele, Bayu Begashaw (1988-) (PhD hallgató) Rácz Gábor (1982-) (orvos, környezetegészségügyi szakember) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	TÁMOP 4.2.1. B-09/1/KONV-2010-0007 Egyéb TÁMOP 4.2.2. A-11/1/KONV-2012-0031 Egyéb GINOP-2.3.2-15-2016-00005 Egyéb MTA11010 Egyéb TK2016- 78 Egyéb
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