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001-es BibID:BIBFORM115693
035-os BibID:(Scopus)85116069914
Első szerző:Merzah, Mohammed
Cím:Catechol o-methyltransferase VAL158/MET and hypertension : a meta-analysis / Mohammed A. Merzah, Shewaye Natae
Dátum:2021
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Malaysian Journal of Public Health Medicine. - 21 : 2 (2021), p. 162-167. -
További szerzők:Natae, Shewaye (1982-) (PhD hallgató)
Pályázati támogatás:EFOP-3.6.1-16-2016-00022
EFOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM114683
035-os BibID:(cikkazonosító)13920 (WoS)001073617500001 (Scopus)85172771410
Első szerző:Merzah, Mohammed
Cím:A Transcriptomic Analysis of Smoking-Induced Gene Expression Alterations in Coronary Artery Disease Patients / Mohammed Merzah, Szilárd Póliska, László Balogh, János Sándor, István Szász, Shewaye Natae, Szilvia Fiatal
Dátum:2023
ISSN:1422-0067
Megjegyzések:Abstract: Smoking is a well established risk factor for coronary artery disease (CAD). Despite this, there have been no previous studies investigating the effects of smoking on blood gene expression in CAD patients. This single-centre cross-sectional study was designed with clearly defined inclusion criteria to address this gap. We conducted a high-throughput approach using next generation sequencing analysis with a single-end sequencing protocol and a read length of 75-cycles. Sixty-one patients with a median age of 67 years (range: 28?88 years) were recruited, and only 44 subjects were included for further analyses. Our investigation revealed 120 differentially expressed genes (DEGs) between smokers and nonsmokers, with a fold change (FC) of ?1.5 and a p-value < 0.05. Among these DEGs, 15 were upregulated and 105 were downregulated. Notably, when applying a more stringent adjusted FC ? 2.0, 31 DEGs (5 upregulated, annotated to immune response pathways, and 26 downregulated, involving oxygen and haem binding or activity, with FDR ? 0.03) remained statistically significant at an alpha level of <0.05. Our results illuminate the molecular mechanisms underlying CAD, fortifying existing epidemiological evidence. Of particular interest is the unexplored overexpression of RCAN3, TRAV4, and JCHAIN genes, which may hold promising implications for the involvement of these genes in CAD among smokers.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
coronary artery disease
gene expression
smoking
NGS
RNAseq
Megjelenés:International Journal Of Molecular Sciences. - 24 : 18 (2023), p. 1-14. -
További szerzők:Póliska Szilárd (1978-) (biológus) Balogh László (1976-) (kardiológus) Sándor János (1966-) (orvos-epidemiológus) Szász István (1985-) (Ph.D hallgató) Natae, Shewaye (1982-) (PhD hallgató) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM092553
035-os BibID:(cikkazonosító)3206 (WOS)000639196000001 (Scopus)85102693631
Első szerző:Merzah, Mohammed
Cím:Roma Socioeconomic Status Has a Higher Impact on Smoking Behaviour than Genetic Susceptibility / Mohammed Merzah, Zsigmond Kósa, János Sándor, Shewaye Natae, Péter Pikó, Róza Ádány, Szilvia Fiatal
Dátum:2021
ISSN:1661-7827 1660-4601
Megjegyzések:It is a matter of speculation whether the high prevalence of smoking among Hungarian Roma (HR) is related to genetic, gene-environmental interactions or cultural factors. Our aim is to compare the genetic susceptibility and possible effects of determinants associated with smoking behaviours in the Hungarian general (HG) and Roma populations. A complex health survey including three pillars (questionnaire, physical and laboratory examinations) was carried out (NHG = 412 and NHR = 402). Risk allele frequencies of ten single-nucleotide polymorphisms (SNPs) were compared, and their combined effect was estimated by computing unweighted and weighted genetic risk scores (GRS, wGRS). The effects of genetic and environmental factors were investigated in regression analyses after confounders were introduced. Socio-economic status (SES) was calculated based on the Kuppuswamy scale 2019. Risk allele frequencies of only four SNPs were found to be different between populations (p < 0.01). Median values of GRS did not differ, while the wGRS median was slightly higher among Roma individuals (5.2 vs. 4.9; p = 0.02). Roma individuals were more likely to be heavy smokers (ORmales = 2.05, 95% CI [1.47?2.86]; ORfemales = 1.89, 95% CI [1.58? 2.25]. Smokers have lower SES compared to never smokers (SES ?HR = ?0.039, p = 0.023; ?HG = ?0.010, p = 0.049). An inverse relationship was found between SES and smoking behaviours (p < 0.0001) and was found to be a better predictor of smoking behaviours than genetic susceptibility. Our study findings suggest that the high prevalence of smoking behaviours and nicotine-dependence were not revealed to have a genetic susceptibility among HR individuals; therefore, the highest efforts should be focused on targeting SES-related factors in the Roma population. Strengths of the study: This is the first study carried out to investigate and detect the most relevant factors and the possible genetic background of the extremely high prevalence of smoking based in the Roma population. Limitations of the study: No standard instrument has been used to assess the intensity of addiction to nicotine. Because of some participants' unwillingness to define themselves as Roma, the overall HR population was not represented by the sample of this study.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
smoking behaviours
genetic susceptibility
Roma
socioeconomic status
SNP
Megjelenés:International Journal of Environmental Research and Public Health. - 18 : 6 (2021), p. 1-12. -
További szerzők:Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Natae, Shewaye (1982-) (PhD hallgató) Pikó Péter (1987-) (biológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
Egyéb
MTA11010 and TK2016-78
Egyéb
OTKA 135784
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM114684
Első szerző:Natae, Shewaye (PhD hallgató)
Cím:A combination of strongly associated prothrombotic single nucleotide polymorphisms could efficiently predict venous thrombosis risk / Shewaye Fituma Natae, Mohammed Abdulridha Merzah, János Sándor, Róza Ádány, Zsuzsanna Bereczky, Szilvia Fiatal
Dátum:2023
ISSN:2297-055X
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Cardiovascular Medicine. - 10 (2023), p. 1-11. -
További szerzők:Merzah, Mohammed (1985-) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
OTKA K139293
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM097589
035-os BibID:(cikkazonosító)647416
Első szerző:Natae, Shewaye (PhD hallgató)
Cím:The Higher Prevalence of Venous Thromboembolism in the Hungarian Roma Population Could Be Due to Elevated Genetic Risk and Stronger Gene-Environmental Interactions / Natae Shewaye Fituma, Kósa Zsigmond, Sándor János, Merzah Mohammed Abdulridha, Bereczky Zsuzsanna, Pikó Péter, Ádány Róza, Fiatal Szilvia
Dátum:2021
ISSN:2297-055X
Megjegyzések:Background: Interactions between genetic and environmental risk factors (GxE) contribute to an increased risk of venous thromboembolism (VTE). Understanding how these factors interact provides insight for the early identification of at-risk groups within a population and creates an opportunity to apply appropriate preventive and curative measures. Objective: To estimate and compare GxE for VTE risk in the general Hungarian and Roma populations. Methods: The study was based on data extracted from a database consisting of results previously obtained from a complex health survey with three pillars (questionnaire-based, physical, and laboratory examinations) involving 406 general Hungarian and 395 Roma subjects. DNA was genotyped for rs121909567 (SERPINC1), rs1799963 (F2), rs2036914 (F11), rs2066865 (FGG), rs6025 (F5), and rs8176719 (ABO) polymorphisms. After allele frequency comparisons, the odds ratio (OR) was calculated for individual SNPs. Furthermore, genetic risk scores (weighted GRS, unweighted GRS) were computed to estimate the joint effect of the genetic factors. Multivariable linear regression analysis was applied to test the impact of GxE on VTE risk after interaction terms were created between genetic and VTE risk factors [diabetes mellitus (DM), cancer, chronic kidney diseases (CKD), coronary artery diseases (CAD), migraine, depression, obesity, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein (HDL-C), triglyceride (TG), and smoking]. Results: Interestingly, the rs121909567 (SERPINC1, ATBp3 mutation) SNP was not present in the general population at all. However, the risk allele frequency was 1% among the Roma population, which might suggest a founder effect in this minority. This polymorphism multiplicatively interacted with CAD, CKD, cancer, DM, depression, migraine, and obesity. Even though interactions were not statistically significant, the trend of interaction showed the probability of an incremental VTE risk among the Roma population. The risk of VTE was 4.7 times higher (p > 0.05) for Roma subjects who had ?3 wGRS (median value) compared with individuals having lower wGRS values but lower for the general subjects (OR = 3.1 ? 10?8). Additionally, the risk of VTE was 6.6 times higher in the Roma population that had ?3 risk alleles (median value) than in individuals with the 0?1 risk allele, and the overall risk was much higher for the Roma population (OR = 6.6; p > 0.05) than for the general Hungarian population (OR = 1.5; p > 0.05). Five positive and significant GxE interactions were identified in the Roma population. The risk of VTE was higher among depressive Roma subjects who carried the risk variant rs2036914 ( = 0.819, p = 0.02); however, this interaction was not significant for the general subjects. The joint presence of high levels of LDL-C and rs2066865 (FGG) increased the VTE risk only among Roma individuals ( = 0.389, p = 0.002). The possibility of VTE risk increment, as a result of a multiplicative interaction between rs8176719 (ABO) and cancer, was identified, which was higher for the Roma population ( = 0.370, p < 0.001) than for the general population ( = ?0.042, p = 0.6). The VTE risk increased in the Roma population ( = 0.280, p = 0.001), but was higher in the general population ( = 0.423, p = 0.001) as a result of the multiplicative interaction between CAD and rs2036914 (F11). The presence of a multiplicative interaction between rs2066865 (FGG) and CAD increased the VTE risk for the Roma population ( = 0.143, p = 0.046) but not for the general population ( = ?0.329, p < 0.001). Conclusions: rs121909567 (SERPINC1, ATBp3) was confirmed as a founder mutation in the Roma population. Our study revealed some evidence on the burden of the joint presence of genetic and environmental risk factors on VTE, although the finding is highly subjected to the selection and observational biases due to the very small number of VTE cases and the observational nature of the study design, respectively. As a result of higher genetic load and GxE interactions, this minority Roma population is at higher risk of VTE than the general Hungarian population. Thus, our results suggest the need for an intensive search for the rs121909567 (SERPINC1; ATBp3) foundermutation, whichmight be an important factor for the assessment of thrombotic disease susceptibility among the Roma population. In addition, we strongly recommend further studies among a large number of VTE cases to explore the more precise impact of genetic and environmental risk factors on VTE in the study populations.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
VTE
GxE interactions
ATBp3 mutation
SERPINC1
Roma population
general Hungarian
Megjelenés:Frontiers in Cardiovascular Medicine. - 8 (2021), p. 1-13. -
További szerzők:Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Merzah, Mohammed (1985-) Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos) Pikó Péter (1987-) (biológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
Pályázati támogatás:Stipendium Hungaricum Scholarship Programme
Egyéb
GINOP-2.3.2-15-2016-00005
Egyéb
GINOP-2.3.2-15-2016- 00039
Egyéb
MTA11010
Egyéb
TK2016-78
Egyéb
OTKA K116228
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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