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001-es BibID:BIBFORM108316
035-os BibID:(WOS)000186399200009 (Scopus)0141532923
Első szerző:Varga János Tamás (Budapest)
Cím:Diversity of polyketide synthase gene sequences in Aspergillus species / János Varga, Krisztina Rigó, Sándor Kocsubé, Balázs Farkas, Károly Pál
Dátum:2003
ISSN:0923-2508
Megjegyzések:Fungal polyketide synthases are responsible for the biosynthesis of several mycotoxins and other secondary metabolites. The aim of our work was to investigate the diversity of polyketide synthases in Aspergillus species using two approaches: PCR amplification using oligonucleotide primers, and bioinformatics. Ketosynthase domain probes amplified DNA fragments of about 700 bp in each examined isolate. Sequences of these domains were aligned and analyzed by phylogenetic methods. The ketosynthase domain sequences were highly diverse indicating that they most probably represent polyketide synthases responsible for different functions. A. albertensis and A. niger ketosynthase domain sequences clustered together with sequences of genes required for pigment biosynthesis (wA) in A. nidulans and P. patulum, while the ketosynthase domain sequence of A. muricatus was most closely related to an A. parasiticus wA type domain sequence, and those of the A. ochraceus isolates formed a distinct clade on the tree. These sequences were highly homologous to an A. terreus naphthopyrone synthase gene. An Aspergillus fumigatus genomic database was also searched for ketosynthase domain sequences, which have been included in the phylogenetic analysis. Altogether 14 putative ketosynthase domain sequences were identified. Clustering of the ketosynthase domain sequences correlated well with the type of metabolites produced by the corresponding polyketide synthases. At least 8 clusters with putative ketosynthase domain sequences of unknown function have been identified. Further studies are in progress to clarify the role of some of the identified polyketide synthase genes.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Aspergillus
genomics
ketosynthase domain
mycotoxin
ochratoxin
phylogenetics
polyketide synthase
Megjelenés:Research In Microbiology. - 154 : 8 (2003), p. 593-600. -
További szerzők:Rigó Krisztina Kocsubé Sándor Farkas Balázs Pál Károly (1978-) (mikrobiológus)
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001-es BibID:BIBFORM117562
Első szerző:Varga János
Cím:Evolutionary Relationships among Economically Important Species of Aspergillus Subgenera Aspergillus and Fumigati / János Varga, Krisztina Rigó, Sándor Kocsubé, Károly Pál, Beáta Tóth, Robert A. Samson, Zotia Kozaki Ewicz
Dátum:2006
Megjegyzések:The genus Aspergillus is one of the most important filamentous fungal genera. Aspergillus species are used for the production of several enzymes, drugs and other metabolites useful for mankind. On the other hand, Aspergillus species produce a range of mycotoxins harmful to humans and animals, and can also cause several human and animal diseases. Molecular techniques enabled mycologists to get an insight into the phylogenetics of Aspergilli, and the evolution of mycotoxin production with special emphasis on aflatoxin biosynthesis. Phylogenetically unrelated species were found to produce the same mycotoxins. For example, aflatoxins have been produced under laboratory conditions by species belonging to three different sections, while ochratoxin A and patulin are produced by a variety of unrelated species. Based on this observation, mycotoxin-producing abilities of the isolates were lost (or gained) several times during the evolution of the genus. In this review, attempts have been made to summarize the current knowledge on the taxonomy of economically important Aspergilli belonging to Aspergillus subgenera Aspergillus and Fumigati, and on the evolution of mycotoxin production.
ISBN:9781578084135
Tárgyszavak:Természettudományok Biológiai tudományok könyvfejezet
könyvrészlet
Aflatoxin
Eurotium
Neosartorya
Petromyces
ochratoxin
phylogenetics
taxonomy
Megjelenés:Plant Genome: Biodiversity and EvolutionVol. 2, Part B Lower Groups / eds. Arun Kumar Sharma, Archana Sharma. - p. 285-332. -
További szerzők:Rigó Krisztina Kocsubé Sándor Pál Károly (1978-) (mikrobiológus) Tóth Beáta Samson, Robert A. Kozaki Ewicz, Zotia
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