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1.

001-es BibID:BIBFORM109257
035-os BibID:(Scopus)85149477136 (WoS)000942239000001
Első szerző:Csernus Brigitta (élelmiszerbiztonsági és -minőségi mérnök)
Cím:Capsanthin supplementation modulates the immune response in broiler chickens under Escherichia coli lipopolysaccharide challenge / Brigitta Csernus, Csaba Szabó, Renáta Knop, Reda Gebrehaweria Kidane, Sawadi Fransisco Ndunguru, Gabriella Gulyás, Xénia Erika Ozsváth, Levente Czeglédi
Dátum:2023
ISSN:2363-9822
Megjegyzések:Due to the legislation of antibiotic usage, natural substances are required for application in the poultry industry. Because of their potential anti-inflammatory and immunomodulatory effects, carotenoids are great sources. Capsanthin, a major carotenoid giving the red color of pepper, is a promising feed additive, as it can reduce chronic inflammation. This study was conducted to determine the effects of capsanthin supplementation at 80 mg kg?1 in feed on the immune response of broiler chickens under Escherichia coli O55:B5 lipopolysaccharide (LPS) challenge. Ross 308 male broilers were divided into treatments: control (basal diet) and feedsupplemented groups. At 42 d of age, chickens were weighed and then challenged with 1 mg LPS per kilogram of body weight intraperitoneally. Four hours after injection, birds were euthanized, and then spleen and blood samples were collected. Capsanthin supplement at 80 mg kg?1 did not change the growth parameters and the relative spleen weight. LPS immunization resulted in higher splenic interleukin-1? (IL-1?), interleukin-6 (IL-6), and interferon-? (IFN-? ) mRNA expressions. Capsanthin addition reached lower gene expression levels of IL-6 and IFN-? compared to the LPS-injected birds. At plasma level, dietary capsanthin resulted in lower IL-1? and IL-6 levels. These results may indicate the potential anti-inflammatory effect of capsanthin supplementation in broiler chickens.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
capsanthin
broiler chicken
gene expression
immunology
Megjelenés:Archives Animal Breeding. - 66 : 1 (2023), p. 103-111. -
További szerzők:Szabó Csaba (1968-) (agrármérnök) Knop Renáta (1983-) (állatorvos) Reda, Gebrehaweria Kidane (Phd hallgató) Ndunguru, Sawadi Fransisco (1980-) Gulyás Gabriella (1985-) (agrár) Ozsváth Xénia Erika Czeglédi Levente (1977-) (agrármérnök)
Pályázati támogatás:TKP2020-NKA-04
Egyéb
ÚNKP20-4-I-DE-101
Egyéb
K139021
OTKA
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM118839
035-os BibID:(cikkazonosító)4387 (Scopus)85185693265
Első szerző:Lugata, James Kachungwa (Ph.D hallgató)
Cím:In ovo feeding of methionine affects antioxidant status and growth-related gene expression of TETRA SL and Hungarian indigenous chicks / James K. Lugata, Sawadi F. Ndunguru, Gebrehaweria K. Reda, Gabriella Gulyás, Renáta Knop, János Oláh, Levente Czeglédi, Csaba Szabó
Dátum:2024
ISSN:2045-2322
Megjegyzések:Methionine (Met) plays a substantial role in poultry due to its involvement in several pathways, including enhancing antioxidant status and improving growth performance and health status. This study examined how in ovo feeding of Met affects hatching performance, antioxidant status, and hepatic gene expression related to growth and immunity in the TETRA-SL LL hybrid (TSL) commercial layer and Hungarian partridge colored hen (HPC) indigenous genotypes. The eggs were injected with saline, DL-Met, and L-Met on 17.5 days of embryonic development. The results showed that the in ovo feeding of DL-Met significantly increased the hatching weight and ferric reducing the ability of the plasma (FRAP) compared with L-Met. The in ovo feeding of either Met source enhanced the liver health and function and hepatic antioxidant status of the chicks. The genotype`s differences were significant; the TSL genotype had better hatching weight, an antioxidant defense system, and downregulated growth-related gene expression than the HPC genotype. In ovo feeding of either Met source enhanced the chicks' health status and antioxidant status, and DL-Met improved the hatching weight of the chicks more than L-Met. Genotype differences were significantly evident in the responses of growth performance, antioxidant status, blood biochemical parameters, and gene expression to Met sources.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 14 : 1 (2024), p. 1-14. -
További szerzők:Ndunguru, Sawadi Fransisco (1980-) Reda, Gebrehaweria Kidane (Phd hallgató) Gulyás Gabriella (1985-) (agrár) Knop Renáta (1983-) (állatorvos) Oláh János (1976-) (állattenyésztés) Czeglédi Levente (1977-) (agrármérnök) Szabó Csaba (1968-) (agrármérnök)
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM118530
035-os BibID:(WoS)001175647600001 (Scopus)85184758825
Első szerző:Lugata, James Kachungwa (Ph.D hallgató)
Cím:Methionine sources and genotype affect embryonic intestinal development, antioxidants, tight junctions, and growth-related gene expression in chickens / James K. Lugata, Sawadi F. Ndunguru, Gebrehaweria K. Reda, Xenia E. Ozsváth, Eszter Angyal, Levente Czegledi, Gabriella Gulyas, Renata Knop, Janos Oláh, Zoltan Mészár, Rita Varga, Brigitta Csernus, Csaba Szabo
Dátum:2024
ISSN:2405-6545
Megjegyzések:Methionine (Met) is an essential and first limiting amino acid in the poultry diet that plays a significant role in chicken embryonic development and growth. The present study examined the effect of in ovo injection of DL-Met and L-Met sources and genotypes on chicken embryonic-intestinal development and health. Fertilized eggs of the two genotypes, TETRA -SL layer hybrid (TSL) d commercial layer hybrid and Hungarian Partridge colored hen breed (HPC) d a native genotype, were randomly distributed into four treatments for each genotype. The treatment groups include the following: 1) control non-injected eggs (NoIn); 2) saline-injected (SaIn); 3) DL-Met injected (DLM); and 4) L-Met injected (LM). The in ovo injection was carried out on 17.5 d of embryonic development; after hatching, eight chicks per group were sacrificed, and the jejunum was extracted for analysis. The results showed that both DLM and LM groups had enhanced intestinal development as evidenced by increased villus width, villus height, and villus area (P < 0.05) compared to the control. The DLM group had significantly reduced crypt depth, glutathione content (GSH), glutathione S-transferase 3 alpha (GST3), occludin (OCLN) gene expression and increased villus height to crypt depth ratio in the TSL genotype than the LM group (P < 0.05). The HPC genotype has overexpressed insulin -like growth factor 1 (IGF1) gene, tricellulin (MD2), occludin (OCLN), superoxide dismutase 1 (SOD1), and GST3 genes than the TSL genotype (P < 0.05). In conclusion, these findings showed that in ovo injection of Met enhanced intestinal development, and function, with genotypes responding differently under normal conditions. Genotypes also influenced the expression of intestinal antioxidants, tight junction, and growth-related genes.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
DL-Methionine
L-Methionine
In ovo injection
Intestinal development
Poultry
Megjelenés:Animal Nutrition. - 16 (2024), p. 218-230. -
További szerzők:Ndunguru, Sawadi Fransisco (1980-) Reda, Gebrehaweria Kidane (Phd hallgató) Ozsváth Xénia Erika Angyal Eszter Czeglédi Levente (1977-) (agrármérnök) Gulyás Gabriella (1985-) (agrár) Knop Renáta (1983-) (állatorvos) Oláh János (1976-) (állattenyésztés) Mészár Zoltán Mihály (1977-) (agrármérnök) Varga Rita Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Szabó Csaba (1968-) (agrármérnök)
Pályázati támogatás:K 139021
Egyéb
Stipendium Hungaricum Scholarship
Egyéb
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM106312
Első szerző:Lugata, James Kachungwa (Ph.D hallgató)
Cím:Effect of genotype on the hematological parameter of TETRA-SL and Hungarian Partridge coloured chickens at young age / James Kachungwa Lugata, Xénia Erika Ozsváth, Sawadi Fransisco Ndunguru, Gebrehewaria Reda Kidane, Renáta Knop, Eszter Angyal, János Oláh, Csaba Szabó
Dátum:2022
ISSN:1587-1282
Megjegyzések:Indigenous chickens are well known for their dual-purpose function and palatable meat. However, the information on their hematology parameters is lacking and hence hampering the poultry industry production of local breeds. The main objective of this study was to examine the hematological parameters of Hungarian Partridge Coloured hen (HPC) and TETRA-SL (TSL) genotype and determine the hematological reference interval values. This trial was part of the larger experiment where a total of 200 chicks (HPC + TSL) were reared. For this trial the blood samples were obtained from brachial wing veins of 8 chicks of each genotype for blood hematological analysis. The results indicated that some of the hematological parameters such as red blood cells-RBC, white blood cells-WBC, hemoglobin-Hb, hematocrit-Ht, platelets-Plt, lymphocytes-LYM, and granulocytes-GRAN were significantly affected by the genotypes (p < 0.05). The genotype did not affect the mean corpuscular volume-MCV, mean corpuscular hemoglobin-MCH, mean corpuscular hemoglobin concentration-MCHC, and GRAN (p > 0.05). The hematological reference interval values were slightly higher in the TSL genotype compared to HPC chicks. It is concluded that genotype has a significant effect on the hematological parameters. The results from this trial will be help and design the baseline reference values for the HPC genotype which will be useful in assessing the health status of these indigenous chickens.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
Hungarian Partridge coloured hen
Hematology parameter
TETRA-SL
Genotype
Megjelenés:Agrártudományi közlemények = Acta agraria Debreceniensis. - 2022 : 1 (2022), p. 99-104. -
További szerzők:Ozsváth Xénia Erika Ndunguru, Sawadi Fransisco (1980-) Reda, Gebrehaweria Kidane (Phd hallgató) Knop Renáta (1983-) (állatorvos) Angyal Eszter Oláh János (1976-) (állattenyésztés) Szabó Csaba (1968-) (agrármérnök)
Pályázati támogatás:EFOP-362-16-2017-00001
EFOP
EFOP-3.6.3-VEKOP-16-2017-00008
EFOP-VEKOP
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM119806
Első szerző:Ndunguru, Sawadi Fransisco (1980-)
Cím:Embryonic methionine triggers post-natal developmental programming in Japanese quail / Ndunguru, Sawadi F.; Reda, Gebrehaweria K.; Csernus, Brigitta; Knop, Renáta; Gulyás, Gabriella; Szabó, Csaba; Czeglédi, Levente; Lendvai, Ádám Z.
Dátum:2024
ISSN:0174-1578
Megjegyzések:Embryonic development is one of the most sensitive and critical stages when maternal effects may influence the offspring's phenotype. In birds and other oviparous species, embryonic development is confined to the eggs, therefore females must deposit resources into the eggs to prepare the offspring for the prevailing post-natal conditions. However, the mechanisms of such phenotypic adjustments remain poorly understood. We simulated a maternal nutritional transfer by injecting 1 mg of l-methionine solution into Japanese quail eggs before the onset of incubation. The increase in early methionine concentration in eggs activated the insulin/insulin-like signalling and mechanistic target of rapamycin (IIS/mTOR) signalling pathways and affected post-natal developmental trajectories. Chicks from methionine-supplemented eggs had higher expression of liver IGF1 and mTOR genes at hatching but were similar in size, and the phenotypic effects of increased growth became apparent only a week later and remained up to three weeks. Circulating levels of insulin-like growth factor-1 (IGF-1) and expression of ribosomal protein serine 6 kinase 1 (RPS6K1), the mTOR downstream effector, were elevated only three weeks after hatching. These results show that specific nutritional cues may have phenotypic programming effects by sequentially activating specific nutrient-sensing pathways and achieving transgenerational phenotypic plasticity.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
L-methionine
IGF1
mTOR
Growth
Amino acid
Megjelenés:Journal Of Comparative Physiology B-Biochemical Systemic And Environmental Physiology. - Epub (2024), p. 1-11. -
További szerzők:Reda, Gebrehaweria Kidane (Phd hallgató) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Knop Renáta (1983-) (állatorvos) Gulyás Gabriella (1985-) (agrár) Szabó Csaba (1968-) (agrármérnök) Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:K139021
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM118739
Első szerző:Ndunguru, Sawadi Fransisco (1980-)
Cím:The prenatal window: Influence of leucine on growth and development of Japanese quail / Ndunguru Sawadi F., Reda Gebrehaweria K., Csernus Brigitta, Szabó Csaba, Lendvai Ádám Z., Czeglédi Levente
Dátum:2024
Megjegyzések:Nutrients acquired during embryonic developmental stages entail part of the adult energy budget. The crucial time is during the perinatal period in birds when embryos absorb residual yolk prehatch and during the first few days of post-hatch. During this fragile period, intestinal and skeletal development occurs expeditiously, and chicks experience a significant physiological shift. We collected freshly laid Japanese quail (Coturnix japonica) eggs, weighed them, and then incubated them under standard conditions. We injected 2.5 mg/egg of leucine amino acid solution the tenth day after incubation, and the second group was injected with a physiological saline solution to serve as a control. Leucine treatment increased the hatching success and grew faster with increased body mass, and influenced the increase of wing, head, tarsal length, and gastrointestinal development more than the control from 5-days old chicks, tarsal length 3-days old chicks and wing length from 7-days old chicks consistently up to 21-days old than the control. Leucine did not influence the gastrointestinal development of day-old chicks but increased gastrointestinal development in 21-day-old chicks with significant interaction between treatment and age of chicks. In Ovo, leucine supplementation improved growth and development and enhanced hormonal expression. The adaptive changes in hormonal expression stored lifetime nutritional memory of early dietary experience, which improved growth and development essential for increasing production efficiency.
ISBN:978-615-6457-43-1
Tárgyszavak:Agrártudományok Állattenyésztési tudományok előadáskivonat
könyvrészlet
Amino acid
growth
Japanese quail
Megjelenés:II. Magyar Agrártudományi Doktoranduszok Szimpóziuma : Absztraktkötet / szerk. Hajdú Péter. - p. 25. -
További szerzők:Reda, Gebrehaweria Kidane (Phd hallgató) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Szabó Csaba (1968-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus) Czeglédi Levente (1977-) (agrármérnök)
Pályázati támogatás:K139021
OTKA
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM120449
Első szerző:Reda, Gebrehaweria Kidane (Phd hallgató)
Cím:Expression of nutrient sensing genes mediate the effect of dietary unpredictability in Japanese quails / Reda Gebrehaweria K., Ndunguru Sawadi F., Csernus Brigitta, Szabó Csaba, Czeglédi Levente, Lendvai Ádám Z.
Dátum:2024
Megjegyzések:Dietary fluctuation is a common phenomenon in an organism's life and can compel them to change their mechanisms for growth, reproduction, immunity, and lifespan. These fluctuations hold evolutionary significance as they prompt diverse physiological and behavioural responses. Understanding animals' molecular mechanisms of adaptation to unpredictable changes in dietary availability is an essential question in animal research. Previous studies have proposed that one such signalling pathway, nutrient-sensing pathway, mediates systemic and cellular nutritional status hence regulates growth, reproduction and healthspan. Our previous study into varying degrees of dietary restriction in Japanese quails revealed significant changes in expression of nutrient sensing genes. To explore this further, we designed a study involved a combination of predictable feeding (control or 40% restricted feeding) and daily unpredictable feeding to Japanese quails, aimed to discern if unpredictable feed supply influence gene expression and fitness variables differently compared to control and consistently restricted birds. The research involved housing quails individually for 16 days and monitoring gene expression, body weight, egg laying, and egg morphology. Results revealed intriguing findings. Unpredictable feeding reduced body weight significantly in females but not in males, while a 40% dietary restriction lowered body weight in both sexes. However, only the 40% restriction notably affected egg laying and egg morphology. Gene expression analysis showed distinct patterns in nutrient-sensing genes. In the female groups, there was a notable reduction in the expression of insulin-like growth factor-1 and mechanistic target of rapamycin genes in both the unpredictable and restricted groups. Conversely, Forkhead box O1, Unc-51-like autophagy-activating kinases, autophagy genes (ATG9A and ATG5) and, unexpectedly, ribosomal protein S6 kinase 1 displayed an increasing trend in the constantly restricted and/or unpredictably fed groups. In males, all genes showed no significant variation although the trend mirrors what is observed in females. This study sheds light on how unpredictable dietary fluctuations impact gene expression and fitness traits. It also uncovers sex-specific variations in response to dietary changes.
ISBN:978-615-6457-43-1
Tárgyszavak:Agrártudományok Állattenyésztési tudományok előadáskivonat
könyvrészlet
Gene expression
Japanese quail
nutrient sensing pathway
unpredictable feeding
Megjelenés:II. Magyar Agrártudományi Doktoranduszok Szimpóziuma / szerk. Hajdú Péter. - p. 27. -
További szerzők:Ndunguru, Sawadi Fransisco (1980-) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Szabó Csaba (1968-) (agrármérnök) Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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8.

001-es BibID:BIBFORM120370
Első szerző:Reda, Gebrehaweria Kidane (Phd hallgató)
Cím:Dietary restriction reveals sex-specifc expression of the mTOR pathway genes in Japanese quails / Gebrehaweria K. Reda, Sawadi F. Ndunguru, Brigitta Csernus, Renáta Knop, James K. Lugata, Csaba Szabó, Levente Czeglédi, Ádám Z. Lendvai
Dátum:2024
ISSN:2045-2322
Megjegyzések:Limited resources affect an organism's physiology through the conserved metabolic pathway, the mechanistic target of rapamycin (mTOR). Males and females often react differently to nutritional limitation, but whether it leads to differential mTOR pathway expression remains unknown. Recently, we found that dietary restriction (DR) induced significant changes in the expression of mTOR pathway genes in female Japanese quails (Coturnix japonica). We simultaneously exposed 32 male and female Japanese quails to either 20%, 30%, 40% restriction or ad libitum feeding for 14 days and determined the expression of six key genes of the mTOR pathway in the liver to investigate sex differences in the expression patterns. We found that DR significantly reduced body mass, albeit the effect was milder in males compared to females. We observed sex-specific liver gene expression. DR downregulated mTOR expression more in females than in males. Under moderate DR, ATG9A and RPS6K1 expressions were increased more in males than in females. Like females, body mass in males was correlated positively with mTOR and IGF1, but negatively with ATG9A and RS6K1 expressions. Our findings highlight that sexes may cope with nutritional deficits differently and emphasise the importance of considering sexual differences in studies of dietary restriction.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 14 : 1 (2024), p. 1-14. -
További szerzők:Ndunguru, Sawadi Fransisco (1980-) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Knop Renáta (1983-) (állatorvos) Lugata, James Kachungwa (1992-) (Ph.D hallgató) Szabó Csaba (1968-) (agrármérnök) Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:K139021
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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