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001-es BibID:	BIBFORM103357
035-os BibID:	(cikkazonosító)e27622 (WOS)000297555300037 (Scopus)81055129712
Első szerző:	Kissling, Esther
Cím:	I-MOVE Multi-Centre Case Control Study 2010-11 : overall and Stratified Estimates of Influenza Vaccine Effectiveness in Europe / Esther Kissling, Marta Valenciano, Jean Marie Cohen, Beatrix Oroszi, Anne-Sophie Barret, Caterina Rizzo, Pawel Stefanoff, Baltazar Nunes, Daniela Pitigoi, Amparo Larrauri, Isabelle Daviaud, Judit Krisztina Horvath, Joan O'Donnell, Thomas Seyler, Iwona Anna Paradowska-Stankiewicz, Pedro Pechirra, Alina Elena Ivanciuc, Silvia Jiménez-Jorge, Camelia Savulescu, Bruno Christian Ciancio, Alain Moren
Dátum:	2011
ISSN:	1932-6203
Megjegyzések:	Background: In the third season of I-MOVE (Influenza Monitoring Vaccine Effectiveness in Europe), we undertook a multicentre case-control study based on sentinel practitioner surveillance networks in eight European Union (EU) member states to estimate 2010/11 influenza vaccine effectiveness (VE) against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza. Methods: Using systematic sampling, practitioners swabbed ILI/ARI patients within seven days of symptom onset. We compared influenza-positive to influenza laboratory-negative patients among those meeting the EU ILI case definition. A valid vaccination corresponded to > 14 days between receiving a dose of vaccine and symptom onset. We used multiple imputation with chained equations to estimate missing values. Using logistic regression with study as fixed effect we calculated influenza VE adjusting for potential confounders. We estimated influenza VE overall, by influenza type, age group and among the target group for vaccination. Results: We included 2019 cases and 2391 controls in the analysis. Adjusted VE was 52% (95% CI 30-67) overall (N = 4410), 55% (95% CI 29-72) against A(H1N1) and 50% (95% CI 14-71) against influenza B. Adjusted VE against all influenza subtypes was 66% (95% CI 15-86), 41% (95% CI -3-66) and 60% (95% CI 17-81) among those aged 0-14, 15-59 and ?60 respectively. Among target groups for vaccination (N = 1004), VE was 56% (95% CI 34-71) overall, 59% (95% CI 32-75) against A(H1N1) and 63% (95% CI 31-81) against influenza B. Conclusions: Results suggest moderate protection from 2010-11 trivalent influenza vaccines against medically-attended ILI laboratory-confirmed as influenza across Europe. Adjusted and stratified influenza VE estimates are possible with the large sample size of this multi-centre case-control. I-MOVE shows how a network can provide precise summary VE measures across Europe.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Plos One. - 6 : 11 (2011), p. 1-11. -
További szerzők:	Valenciano, Marta Cohen, Jean Marie Oroszi Beatrix (1970-) (orvos, epidemiológus) Barret, Anne-Sophie Rizzo, Caterina Stefanoff, Pawel Nunes, Baltazar Pitigoi, Daniela Larrauri, Amparo Daviaud, Isabelle Horváth Judit Krisztina O'Donnell, Joan Seyler, Thomas Paradowska-Stankiewicz, Iwona Pechirra, Pedro Ivanciuc, Alina Elena Jiménez-Jorge, Silvia Savulescu, Camelia Ciancio, Bruno Moren, Alain
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM103353
035-os BibID:	(Scopus)85015354198 (WOS)000374833800004
Első szerző:	Kissling, Esther
Cím:	I-MOVE multicentre case-control study 2010/11 to 2014/15 : is there within-season waning of influenza type/subtype vaccine effectiveness with increasing time since vaccination? / E. Kissling, B. Nunes, C. Robertson, M. Valenciano, A. Reuss, A. Larrauri, J. M. Cohen, Beatrix Oroszi, C. Rizzo, A. Machado, D. Pitigoi, L. Domegan, I. Paradowska-Stankiewicz, U. Buchholz, A. Gherasim, I. Daviaud, J. K. Horváth, A. Bella, E. Lupulescu, J. O'Donnell, M. Korczyńska, A. Moren, I-MOVE case-control study team
Dátum:	2016
ISSN:	1560-7917
Megjegyzések:	Since the 2008/9 influenza season, the I-MOVE multicentre case?control study measures influenza vaccine effectiveness (VE) against medically-attended influenza-like-illness (ILI) laboratory confirmed as influenza. In 2011/12, European studies reported a decline in VE against influenza A(H3N2) within the season. Using combined I-MOVE data from 2010/11 to 2014/15 we studied the effects of time since vaccination on influenza type/subtype-specific VE. We modelled influenza type/subtype-specific VE by time since vaccination using a restricted cubic spline, controlling for potential confounders (age, sex, time of onset, chronic conditions). Over 10,000 ILI cases were included in each analysis of influenza A(H3N2), A(H1N1)pdm09 and B; with 4,759, 3,152 and 3,617 influenza positive cases respectively. VE against influenza A(H3N2) reached 50.6% (95% CI: 30.0?65.1) 38 days after vaccination, declined to 0% (95% CI: -18.1?15.2) from 111 days onwards. At day 54 VE against influenza A(H1N1)pdm09 reached 55.3% (95% CI: 37.9?67.9) and remained between this value and 50.3% (95% CI: 34.8?62.1) until season end. VE against influenza B declined from 70.7% (95% CI: 51.3?82.4) 44 days after vaccination to 21.4% (95% CI: -57.4?60.8) at season end. To assess if vaccination campaign strategies need revising more evidence on VE by time since vaccination is urgently needed.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Euro surveillance. - 21 : 16 (2016), p. 1-12. -
További szerzők:	Nunes, Baltazar Robertson, Chris Valenciano, Marta Reuss, Annicka Larrauri, Amparo Cohen, Jean Marie Oroszi Beatrix (1970-) (orvos, epidemiológus) Rizzo, Caterina Machado, Ausenda Pitigoi, Daniela Domegan, Lisa Paradowska-Stankiewicz, Iwona Buchholz, Udo Gherasim, Alin Daviaud, Isabelle Horváth Judit Krisztina Bella, Antonino Lupulescu, Emilia O'Donnell, Joan Korczyńska, Monika Moren, Alain I-MOVE case-control study team
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM103352
035-os BibID:	(Scopus)84873314436
Első szerző:	Kissling, Esther
Cím:	Low and decreasing vaccine effectiveness against influenza A(H3) in 2011/12 among vaccination target groups in Europe : results from the I-MOVE multicentre case-control study / E. Kissling, M. Valenciano, A. Larrauri, B. Oroszi, J. M. Cohen, B. Nunes, D. Pitigoi, C. Rizzo, J. Rebolledo, I. Paradowska-Stankiewicz, S. Jiménez-Jorge, J. K. Horváth, I. Daviaud, R. Guiomar, G. Necula, A. Bella, J. O'Donnell, M. Głuchowska, B. C. Ciancio, A. Nicoll, A. Moren
Dátum:	2013
ISSN:	1560-7917
Megjegyzések:	Within the Influenza Monitoring Vaccine Effectiveness in Europe (I-MOVE) project we conducted a multicentre case?control study in eight European Union (EU) Member States to estimate the 2011/12 influenza vaccine effectiveness against medically attended influenza-like illness (ILI) laboratory-confirmed as influenza A(H3) among the vaccination target groups. Practitioners systematically selected ILI / acute respiratory infection patients to swab within seven days of symptom onset. We restricted the study population to those meeting the EU ILI case definition and compared influenza A(H3) positive to influenza laboratory-negative patients. We used logistic regression with study site as fixed effect and calculated adjusted influenza vaccine effectiveness (IVE), controlling for potential confounders (age group, sex, month of symptom onset, chronic diseases and related hospitalisations, number of practitioner visits in the previous year). Adjusted IVE was 25% (95% confidence intervals (CI): -6 to 47) among all ages (n=1,014), 63% (95% CI: 26 to 82) in adults aged between 15 and 59 years and 15% (95% CI: -33 to 46) among those aged 60 years and above. Adjusted IVE was 38% (95%CI: -8 to 65) in the early influenza season (up to week 6 of 2012) and -1% (95% CI: -60 to 37) in the late phase. The results suggested a low adjusted IVE in 2011/12. The lower IVE in the late season could be due to virus changes through the season or waning immunity. Virological surveillance should be enhanced to quantify change over time and understand its relation with duration of immunological protection. Seasonal influenza vaccines should be improved to achieve acceptable levels of protection.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Eurosurveillance. - 18 : 5 (2013), p. 1-10. -
További szerzők:	Valenciano, Marta Larrauri, Amparo Oroszi Beatrix (1970-) (orvos, epidemiológus) Cohen, Jean Marie Nunes, Baltazar Pitigoi, Daniela Rizzo, Caterina Rebolledo, J. Paradowska-Stankiewicz, Iwona Jiménez-Jorge, Silvia Horváth, J. K. Daviaud, Isabelle Guiomar, Raquel Necula, G. Bella, Antonino O'Donnell, Joan Głuchowska, M. Ciancio, Bruno Nicoll, A. Moren, Alain
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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