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001-es BibID:	BIBFORM103349
035-os BibID:	(Scopus)85095439018 (WOS)000598859700001
Első szerző:	Csanádi Marcell
Cím:	Modeling costs and benefits of the organized colorectal cancer screening programme and its potential future improvements in Hungary / Marcell Csanádi, Andrea Gini, Harry de Koning, György Széles, János G. Pitter, Beatrix Oroszi, Piroska Pataki, Petra Fadgyas-Freyler, Gyula Korponai, Zoltán Vokó, Iris Lansdorp-Vogelaar
Dátum:	2020
ISSN:	0969-1413
Megjegyzések:	Objective The national population-based colorectal cancer screening programme in Hungary was initiated in December 2018. We aimed to evaluate the current programme and investigate the costs and benefits of potential future changes to overcome the low coverage of the target population. Methods We performed an economic evaluation from a healthcare payer perspective using an established micro-simulation model (Microsimulation Screening Analysis-Colon). We simulated costs and benefits of screening with fecal immunochemical test in the Hungarian population aged 50?100, investigating also the impact of potential future scenarios which were assumed to increase invitation coverage: improvement of the IT platform currently used by GPs or distributing the tests through pharmacies instead of GPs. Results The model predicted that the current screening programme could lead to 6.2% colorectal cancer mortality reduction between 2018 and 2050 compared to no screening. Even higher reductions, up to 16.6%, were estimated when tests were distributed through pharmacies and higher coverage was assumed. This change in the programme was estimated to require up to 26 million performed fecal immunochemical tests and 1 million colonoscopies for the simulated period. These future scenarios have acceptable cost-benefit ratios of ?8000??8700 per life-years gained depending on the assumed adherence of invited individuals. Conclusions With its limitations, the current colorectal cancer screening programme in Hungary will have a modest impact on colorectal cancer mortality. Significant improvements in mortality reduction could be made at acceptable costs, if the tests were to be distributed by pharmacies allowing the entire target population to be invited.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Colorectal cancer screening national screening programme economic evaluation costs and benefits
Megjelenés:	Journal Of Medical Screening. - 28 : 3 (2020), p. 268-276. -
További szerzők:	Gini Andrea Koning, Harry de Széles György (1969-) (epidemiológus) Pitter János György Oroszi Beatrix (1970-) (orvos, epidemiológus) Pataki Piroska Fadgyas-Freyler Petra Korponai Gyula Vokó Zoltán (1968-) (epidemiológus) Lansdorp-Vogelaar, Iris
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001-es BibID:	BIBFORM087281
035-os BibID:	(WOS)000555540500004 (Scopus)85088021387
Első szerző:	Merkely Béla (orvos)
Cím:	Novel coronavirus epidemic in the Hungarian population, a cross-sectional nationwide survey to support the exit policy in Hungary / Béla Merkely, Attila J. Szabó, Annamária Kosztin, Ervin Berényi, Andor Sebestyén, Csaba Lengyel, Gergő Merkely, Júlia Karády, István Várkonyi, Csaba Papp, Attila Miseta, József Betlehem, Katalin Burián, Ildikó Csóka, Barna Vásárhelyi, Endre Ludwig, Gyula Prinz, János Sinkó, Balázs Hankó, Péter Varga, Gábor Áron Fülöp, Kornélia Mag, Zoltán Vokó, HUNgarian COronaVirus-19 Epidemiological Research (H-UNCOVER) investigators
Dátum:	2020
ISSN:	2509-2715 2509-2723
Megjegyzések:	After months of restrictive containment efforts to fight the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemic, European countries are planning to reopen. To support the process, we conducted a cross-sectional survey among the Hungarian population to estimate the prevalence of infectious cases and prior SARS-CoV-2 exposure. A representative sample (n = 17,787) for the Hungarian population of 14 years or older living in private households (n = 8,283,810) was selected. The study was performed within 16 days after 50 days of restrictions, when the number of confirmed cases was stable low. Naso- and oropharyngeal smears and blood samples were collected for PCR and antibody testing. The testing was accompanied by a questionnaire about symptoms, comorbidities, and contacts. Design-based prevalence estimates were calculated. In total, 10,474 individuals (67.7% taken into account a sample frame error of 2315) of the selected sample participated in the survey. Of the tested individuals, 3 had positive PCR and 69 had positive serological test. Population estimate of the number of SARS-CoV-2 infection and seropositivity were 2421 and 56,439, respectively, thus active infection rate (2.9/10,000) and the prevalence of prior SARS-CoV-2 exposure (68/10,000) was low. Self-reported loss of smell or taste and body aches were significantly more frequent among those with SARS-CoV-2. In this representative, cross-sectional survey of the Hungarian population with a high participation rate, the overall active infection rate was low in sync with the prevalence of prior SARS-CoV-2 exposure. We demonstrated a potential success of containment efforts, supporting an exit strategy.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk COVID-19 SARS-CoV-2 Hungary
Megjelenés:	GeroScience. - 42 : 4 (2020), p. 1063-1074. -
További szerzők:	Szabó Attila (gyermekgyógyász Budapest) Kosztin Annamária Berényi Ervin (1964-) (radiológus) Sebestyén Andor Lengyel Csaba (Szeged) Merkely Gergő Karády Júlia Várkonyi István (1973-) (orvos) Papp Csaba (1966-) (aneszteziológus és intenzív terápiás szakorvos) Miseta Attila Betlehem József Burián Katalin Csóka Ildikó Vásárhelyi Barna Ludwig Endre Prinz Gyula Sinkó János Hankó Balázs Varga Péter (szülész-nőgyógyász) Fülöp Gábor Áron (1988-) (általános orvos) Mag Kornélia Vokó Zoltán (1968-) (epidemiológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Oroszi Beatrix (1970-) (orvos, epidemiológus) HUNgarian COronaVirus-19 Epidemiological Research (H-UNCOVER) investigators
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