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001-es BibID:	BIBFORM115804
035-os BibID:	(cikkazonosító)2970 (WoS)001120943600001 (Scopus)85178374983
Első szerző:	Al-Smadi, Mohammad Walid
Cím:	A Microsurgical Arteriovenous Malformation Model on Saphenous Vessels in the Rat / Mohammad Walid Al-Smadi, Laszlo Adam Fazekas, Siran Aslan, Brigitta Bernat, Anas Beqain, Mustafa Qais Muhsin Al-Khafaji, Daniel Priksz, Brigitta Orlik, Norbert Nemeth
Dátum:	2023
ISSN:	2227-9059
Megjegyzések:	Arteriovenous malformation (AVM) is an anomaly of blood vessel formation. Numerous models have been established to understand the nature of AVM. These models have limitations in terms of the diameter of the vessels used and the impact on the circulatory system. Our goal was to establish an AVM model that does not cause prompt and significant hemodynamic and cardiac alterations but is feasible for follow-up of the AVM's progression. Sixteen female rats were randomly divided into sham-operated and AVM groups. In the AVM group, the saphenous vein and artery were interconnected using microsurgical techniques. The animals were followed up for 12 weeks. Anastomosis patency and the structural and hemodynamic changes of the heart were monitored. The hearts and vessels were histologically analyzed. During the follow-up period, shunts remained unobstructed. Systolic, diastolic, mean arterial pressure, and heart rate values slightly and non-significantly decreased in the AVM group. Echocardiogram results indicated minor systolic function impact, with slight and insignificant changes in aortic pressure and blood velocity, and minimal left ventricular wall enlargement. The small-caliber saphenous AVM model does not cause acute hemodynamic changes. Moderate but progressive alterations and venous dilatation confirmed AVM-like features. The model seems to be suitable for studying further the progression, enlargement, or destabilization of AVM.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Biomedicines. - 11 : 11 (2023), p. 1-14. -
További szerzők:	Fazekas László Aslan, Siran Bernát Brigitta (1997-) (farmakológus) Beqain, Anas Al-Khafaji, Mustafa Qais Muhsin Priksz Dániel (1989-) (farmakológus) Orlik Brigitta Németh Norbert (1975-) (kutatóorvos)
Pályázati támogatás:	NKFI-1 "OTKA" K-139184 OTKA UNKP-22-3-I-DE-344 UNKP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM101455
035-os BibID:	(cikkazonosító)970 (WoS)000786981800001 (Scopus)85128843077
Első szerző:	Szegeczki Vince
Cím:	Endometrium as Control of Endometriosis in Experimental Research : assessment of Sample Suitability / Szegeczki Vince, Fazekas László, Kulcsár Máté, Reglodi Dora, Török Péter, Orlik Brigitta, Lagana Antonio Simone, Jakab Attila, Juhasz Tamas
Dátum:	2022
ISSN:	2075-4418
Megjegyzések:	Endometriosis is a chronic gynecological disease that causes numerous severe symptoms in affected women. Revealing alterations of the molecular processes in ectopic endometrial tissue is the current policy for understanding the pathomechanisms and discovering potential novel thera- peutic targets. Examining molecular processes of eutopic endometrium is likely to be a convenient method to compare it with the molecular alterations observed in ectopic tissues. The aim of the present study was to determine what proportion of the surgically resected eutopic endometrial samples is suitable for further experiments so that these can be comparable with endometriosis. Final hospital reports and histopathology reports of a 3-year-long period (1162 cases) were ana- lysed. The application of a retrospective screening method promoted the categorization of these cases, and quantification of the categorized cases was accomplished. In addition, results obtained from cultured endometrium samples were also detailed. Only a small number of the harvested en- dometrial samples was suitable for further molecular analysis, while preoperative screening proto- col could enlarge this fraction. Applying clinical and histopathological selection and exclusion cri- teria for tissue screening and histopathological examination of samples could ensure the compara- bility of healthy endometrium with endometriosis. The present study could be useful for research- ers who intend to perform molecular experiments to compare endometriosis with the physiological processes of the endometrium.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk endometrium curettage hysteroscopy endometrial sampling in vitro endometrial culturing
Megjelenés:	Diagnostics. - 12 : 4 (2022), p. 1-17. -
További szerzők:	Fazekas László Kulcsár Máté Reglődi Dóra (Idegtudományok) Török Péter (1975-) (szülész-nőgyógyász) Orlik Brigitta Laganà, Antonio Simone Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus) Juhász Tamás (1976-) (biológus, orvosbiológus)
Pályázati támogatás:	ÚNKP-17-2 Egyéb ÚNKP-19-3 Egyéb ÚNKP-20-3-II Egyéb EFOP-3.6.3-VEKOP-16-2017-00009 EFOP NKFIHK139396 Egyéb MTA-TKI 14016 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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