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001-es BibID:	BIBFORM103353
035-os BibID:	(Scopus)85015354198 (WOS)000374833800004
Első szerző:	Kissling, Esther
Cím:	I-MOVE multicentre case-control study 2010/11 to 2014/15 : is there within-season waning of influenza type/subtype vaccine effectiveness with increasing time since vaccination? / E. Kissling, B. Nunes, C. Robertson, M. Valenciano, A. Reuss, A. Larrauri, J. M. Cohen, Beatrix Oroszi, C. Rizzo, A. Machado, D. Pitigoi, L. Domegan, I. Paradowska-Stankiewicz, U. Buchholz, A. Gherasim, I. Daviaud, J. K. Horváth, A. Bella, E. Lupulescu, J. O'Donnell, M. Korczyńska, A. Moren, I-MOVE case-control study team
Dátum:	2016
ISSN:	1560-7917
Megjegyzések:	Since the 2008/9 influenza season, the I-MOVE multicentre case?control study measures influenza vaccine effectiveness (VE) against medically-attended influenza-like-illness (ILI) laboratory confirmed as influenza. In 2011/12, European studies reported a decline in VE against influenza A(H3N2) within the season. Using combined I-MOVE data from 2010/11 to 2014/15 we studied the effects of time since vaccination on influenza type/subtype-specific VE. We modelled influenza type/subtype-specific VE by time since vaccination using a restricted cubic spline, controlling for potential confounders (age, sex, time of onset, chronic conditions). Over 10,000 ILI cases were included in each analysis of influenza A(H3N2), A(H1N1)pdm09 and B; with 4,759, 3,152 and 3,617 influenza positive cases respectively. VE against influenza A(H3N2) reached 50.6% (95% CI: 30.0?65.1) 38 days after vaccination, declined to 0% (95% CI: -18.1?15.2) from 111 days onwards. At day 54 VE against influenza A(H1N1)pdm09 reached 55.3% (95% CI: 37.9?67.9) and remained between this value and 50.3% (95% CI: 34.8?62.1) until season end. VE against influenza B declined from 70.7% (95% CI: 51.3?82.4) 44 days after vaccination to 21.4% (95% CI: -57.4?60.8) at season end. To assess if vaccination campaign strategies need revising more evidence on VE by time since vaccination is urgently needed.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Euro surveillance. - 21 : 16 (2016), p. 1-12. -
További szerzők:	Nunes, Baltazar Robertson, Chris Valenciano, Marta Reuss, Annicka Larrauri, Amparo Cohen, Jean Marie Oroszi Beatrix (1970-) (orvos, epidemiológus) Rizzo, Caterina Machado, Ausenda Pitigoi, Daniela Domegan, Lisa Paradowska-Stankiewicz, Iwona Buchholz, Udo Gherasim, Alin Daviaud, Isabelle Horváth Judit Krisztina Bella, Antonino Lupulescu, Emilia O'Donnell, Joan Korczyńska, Monika Moren, Alain I-MOVE case-control study team
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001-es BibID:	BIBFORM103350
035-os BibID:	(Scopus)76449094520 (WOS)000272247100007 (cikkazonosító)19388
Első szerző:	Kissling, Esther
Cím:	"I-MOVE" towards monitoring seasonal and pandemic influenza vaccine effectiveness : lessons learnt from a pilot multi-centric case-control study in Europe, 2008-9 / E. Kissling, M. Valenciano, J. M. Falcão, A. Larrauri, K. Widgren, D. Pitigoi, B. Oroszi, B. Nunes, C. Savulescu, A. Mazick, E. Lupulescu, B. Ciancio, A. Moren
Dátum:	2009
ISSN:	1025-496X 1560-7917
Megjegyzések:	Within I-MOVE (European programme to monitor seasonal and pandemic influenza vaccine effectiveness (IVE)) five countries conducted IVE pilot case-control studies in 2008-9. One hundred and sixty sentinel general practitioners (GP) swabbed all elderly consulting for influenza-like illness (ILI). Influenza confirmed cases were compared to influenza negative controls. We conducted a pooled analysis to obtain a summary IVE in the age group of ?65 years. We measured IVE in each study and assessed heterogeneity between studies qualitatively and using the I2 index. We used a one-stage pooled model with study as a fixed effect. We adjusted estimates for age-group, sex, chronic diseases, smoking, functional status, previous influenza vaccinations and previous hospitalisations. The pooled analysis included 138 cases and 189 test-negative controls. There was no statistical heterogeneity (I2=0) between studies but ILI case definition, previous hospitalisations and functional status were slightly different. The adjusted IVE was 59.1% (95% CI: 15.3-80.3%). IVE was 65.4% (95% CI: 15.6-85.8%) in the 65-74, 59.6% (95% CI: -72.6 -90.6%) in the age group of ?75 and 56.4% (95% CI: -0.2-81.3%) for A(H3). Pooled analysis is feasible among European studies. The variables definitions need further standardisation. Larger sample sizes are needed to achieve greater precision for subgroup analysis. For 2009-10, I-MOVE will extend the study to obtain early IVE estimates in groups targeted for pandemic H1N1 influenza vaccination.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Eurosurveillance. - 14 : 44 (2009), p. 29-36. -
További szerzők:	Valenciano, Marta Falcão, J. M. Larrauri, Amparo Widgren, K. Pitigoi, Daniela Oroszi Beatrix (1970-) (orvos, epidemiológus) Nunes, Baltazar Savulescu, Camelia Mazick, A. Lupulescu, Emilia Ciancio, Bruno Moren, Alain
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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