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001-es BibID:	BIBFORM116678
035-os BibID:	(Scopus)85170062413 (WoS)001063954400001
Első szerző:	Wéber András
Cím:	Gains in life expectancy from decreasing cardiovascular disease and cancer mortality - an analysis of 28 European countries 1995-2019 / András Wéber, Mathieu Laversanne, Péter Nagy, István Kenessey, Isabelle Soerjomataram, Freddie Bray
Dátum:	2023
ISSN:	0393-2990
Megjegyzések:	Background: Life expectancy (LE) is an indicator of societal progress among rapidly aging populations. In recent decades, the displacement of deaths from cardiovascular disease (CVD) and cancer have been key drivers in further extending LE on the continent, though improvements vary markedly by country, sex, and over time. This study provides a comparative overview of the age-specific contributions of CVD and cancer to increasing LE in the 27 European Union member states, plus the U.K. Methods: Cause-by-age decompositions of national changes in LE were conducted for the years 1995?1999 and 2015?2019 based on the standard approach of multiple decrement life tables to quantify the relative impact over time. The contributions of CVD and cancer mortality changes to differences in LE were computed by sex and age for each of the 28 countries. We examine the difference between the member states before 2004 ("founding countries") and those which accessed the EU after 2004 ("A10 countries"). Results: Among men, declines in CVD mortality in the founding countries of the EU were larger contributors to increasing LE over the last decades than malignant neoplasms: 2.26 years were gained by CVD declines versus 1.07 years for cancer, with 2.23 and 0.84 years gained in A10 countries, respectively. Among women in founding countries, 1.81 and 0.54 additional life years were attributable to CVD and cancer mortality declines, respectively, while in A10 countries, the corresponding values were 2.33 and 0.37 years. Lung and stomach cancer in men, and breast cancer in women were key drivers of gains in LE due to cancer overall, though rising mortality rates from lung cancer diminished the potential impact of increasing female LE in both EU founding (e.g., France, Spain, and Sweden) and A10 countries (e.g., Croatia, Hungary, and Slovenia), notably among cohorts aged 55?70 years. Over the 25 years, the LE gap between the two sets of countries narrowed from 6.22 to 5.59 years in men, and from 4.03 to 3.12 years for women, with diminishing female mortality from CVD as a determinative contributor. Conclusion: This study underscores the continued existence of an East-West divide in life expectancy across the EU27 + 1, evident on benchmarking the founding vs. A10 countries. In EU founding countries, continuous economic growth alongside improved health care, health promotion and protection policies have contributed to steady declines in mortality from chronic diseases, leading to increases in life expectancy. In contrast, less favourable mortality trends in the EU A10 countries indicate greater economic and health care challenges, and a failure to implement effective health policies.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cancer causes of death Cardiovascular mortality Decomposition Geographical visualization Life expectancy
Megjelenés:	European Journal Of Epidemiology. - 38 : 11 (2023), p. 1141-1152. -
További szerzők:	Laversanne, Mathieu Nagy Péter (1976-) (vegyész) Kenessey István Soerjomataram, Isabelle Bray, Freddie
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001-es BibID:	BIBFORM113488
035-os BibID:	(cikkazonosító)e065303 (Scopus)85158910226 (WoS)001001381400001
Első szerző:	Wéber András
Cím:	Lung cancer mortality in the wake of the changing smoking epidemic: a descriptive study of the global burden in 2020 and 2040 / András Wéber, Eileen Morgan, Jerome Vignat, Mathieu Laversanne, Margherita Pizzato, Harriet Rumgay, Deependra Singh, Péter Nagy, István Kenessey, Isabelle Soerjomataram, Freddie Bray
Dátum:	2023
ISSN:	2044-6055
Megjegyzések:	Objectives - Lung cancer (LC) is the leading cause of cancer death in 2020, responsible for almost one in five (18.0%) deaths. This paper provides an overview of the descriptive epidemiology of LC based on national mortality estimates for 2020 from the International Agency for Research on Cancer (IARC), and in the context of recent tobacco control policies. Design and setting - For this descriptive study, age-standardised mortality rates per 100?000 person-years of LC for 185 countries by sex were obtained from the GLOBOCAN 2020 database and stratified by Human Development Index (HDI). LC deaths were projected to 2040 based on demographic changes alongside scenarios of annually increasing, stable or decreasing rates from the baseline year of 2020. Results - LC mortality rates exhibited marked variations by geography and sex. Low HDI countries, many of them within sub-Saharan Africa, tend to have low levels of mortality and an upward trend in LC deaths is predicted for both sexes until 2040 according to demographic projections, irrespective of trends in rates. In very high HDI countries, including Europe, Northern America and Australia/New Zealand, there are broadly decreasing trends in men whereas in women, rates are still increasing or reaching a plateau. Conclusion - The current and future burden of LC in a country or region largely depends on the present trajectory of the smoking epidemic in its constituent populations, with distinct gender differences in smoking patterns, both in transitioning and transitioned countries. Further elevations in LC mortality are expected worldwide, raising important social and political questions, especially in low-income and middle-income countries.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	BMJ Open. - 13 : 5 (2023), p. 1-8. -
További szerzők:	Morgan, Eileen Vignat, Jerome Laversanne, Mathieu Pizzato, Margherita Rumgay, Harriet Singh, Deependra Nagy Péter (1976-) (vegyész) Kenessey István Soerjomataram, Isabelle Bray, Freddie
Pályázati támogatás:	TKP2021-EGA-44 Egyéb 2022-2.1.1-NL-2022-00010 Egyéb
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001-es BibID:	BIBFORM111471
Első szerző:	Wéber András
Cím:	A daganatos jelentések minőségbiztosítási visszacsatolása a Nemzeti Rákregiszter adatbázisának elemzésével / Wéber András, Mery Les, Nagy Péter, Kásler Miklós, Polgár Csaba, Bray Freddie, Kenessey István
Dátum:	2021
ISSN:	0025-0244
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Magyar Onkologia. - 65 : Suppl.1. (2021), p. 63-64. -
További szerzők:	Mery, Les Nagy Péter (1976-) (vegyész) Kásler Miklós Polgár Csaba Bray, Freddie Kenessey István
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM111173
035-os BibID:	(cikkazonosító)102306 (WoS)000906318800001 (Scopus)85143853908 (Pubmed)36521336
Első szerző:	Wéber András
Cím:	Evaluation of data quality at the Hungarian National Cancer Registry, 2000-2019 / Andras Wéber, Les Mery, Péter Nagy, Csaba Polgár, Freddie Bray, István Kenessey
Dátum:	2023
ISSN:	1877-7821 1877-783X
Megjegyzések:	Background: The Hungarian National Cancer Registry (HNCR) was legally established as a population-based cancer registry in 1999, and its operation started in 2000 supporting the planning and development of the Hungarian oncology network as well as informing national cancer control policies. Ensuring comparable, ac-curate, and complete data on malignant and in situ neoplasms is critical in determining the applicability of the database. The aim of this study was to perform a comprehensive evaluation of the data quality at the HNCR. Methods: Based on qualitative and semiquantitative methods from current international guidelines, we assess the comparability, completeness, validity, and timeliness of the collected data over the diagnostic period 2000-2019, with a focus on the year 2018. Results: Coding practices and the classification system used at the HNCR are based on the International Classi-fication of Diseases (ICD-10), which differs from the internationally recommended ICD-O. The annual trends in incidence did not indicate major fluctuations, that may have resulted from data collection discrepancies, while comparisons of the mortality-to-incidence ratio (M:I) compared with 1 minus 5-year observed survival indicated some systematic differences requiring further exploration. The age-standardized (European standard) incidence rate per 100 000 measured by the HNCR in 2018 was very high: 647.9 for men and 501.6 for women, 11.6% and 14.6% higher than the International Agency for Research on Cancer (IARC) estimates respectively. Behind the overall differences between the two data sources, we identified that the vast majority were due to ill-defined ICD codes: malignant neoplasm of other and ill-defined sites (C76), and malignant neoplasm without specification of site (C80). Otherwise, there were no major discrepancies by localization. The proportion of morphologically verified cancer cases was 57.8% overall, that of death certificates was 2.3%, and that of unknown primary tumors was 1.4%. Conclusion: Further implementations and interventions are required to ensure that the operations, coding practices, and the classification system used at the national registry are in accordance with international stan-dards, and to increase the completeness and validity of the collected cancer data. In particular, the low morphologically verified proportion questions the overall accuracy of the stated diagnoses within the database. Nevertheless, our examination implies that the data of the HNCR are reasonably comparable, and without doubt fulfill the requirements to support national oncology services and cancer planning. However, most importantly, a review of registry personnel and resource requirements to run the national population-based cancer registry should be an essential part of Hungary's national cancer strategy.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk cancer registry data quality comparability completeness validity timeliness Hungary
Megjelenés:	Cancer Epidemiology. - 82 (2023), p. 1-7. -
További szerzők:	Mery, Les Nagy Péter (1976-) (vegyész) Polgár Csaba Bray, Freddie Kenessey István
Pályázati támogatás:	TKP2020-NKA-26 Egyéb TKP2021-EGA-44 Egyéb 2022-2.1.1-NL-2022-00010 Egyéb IV/4925/2021/EKF Egyéb
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