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001-es BibID:	BIBFORM113832
Első szerző:	Astuti, Putri Kusuma (állattenyésztési genetikus)
Cím:	Heat Stress: Can Animals be Stressed but still be Healthy? / Putri Kusuma Astuti, Roland Fajardo, George Wanjala, Nelly Kichamu, Husein Ohran, Bouabid Badaoui, Zoltán Bagi, Szilvia Kusza
Dátum:	2023
ISSN:	1841-9364 2344-4576
Megjegyzések:	In this era of rapid climate change, heat stress has emerged as a major problem for sheep farming. The quantity and quality of sheep production, as well as the welfare, are all shown to be negatively impacted by heat stress. Reduced cellular immune function in sheep exposed to high temperatures increases susceptibility to various diseases,although the underlying mechanisms are unclear. The imbalance between oxidants and antioxidants, known as oxidative stress, negatively impacts animal health due to heat stress-induced impairments in immune responses, increased production of reactive oxygen species, and/or a lack of antioxidants. Heat stress in livestock has negative effects on both the cell-mediated and humoral immune responses. However, the negative effects of heat stress on immune response in sheep can vary by breed. This review discusses how heat stress affects sheep's immunity. An overview of some molecular markers related to immunity, such as interleukin (ILs), Toll-like receptors (TLRs), and also the heat stress protein (HSPs) in sheep, is also discussed. Finally, recent researchon the effects of antioxidant supplementation and other promising nutritional strategies for reducing heat stress and improving animal health is presented.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok konferenciacikk folyóiratcikk animal health antioxidant heat stress immunity sheep
Megjelenés:	Scientific Papers: Animal Science and Biotechnologies. - 56 : 1 (2023), p. 194-202. -
További szerzők:	Fajardo, Roland Wanjala, George (1984-) (Animal scientist) Kichamu, Nelly (1978-) (Animal scientist) Ohran, Husein Badaoui, Bouabid (1979-) (animal genetics engineer) Bagi Zoltán (1987-) (természetvédelmi mérnök, állatgenetika) Kusza Szilvia (1979-) (agrármérnök)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM112083
Első szerző:	Astuti, Putri Kusuma (állattenyésztési genetikus)
Cím:	Heat stress: Can animals be stressed but still be healthy? / Putri Kusuma Astuti, Roland Fajardo, George Wanjala, Husein Ohran, Bouabid Badaoui, Zoltán Bagi, Szilvia Kusza
Dátum:	2023
ISSN:	2821-4293
Megjegyzések:	In this era of rapid climate change, heat stress has emerged as a major problem for sheep farming. The quantity and quality of sheep production, as well as the welfare, are all shown to be negatively impacted by heat stress. Reduced cellular immune function in sheep exposed to high temperatures increases susceptibility to various diseases, although the underlying mechanisms are unclear. The imbalance between oxidants and antioxidants, known as oxidative stress, negatively impacts animal health due to heat stress-induced impairments in immune responses, increased production of reactive oxygen species, and/or a lack of antioxidants. Heat stress in livestock has negative effects on both the cell-mediated and humoral immune responses. However, the negative effects of heat stress on immune response in sheep can vary by breed. This review discusses how heat stress affects sheep's immunity. An overview of some molecular markers related to immunity, such as interleukin (ILs), Toll-like receptors (TLRs), and also the heat stress protein (HSPs) in sheep, is also discussed. Finally, recent research on the effects of antioxidant supplementation and other promising nutritional strategies for reducing heat stress and improving animal health is presented.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok előadáskivonat könyvrészlet animal health antioxidant heat stress immunity sheep
Megjelenés:	Book of abstract : Multidisciplinary Conference on Sustainable Development : 25-26 May 2023 : Section : Animal Resources Bioengineering. - p. 17. -
További szerzők:	Fajardo, Roland Wanjala, George (1984-) (Animal scientist) Ohran, Husein Badaoui, Bouabid (1979-) (animal genetics engineer) Bagi Zoltán (1987-) (természetvédelmi mérnök, állatgenetika) Kusza Szilvia (1979-) (agrármérnök)
Pályázati támogatás:	2021-1.2.4-TÉT-2021-00047 Egyéb 2021-1.2.4-TÉT-2021-00014 Egyéb
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM106134
035-os BibID:	(cikkazonosító)22348 (WOS)000904416000001 (Scopus)85144635665
Első szerző:	Astuti, Putri Kusuma (állattenyésztési genetikus)
Cím:	Validation of SNP markers for thermotolerance adaptation in Ovis aries adapted to different climatic regions using KASP-PCR technique / Putri Kusuma Astuti, Daniela Elena Ilie, Dinu Gavojdian, George Wanjala, Bouabid Badaoui, Husein Ohran, Eva Pasic-Juhas, Zoltán Bagi, András Jávor, Szilvia Kusza
Dátum:	2022
ISSN:	2045-2322
Megjegyzések:	A study on 51 SNPs belonging to 29 genes related to heat stress was carried out in 720 sheep from 17 different breeds adapted to different climates from Hungary, Bosnia and Herzegovina, Morocco and Romania, using Kompetitive Allele?Specific Polymerase Chain Reaction. Genotype frequency and the Hardy?Weinberg equilibrium were calculated, followed by a clustering using the Principal Component Analysis. We analyzed the polymorphisms in the following genes analyzed: HSPA12A, HSP90AA1, IL33, DIO2, BTNL2, CSN2, ABCG1, CSN1S1, GHR, HSPA8, STAT3, and HCRT. We emphasized on HSPA12A and HSPA8 genes as they were successfully genotyped in all studied flocks in which genotype frequency patterns were identified. Contrary to previous findings, the A allele for HSPA8 SNP was not observed in the heat tolerant breeds, being found exclusively in cold-tolerant breeds. The principal component analysis could not clearly differentiate the breeds, while plot concentration was slightly varied among the three groups, with HSP90AA1 and IL33 SNPs' loading values significantly contributing to PC1 and PC2. We confirmed previous works that the HSPA12A, HSPA8, HSP90AA1 and IL33 SNPs are potential candidate markers for thermotolerance adaptation in sheep. This research contributes to the genetic variability of SNPs for thermotolerance adaptability in sheep.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Scientific Reports. - 12 (2022), p. 1-9. -
További szerzők:	Ilie, Daniela Elena Gavojdian, Dinu Wanjala, George (1984-) (Animal scientist) Badaoui, Bouabid (1979-) (animal genetics engineer) Ohran, Husein Pasic-Juhas, Eva Bagi Zoltán (1987-) (természetvédelmi mérnök, állatgenetika) Jávor András (1952-) (agrármérnök) Kusza Szilvia (1979-) (agrármérnök)
Pályázati támogatás:	EFOP-3.6.2-16-2017-00001 EFOP 2021-1.2.4-TÉT-2021-00014 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM122767
Első szerző:	Kusza Szilvia (agrármérnök)
Cím:	Insights into the genomic homogeneity of Moroccan indigenous sheep breeds though the lens of runs of homozygosity / Szilvia Kusza, Bouabid Badaoui, George Wanjala
Dátum:	2024
ISSN:	2045-2322
Megjegyzések:	Numerous studies have indicated that Morocco`s indigenous sheep breeds are genetically homogenous, posing a risk to their survival in the challenging harsh climate conditions where they predominantly inhabit. To understand the genetic behind genetic homogeneity through the lens of runs of homozygosity (ROH), we analyzed the whole genome sequences of fve indigenous sheep breeds (Beni Guil, Ouled Djellal, D`man, Sardi, Timahdite and Admixed).The results from principal component, admixture, Fst, and neighbour joining tree analyses consistently showed a homogenous genetic structure. This structure was characterized by an average length of 1.83 Mb for runs of homozygosity (ROH) segments, with a limited number of long ROH segments (24-48 Mb and> 48 Mb). The most common ROH segments were those ranging from 1-6 Mb. The most signifcant regions of homozygosity (ROH Islands) were mostly observed in two chromosomes, namely Chr1 and Chr5. Specifcally, ROH Islands were exclusively discovered in the Ouled Djellal breed on Chr1, whereas Chr5 exhibited ROH Islands in all breeds. The analysis of ROH Island and iHS technique was employed to detect signatures of selection on Chr1 and Chr5. The results indicate that Chr5 had a high level of homogeneity, with the same genes being discovered across all breeds. In contrast, Chr1 displays some genetic variances between breeds. Genes identifed on Chr5 included SLC39A1, IL23A, CAST, IL5, IL13, and IL4 which are responsible for immune response while genes identifed on Chr1 include SOD1, SLAMF9, RTP4, CLDN1, and PRKAA2. ROH segment profle and efective population sizes patterns suggests that the genetic uniformity of studied breeds is the outcome of events that transpired between 250 and 300 generations ago. This research not only contributes to the understanding of ROH distribution across breeds but helps design and implement native sheep breeding and conservation strategies in Morocco. Future research, incorporating a broader sample size and utilizing the pangenome for reference, is recommended to further elucidate these breeds` genomic landscapes and adaptive mechanisms.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Genomic homogeneity Indigenous sheep Morocco ROH
Megjelenés:	Scientific Reports. - 14:1(2024), p. 1-11. -
További szerzők:	Badaoui, Bouabid (1979-) (animal genetics engineer) Wanjala, George (1984-) (Animal scientist)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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