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001-es BibID:	BIBFORM103352
035-os BibID:	(Scopus)84873314436
Első szerző:	Kissling, Esther
Cím:	Low and decreasing vaccine effectiveness against influenza A(H3) in 2011/12 among vaccination target groups in Europe : results from the I-MOVE multicentre case-control study / E. Kissling, M. Valenciano, A. Larrauri, B. Oroszi, J. M. Cohen, B. Nunes, D. Pitigoi, C. Rizzo, J. Rebolledo, I. Paradowska-Stankiewicz, S. Jiménez-Jorge, J. K. Horváth, I. Daviaud, R. Guiomar, G. Necula, A. Bella, J. O'Donnell, M. Głuchowska, B. C. Ciancio, A. Nicoll, A. Moren
Dátum:	2013
ISSN:	1560-7917
Megjegyzések:	Within the Influenza Monitoring Vaccine Effectiveness in Europe (I-MOVE) project we conducted a multicentre case?control study in eight European Union (EU) Member States to estimate the 2011/12 influenza vaccine effectiveness against medically attended influenza-like illness (ILI) laboratory-confirmed as influenza A(H3) among the vaccination target groups. Practitioners systematically selected ILI / acute respiratory infection patients to swab within seven days of symptom onset. We restricted the study population to those meeting the EU ILI case definition and compared influenza A(H3) positive to influenza laboratory-negative patients. We used logistic regression with study site as fixed effect and calculated adjusted influenza vaccine effectiveness (IVE), controlling for potential confounders (age group, sex, month of symptom onset, chronic diseases and related hospitalisations, number of practitioner visits in the previous year). Adjusted IVE was 25% (95% confidence intervals (CI): -6 to 47) among all ages (n=1,014), 63% (95% CI: 26 to 82) in adults aged between 15 and 59 years and 15% (95% CI: -33 to 46) among those aged 60 years and above. Adjusted IVE was 38% (95%CI: -8 to 65) in the early influenza season (up to week 6 of 2012) and -1% (95% CI: -60 to 37) in the late phase. The results suggested a low adjusted IVE in 2011/12. The lower IVE in the late season could be due to virus changes through the season or waning immunity. Virological surveillance should be enhanced to quantify change over time and understand its relation with duration of immunological protection. Seasonal influenza vaccines should be improved to achieve acceptable levels of protection.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Eurosurveillance. - 18 : 5 (2013), p. 1-10. -
További szerzők:	Valenciano, Marta Larrauri, Amparo Oroszi Beatrix (1970-) (orvos, epidemiológus) Cohen, Jean Marie Nunes, Baltazar Pitigoi, Daniela Rizzo, Caterina Rebolledo, J. Paradowska-Stankiewicz, Iwona Jiménez-Jorge, Silvia Horváth, J. K. Daviaud, Isabelle Guiomar, Raquel Necula, G. Bella, Antonino O'Donnell, Joan Głuchowska, M. Ciancio, Bruno Nicoll, A. Moren, Alain
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM103358
035-os BibID:	(cikkazonosító)e1000388 (WOS)000286594200004 (Scopus)79951650357
Első szerző:	Valenciano, Marta
Cím:	Estimates of Pandemic Influenza Vaccine Effectiveness in Europe, 2009-2010 : results of Influenza Monitoring Vaccine Effectiveness in Europe (I-MOVE) Multicentre Case-Control Study / Marta Valenciano, Esther Kissling, Jean-Marie Cohen, Beatrix Oroszi, Anne-Sophie Barret, Caterina Rizzo, Baltazar Nunes, Daniela Pitigoi, Amparro Larrauri Cámara, Anne Mosnier, Judith K. Horvath, Joan O'Donnell, Antonino Bella, Raquel Guiomar, Emilia Lupulescu, Camelia Savulescu, Bruno C. Ciancio, Piotr Kramarz, Alain Moren
Dátum:	2011
ISSN:	1549-1676
Megjegyzések:	Background: A multicentre case-control study based on sentinel practitioner surveillance networks from seven European countries was undertaken to estimate the effectiveness of 2009-2010 pandemic and seasonal influenza vaccines against medically attended influenza-like illness (ILI) laboratory-confirmed as pandemic influenza A (H1N1) (pH1N1). Methods and findings: Sentinel practitioners swabbed ILI patients using systematic sampling. We included in the study patients meeting the European ILI case definition with onset of symptoms >14 days after the start of national pandemic vaccination campaigns. We compared pH1N1 cases to influenza laboratory-negative controls. A valid vaccination corresponded to >14 days between receiving a dose of vaccine and symptom onset. We estimated pooled vaccine effectiveness (VE) as 1 minus the odds ratio with the study site as a fixed effect. Using logistic regression, we adjusted VE for potential confounding factors (age group, sex, month of onset, chronic diseases and related hospitalizations, smoking history, seasonal influenza vaccinations, practitioner visits in previous year). We conducted a complete case analysis excluding individuals with missing values and a multiple multivariate imputation to estimate missing values. The multivariate imputation (n = 2902) adjusted pandemic VE (PIVE) estimates were 71.9% (95% confidence interval [CI] 45.6-85.5) overall; 78.4% (95% CI 54.4-89.8) in patients <65 years; and 72.9% (95% CI 39.8-87.8) in individuals without chronic disease. The complete case (n = 1,502) adjusted PIVE were 66.0% (95% CI 23.9-84.8), 71.3% (95% CI 29.1-88.4), and 70.2% (95% CI 19.4-89.0), respectively. The adjusted PIVE was 66.0% (95% CI -69.9 to 93.2) if vaccinated 8-14 days before ILI onset. The adjusted 2009-2010 seasonal influenza VE was 9.9% (95% CI -65.2 to 50.9). Conclusions: Our results suggest good protection of the pandemic monovalent vaccine against medically attended pH1N1 and no effect of the 2009-2010 seasonal influenza vaccine. However, the late availability of the pandemic vaccine and subsequent limited coverage with this vaccine hampered our ability to study vaccine benefits during the outbreak period. Future studies should include estimation of the effectiveness of the new trivalent vaccine in the upcoming 2010-2011 season, when vaccination will occur before the influenza season starts.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	PLoS Medicine. - 8 : 1 (2011), p. 1-12. -
További szerzők:	Kissling, Esther Cohen, Jean Marie Oroszi Beatrix (1970-) (orvos, epidemiológus) Barret, Anne-Sophie Rizzo, Caterina Nunes, Baltazar Pitigoi, Daniela Larrauri Cámara, Amparro Mosnier, Anne Horváth Judit Krisztina O'Donnell, Joan Bella, Antonino Guiomar, Raquel Lupulescu, Emilia Savulescu, Camelia Ciancio, Bruno Kramarz, Piotr Moren, Alain
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