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001-es BibID:	BIBFORM099414
035-os BibID:	(cikkazonosító)115590
Első szerző:	Sanna, Daniele (vegyész)
Cím:	Interaction of V(V) complexes formed by picolinic and pyrazinecarboxylic acid derivatives with red blood cells / Daniele Sanna, Péter Buglyó, Sándor Nagy, Franc Perdih, Jessica Palomba, Valeria Ugone, Eugenio Garribba
Dátum:	2022
ISSN:	0277-5387
Megjegyzések:	The interaction with red blood cells (RBC) of vanadium(V) complexes formed by 3,5-difluoropicolinic acid (HpicFF), 3-hydroxypicolinic acid (H2hypic) and pyrazinecarboxylic acid (Hprz) has been examined. Electron Paramagnetic Resonance (EPR) spectroscopy results suggest that V(V) is reduced in all cases to V(IV) inside the erythrocytes. The thermodynamic stability of V(V) and corresponding V(IV) complexes has been related with the species detected in the cellular environment; when the ligands form unstable complexes with both VVO2+and VIVO2+ions (picFF and prz), the species formed inside RBC are similar to those observed when starting with vanadate(V) alone, that is VIVO2+? formed upon V(V) reduction ? which distributes among the cellular bio-ligands forming different types of complexes. When in the ligand molecule other groups able to form chelated complexes are present (H2hypic), more stable species are formed inside the RBC. The amount of complex able to enter the RBC depends on the ligand structure which could influence the metal uptake. The interaction of different VIVO2+complexes formed by picolinate (picFF, pic =picolinate, picCN =5-cyanopicolinate) and pyrazinecarboxylate (prz and przNH2 =3-aminopyrazine-2-carboxylate) derivatives with hemoglobin (Hb), which is the main candidate to bind the VIVO2+ion in the cytosol, was also investigated to rationalize the results. The ligands which form at physiological pH relatively stable complexes with VIVO2+(przNH2 and pic) can give inside the erythrocytes mixed species after the replacement of an equatorial water molecule by an imidazole nitrogen of a histidine residue of the protein, while the ligands which form with VIVO2+unstable complexes (picCN, picFF, prz) yield the same species observed in the binary system VIVO2+?Hb.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk vanádium komplex
Megjelenés:	Polyhedron. - 212 (2022), p. 1-7. -
További szerzők:	Buglyó Péter (1965-) (vegyész) Nagy Sándor (1993-) (vegyész) Perdih, Franc Palomba, Jessica Ugone, Valeria Garribba, Eugenio
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM099410
Első szerző:	Sanna, Daniele (vegyész)
Cím:	Speciation in aqueous solution and interaction with low and high molecular mass blood bioligands of [V IV O(oda)(H 2 O) 2 ], a V compound with in vitro anticancer activity / Daniele Sanna, Valeria Ugone, Péter Buglyó, Sándor Nagy, István Kacsir, Eugenio Garribba
Dátum:	2018
ISSN:	0020-1693
Megjegyzések:	In this work the speciation in aqueous solution of the compound [VIVO(oda)(H2O)2], where oda is oxydiacetate dianion (OOCCH2)2O, which shows in vitro anticancer activity, was studied. Its interaction with the two serum bioligands with highest affinity for VIV, lactic (Hlact) and citric (H3citr) acid, and with the two proteins candidate to participate to the transport of VIVO compounds in the organism, transferrin (hTf) and albumin (HSA), was also examined. The study was carried out with the combined application of spectroscopic (Electron Paramagnetic Resonance, EPR), analytical (pH-potentiometry) and computational (Density Functional Theory, DFT) methods. The results showed that in aqueous solution [VO(oda)(H2O)2] undergoes hydrolysis above pH 4-5 with formation of the EPR-active species [(VO)2(oda)2(OH)2]2- around pH 6 and of [(VO)2(OH)5]- at physiological pH. DFT calculations suggested that the most stable isomers of 1:1 species are the hexa-coordinated OC-6-23 with a mer arrangement of oda - similar to that observed in the solid state - and the penta-coordinated SPY-5-14, whereas for 1:2 species the fac arrangement of oda is favored. Citrate is able to displace completely the oda ligand in [VO(oda)(H2O)2] and only the dinuclear species [(VO)2(citrH-1)2]4- was detected at pH 7.4, while with lactate the formation of a mixed complex VIVO-oda-lact was observed. [VO(oda)(H2O)2] interacts with apo-transferrin forming a mixed complex (VO)(hTf)(oda) where vanadium is bound in the iron sites and oda behaves as a synergistic anion, while with albumin no interaction was revealed. Model calculations suggest that when [VO(oda)(H2O)2] is administered orally (concentration ca. 1-10?M) or by injection (concentration approximately in the range 10-100?M), (VO)(hTf) and (VO)2(hTf) should be formed; these species could reach the target organs and be recognized by the hTf receptors of the cells, favoring the vanadium uptake.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk vanádium
Megjelenés:	Inorganica Chimica Acta. - 472 (2018), p. 127-138. -
További szerzők:	Ugone, Valeria Buglyó Péter (1965-) (vegyész) Nagy Sándor (1993-) (vegyész) Kacsir István (1994-) (vegyész) Garribba, Eugenio
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: