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001-es BibID:	BIBFORM094564
035-os BibID:	(cikkazonosító)639143 (WoS)000658160400001 (Scopus)85107334089
Első szerző:	Nagy Károly (népegészségügyi felügyelő)
Cím:	Micronucleus Formation Induced by Glyphosate and Glyphosate-Based Herbicides in Human Peripheral White Blood Cells / Károly Nagy, Roba Argaw Tessema, István Szász, Tamara Smeirat, Alaa Al Rajo, Balázs Ádám
Dátum:	2021
ISSN:	2296-2565
Megjegyzések:	Glyphosate is the most commonly used herbicide around the world, which led to its accumulation in the environment and consequent ubiquitous human exposure. Glyphosate is marketed in numerous glyphosate-based herbicide formulations (GBHs) that include co-formulants to enhance herbicidal effect of the active ingredient, but are declared as inert substances. However, these other ingredients can have biologic activity on their own and may interact with the glyphosate in synergistic toxicity. In this study, we focused to compare the cytogenetic effect of the active ingredient glyphosate and three marketed GBHs (Roundup Mega, Fozat 480, and Glyfos) by investigating cytotoxicity with fluorescent co-labeling and WST-1 cell viability assay as well as genotoxicity with cytokinesis block micronucleus assay in isolated human mononuclear white blood cells. Glyphosate had no notable cytotoxic activity over the tested concentration range (0?10,000 ?M), whereas all the selected GBHs induced significant cell death from 1,000 ?M regardless of metabolic activation (S9). Micronucleus (MN) formation induced by glyphosate and its formulations at sub-cytotoxic concentrations (0?100 ?M) exhibited a diverse pattern. Glyphosate caused statistically significant increase of MN frequency at the highest concentration (100 ?M) after 20-h exposure. Contrarily, Roundup Mega exerted a significant genotoxic effect at 100 ?M both after 4- and 20-h exposures; moreover, Glyfos and Fozat 480 also resulted in a statistically significant increase of MN frequency from the concentration of 10 ?M after 4-h and 20-h treatment, respectively. The presence of S9 had no effect on MN formation induced by either glyphosate or GBHs. The differences observed in the cytotoxic and genotoxic pattern between the active principle and formulations confirm the previous concept that the presence of co-formulants in the formulations or the interaction of them with the active ingredient is responsible for the increased toxicity of herbicide products, and draw attention to the fact that GBHs are still currently in use, the toxicity of which rivals that of POEA-containing formulations (e.g., Glyfos) already banned in Europe. Hence, it is advisable to subject them to further comprehensive toxicological screening to assess the true health risks of exposed individuals, and to reconsider their free availability to any users.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Public Health. - 9 (2021), p. 1-12. -
További szerzők:	Tessema, Roba Argaw (1979-) Szász István (1985-) (Ph.D hallgató) Smeirat Tamara Al Rajo, Alaa Ádám Balázs (1973-) (megelőző orvostan és népegészségtan szakorvos)
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001-es BibID:	BIBFORM085659
035-os BibID:	(cikkazonosító)108851 (WoS)000502685500020 (Scopus)85074159335
Első szerző:	Nagy Károly (népegészségügyi felügyelő)
Cím:	Comparative cyto- and genotoxicity assessment of glyphosate and glyphosate-based herbicides in human peripheral white blood cells / Nagy Károly, Tessema Roba Argaw, Budnik Lygia Therese, Ádám Balázs
Dátum:	2019
ISSN:	0013-9351
Megjegyzések:	Glyphosate is the most heavily applied active compound of agricultural pesticides. It is solely used in more than 750 different glyphosate-based herbicide formulations (GBHs) that also contain other substances, mostly presumed as inert by regulatory agencies. The toxicity of formulations is currently assessed substance by substance, neglecting possible combined effects in mixtures and many of the findings regarding the toxic effects of glyphosate and GBHs to human cells are inconsistent. This is the first study to investigate and compare the cyto- and genotoxic potential of the active ingredient glyphosate and GBHs in human mononuclear white blood (HMWB) cells. HMWB cells were treated for 4 h at 37 ?C with increasing concentrations (1?1000 ?M) of glyphosate alone and in three GBHs (Roundup Mega, Fozat 480 and Glyfos) to test cytotoxic effect with fluorescent colabelling and genotoxic effect with comet assay. In addition, each concentration was tested with and without metabolic activation using human liver S9 fraction. We found that glyphosate alone does not induce significant cytotoxicity and genotoxicity over the tested concentration range. Contrarily, GBHs induced statistically significant cell death from 250 ?M (Roundup Mega and Glyfos) and 500 ?M (Fozat 480), as well as statistically significant increase of DNA damage from 500 ?M (Roundup Mega and Glyfos) and 750 ?M (Fozat 480); however, the latter observation may not be explained by direct DNA injuries, rather due to the high level of cell death (> 70%) exerted by the formulations. Metabolic activation significantly increased the DNA damage levels induced by Glyfos, but not of the other GBHs and of glyphosate. The differences observed in the toxic pattern of formulations and the active principle may be attributed to the higher cytotoxic activity of other ingredients in the formulations or to the interaction of them with the active ingredient glyphosate. Hence, further investigation of formulations is crucial for assessing the true health risks of occupational and environmental exposures.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Environmental Research. - 179 (2019), p. 1-7. -
További szerzők:	Tessema, Roba Argaw (1979-) Budnik, Lygia Therese Ádám Balázs (1973-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	Stipendium Hungaricum Programme of the Tempus Public Foundation Egyéb
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001-es BibID:	BIBFORM105767
035-os BibID:	(cikkazonosító)1017189 (WoS)000898359000001 (Scopus)85144027112
Első szerző:	Tessema, Roba Argaw
Cím:	Occupational and environmental pesticide exposure and associated health risks among pesticide applicators and non-applicator residents in rural Ethiopia / Roba Argaw Tessema, Károly Nagy, Balázs Ádám
Dátum:	2022
ISSN:	2296-2565
Megjegyzések:	Intensive pesticide use increased concern about the potential acute and chronic health eects of pesticides in general and among applicators in particular. This study aims to explore occupational and environmental pesticide exposure and health risks among pesticide applicators and residents. A community-based cross-sectional study was conducted involving 1,073 individuals. We examined the health eects potentially attributable to pesticide exposure using regression to estimate prevalence ratios (PR). A higher proportion of good knowledge of pesticides [75 vs. 14%; APR = 1.542 (1.358?1.752), p < 0.001] and a higher mean score of perceived health risk of pesticide use [4.21 vs. 3.90; APR = 1.079 (1.004?1.159), p < 0.05] were observed among applicators than residents. A significantly higher proportion of applicators experienced health eects presumably related to pesticide exposure among themselves (36%) than residents (16%), and a higher proportion of them used prescribed drugs in the past 12 months [51 vs. 32%; APR = 1.140 (1.003?1.295), p < 0.05]. Skin irritation, shortness of breath, cough, and dizziness were more likely reported by applicators than residents. Perceived toxicity of currently applied pesticide products, mix pesticides without gloves, regularly maintain and wash sprayer tank after application, occurrence of an incidental splash during mixing and application, and using home-based care after experiencing a symptom presumably due to pesticide exposure were significantly associated with health eects among applicators. Use of face mask and visiting health facility when experiencing a symptom presumably due to pesticide exposure were significantly positively correlated with attending training on the health risks and use of pesticides. A substantial proportion of applicators reported improper use of preventive measures and methods of pesticide waste disposal. These observations point out that applicators can face high health risks of occupational pesticide exposure in Ethiopia. Even trained applicators pursued poor preventive practices; hence, comprehensive practice-oriented in-depth Frontiers in Public Health 01 frontiersi Tessema et al. 10.3389/fpubh.2022.1017189 training focusing on safety precautions and proper use of personal protective equipment, and provision of adequate pesticide waste disposal means are crucial interventions.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Public Health. - 10 (2022), p. 1-18. -
További szerzők:	Nagy Károly (1986-) (népegészségügyi felügyelő) Ádám Balázs (1973-) (megelőző orvostan és népegészségtan szakorvos)
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001-es BibID:	BIBFORM097170
035-os BibID:	(cikkazonosító)10431 (WOS)000708214200001 (Scopus)85116214580
Első szerző:	Tessema, Roba Argaw
Cím:	Pesticide Use, Perceived Health Risks and Management in Ethiopia and in Hungary : a Comparative Analysis / Roba Argaw Tessema, Károly Nagy, Balázs Ádám
Dátum:	2021
ISSN:	1661-7827 1660-4601
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	International Journal of Environmental Research and Public Health. - 18 : 19 (2021), p. 1-15. -
További szerzők:	Nagy Károly (1986-) (népegészségügyi felügyelő) Ádám Balázs (1973-) (megelőző orvostan és népegészségtan szakorvos)
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