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1.

001-es BibID:BIBFORM078704
Első szerző:Buglyó Péter (vegyész)
Cím:Tuning the redox potentials of ternary cobalt(III) complexes containing various hydroxamates / Buglyó Péter, Kacsir István, Kozsup Máté, Nagy Imre, Nagy Sándor, Bényei Attila Csaba, Kováts Éva, Farkas Etelka
Dátum:2018
ISSN:0020-1693
Megjegyzések:Sixteen cobalt(III) complexes incorporating one of the investigated 4N donor tripodal amines in the presence or absence of differently substituted hydroxamates have been synthesized and the effect of the nature of the N-donor, size of the chelates formed and the effect of the type of the substituent(s) at the hydroxamate moiety on the redox properties of the complexes have been studied. The crystal and molecular structures of the new complexes, [Co(unspenp)(H2O)Cl]Cl2.H2O (4), [Co(tren)(phebha)](ClO4)2 (11), [Co(tpa)(bha)](ClO4)2?C2H5OH?H2O (15) and [Co(tpa)(phebha)](ClO4)2 (16) have also been determined by single crystal X-ray diffraction method. Cyclic voltammetric (CV) results indicated the irreversible reduction of Co(III) in all the investigated complexes. Out of the four studied tripodal amines, abap was found to decrease the Co(III/II) reduction potential far below the region of bioreductants. Decreasing of two of the chains by one CH2 in tren compared to abap resulted in less negative reduction potential of the corresponding complex. Further positive shift was observed by introducing two (uns-penp), and especially three (tpa) ?-back-bonding pyridyl rings into the chains of tetramines. In agreement with literature results, the 3+ oxidation state of the central cobalt ion was found to be extremely stabilized in the ternary complexes containing the doubly deprotonated benzohydroximate, but the metal ion is significantly more reducible in the ternary complexes with mono-deprotonated benzohydroxamate/derivative ligands. Measurable effect was not found on the redox potential via introduction of chloro or nitro substituents in para position into the phenyl moiety of bha? (Cl-bha? and NO2-bha? ). Significant positive shift (ca. 200 mV) was obtained, however, when RN = H was replaced by a phenyl ring in phebha? therefore complexes with this latter ligand can be likely candidates for the in vitro releasing of hydroxamates with proven biological activity.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Inorganica Chimica Acta. - 472 (2018), p. 234-242. -
További szerzők:Kacsir István (1994-) (vegyész) Kozsup Máté (1992-) (Okleveles vegyész) Nagy Imre (1992-) (vegyész analitikus) Nagy Sándor (1993-) (vegyész) Bényei Attila (1962-) (vegyész) Kováts Éva (1977-) (vegyész) Farkas Etelka (1948-) (vegyész)
Pályázati támogatás:GINOP-2.3.2-15-2016-00008
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OTKA-112317
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2.

001-es BibID:BIBFORM089448
Első szerző:Crlikova, Hana
Cím:Antiproliferative, DNA binding, and cleavage properties of dinuclear Co(III) complexes containing the bioactive quinizarin ligand / Hana Crlikova, Hana Kostrhunova, Jitka Pracharova, Máté Kozsup, Sándor Nagy, Péter Buglyó, Viktor Brabec,Jana Kasparkova
Dátum:2020
ISSN:0949-8257
Megjegyzések:The adverse side efects and acquired resistance associated with the clinical application of traditional platinum-based anticancer drugs have forced investigation of alternative transition metal-based compounds and their cytostatic properties. Over the last years, the anticancer potential of cobalt complexes has been extensively studied, and in-depth analyses of their mode of action have been conducted. In this work, we present antiproliferative activity against human cancer cells of the dinuclear Co(III) complexes bearing the quinizarin ligand and tris(2aminoethyl)amine (tren, compound 1) or tris(2-pyridylmethyl)amine (tpa, compound 2) co-ligands. To contribute the understanding mechanisms of biological action of these compounds, their association with DNA in the cells, DNA binding in cell-free media, and DNA cleavage capability were investigated in detail. The results demonstrate that both complexes interact with DNA in tumor cells. However, their mechanism of antiproliferative action is diferent, and this diference is mirrored by distinct antiproliferative activity. The antiproliferative efect of 1 is connected with its ability to intercalate into DNA and subsequently to inhibit activities of DNA processing enzymes. In contrast, the total antiproliferative efciency of 2, thanks to its redox properties, appears to be connected with its ability to form radicals and, consequently, with the ability of 2 to cleave DNA. Hence, the fndings presented in this study may signifcantly contribute to understanding the antitumor potential of cobalt complexes.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Biological Inorganic Chemistry. - 25 : 2 (2020), p. 339-350. -
További szerzők:Kostrhunova, Hana Pracharova, Jitka Kozsup Máté (1992-) (Okleveles vegyész) Nagy Sándor (1993-) (vegyész) Buglyó Péter (1965-) (vegyész) Brabec, Viktor Kasparkova, Jana
Pályázati támogatás:GINOP-2.3.2-15-2016-00008
GINOP
OTKA-112317
OTKA
ÚNKP-19-3-I-DE-45
Egyéb
ÚNKP-19-3-I-DE-56
Egyéb
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM089447
035-os BibID:(cikkazonosító)110963 (WoS)000528628200017 (Scopus)85076831661
Első szerző:Kozsup Máté (Okleveles vegyész)
Cím:Synthesis, characterization and albumin binding capabilities of quinizarin containing ternary cobalt(III) complexes / Kozsup Máté, Dömötör Orsolya, Nagy Sándor, Farkas Etelka, Enyedy Éva A., Buglyó Péter
Dátum:2020
ISSN:0162-0134 1873-3344
Megjegyzések:Four Co(III) ternary complexes with the composition of [(Co(4 N))2(quin)](ClO4)4 or [(Co(4 N))2(quinS)](ClO4)3, where 4 N =tris(2aminoethyl)amine (tren) or tris(2-pyridylmethyl)amine (tpa), quinH2 = quinizarin (1,4-dihydroxy-9,10-anthraquinone), quinSH3 = quinizarin-2-sulfonic acid (1,4-dihydroxy-9,10-anthraquinone2-sulfonic acid), were synthesized, characterized and their human serum albumin (HSA) binding capabilities were also tested. The complexes can be considered as likely chaperons of quinizarins which are structural models for anthracycline-based anticancer drugs like doxorubicin. All the Co(III) complexes are dinuclear and were isolated as mixture of isomers. Comparison of the cyclic voltammograms of the free ligands and the appropriate Co(III) complexes revealed that the new signals belonging to reversible processes in the range ?400?0 mV (vs. Ag/AgCl) for the complexes can be attributed to the reversible reduction of the Co(III) centre. These potentials are in the range of typical (O,O) chelated Co(III) ternary complexes bearing 4 N donor ligands and follow the order being more positive for the tpa containing complexes. Presence of the sulfonate group in the quinizarin results in slightly more negative reduction potential of the Co(III) complexes. HSA binding capabilities of the quinH2 and quinSH3 ligands as well as the appropriate complexes showed that quinSH3 has higher affinity to the protein than quinH2 while none of the complexes seem to bind to HSA.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Inorganic Biochemistry. - 204 (2020), p. 1-9. -
További szerzők:Dömötör Orsolya Nagy Sándor (1993-) (vegyész) Farkas Etelka (1948-) (vegyész) Enyedy Éva Anna (1975-) (vegyész) Buglyó Péter (1965-) (vegyész)
Pályázati támogatás:GINOP-2.3.2-15-2016-00008
GINOP
OTKA-112317
OTKA
Egyéb
GINOP
ÚNKP19-3-I-DE-45
Egyéb
ÚNKP19-3-I-DE-56
Egyéb
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM099415
035-os BibID:(cikkazonosító)3586 (WoS)000666566100001 (Scopus)85108329799
Első szerző:Nagy Sándor (vegyész)
Cím:Donor Atom Preference of Organoruthenium and Organorhodium Cations on the Interaction with Novel Ambidentate (N,N) and (O,O) Chelating Ligands in Aqueous Solution / Nagy Sándor, Ozsváth András, Bényei Attila Cs., Farkas Etelka, Buglyó Péter
Dátum:2021
ISSN:1420-3049
Megjegyzések:Two novel, pyridinone-based chelating ligands containing separated (O,O) and (Namino,Nhet) chelating sets (Namino = secondary amine; Nhet = pyrrole N for H(L3) (1-(3-(((1H-pyrrole-2-yl)methyl)-amino)propyl)-3-hydroxy-2-methylpyridin-4(1H)-one) or pyridine N for H(L5) (3-hydroxy-2-methyl-1-(3-((pyridin-2-ylmethyl)amino)propyl)pyridin-4(1H)-one)) were synthesized via reduction of the appropriate imines. Their proton dissociation processes were explored, and the molecular structures of two synthons were assessed by X-ray crystallography. These ambidentate chelating ligands are intended to develop Co(III)/PGM (PGM = platinum group metal) heterobimetallic multitargeted complexes with anticancer potential. To explore their metal ion binding ability, the interaction with Pd(II), [(?6-p-cym)Ru]2+ and [(?5-Cp*)Rh]2+ (p-cym = 1-methyl-4-isopropylbenzene, Cp* = pentamethyl-cyclopentadienyl anion) cations was studied in aqueous solution with the combined use of pH-potentiometry, NMR and HR ESI-MS. In general, organorhodium was found to form more labile complexes over ruthenium, while complexation of the (N,N) chelating set was slower than the processes of the pyridinone unit with (O,O) coordination. Formation of the organoruthenium complexes starts at lower pH (higher thermodynamic stabilities of the corresponding complexes) than for [(?5-Cp*)Rh]2+ but, due to the higher affinity of [?6-p-cym)Ru]2+ towards hydrolysis, the complexed ligands are capable of competing with hydroxide ion in a lesser extent than for the rhodium systems. As a result, under biologically relevant conditions, the rhodium binding effectivity of the ligands becomes comparable or even slightly higher than their effectivity towards ruthenium. Our results indicate that H(L3) is a less efficient (N,N) chelator for these metal ions than H(L5). Similarly, due to the relative effectivity of the (O,O) and (N,N) chelates at a 1:1 metal-ion-to-ligand ratio, H(L5) coordinates in a (N,N) manner to both cations in the whole pH range studied while, for H(L3), the complexation starts with (O,O) coordination. At a 2:1 metal-ion-to-ligand ratio, H(L3) cannot hinder the intensive hydrolysis of the second metal ion, although a small amount of 2:1 complex with [(?5-Cp*)Rh]2+ can also be detected.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
ruténium
ródium
komplex
piridinon
maltol
Megjelenés:Molecules. - 26 : 12 (2021), p. 1-23. -
További szerzők:Ozsváth András (1992-) (vegyész) Bényei Attila (1962-) (vegyész) Farkas Etelka (1948-) (vegyész) Buglyó Péter (1965-) (vegyész)
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5.

001-es BibID:BIBFORM096865
035-os BibID:(cikkazonosító)111372 (WoS)000651369100004 (Scopus)85105285700
Első szerző:Nagy Sándor (vegyész)
Cím:Effect of the replacement of tripodal 4N donors by two 2N chelators on the redox and cytotoxic activity of maltolato and deferipronato containing Co(III) complexes / Nagy Sándor, Tóth Emese, Kacsir István, Makai Attila, Bényei Attila Csaba, Buglyó Péter
Dátum:2021
ISSN:0162-0134 1873-3344
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Inorganic Biochemistry. - 220 (2021), p. 1-10. -
További szerzők:Tóth Emese (1988-) (biotechnológus) Kacsir István (1994-) (vegyész) Makai Attila Bényei Attila (1962-) (vegyész) Buglyó Péter (1965-) (vegyész)
Pályázati támogatás:GINOP-2.3.2-15-2016-00008
GINOP
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Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM099414
035-os BibID:(cikkazonosító)115590
Első szerző:Sanna, Daniele (vegyész)
Cím:Interaction of V(V) complexes formed by picolinic and pyrazinecarboxylic acid derivatives with red blood cells / Daniele Sanna, Péter Buglyó, Sándor Nagy, Franc Perdih, Jessica Palomba, Valeria Ugone, Eugenio Garribba
Dátum:2022
ISSN:0277-5387
Megjegyzések:The interaction with red blood cells (RBC) of vanadium(V) complexes formed by 3,5-difluoropicolinic acid (HpicFF), 3-hydroxypicolinic acid (H2hypic) and pyrazinecarboxylic acid (Hprz) has been examined. Electron Paramagnetic Resonance (EPR) spectroscopy results suggest that V(V) is reduced in all cases to V(IV) inside the erythrocytes. The thermodynamic stability of V(V) and corresponding V(IV) complexes has been related with the species detected in the cellular environment; when the ligands form unstable complexes with both VVO2+and VIVO2+ions (picFF and prz), the species formed inside RBC are similar to those observed when starting with vanadate(V) alone, that is VIVO2+? formed upon V(V) reduction ? which distributes among the cellular bio-ligands forming different types of complexes. When in the ligand molecule other groups able to form chelated complexes are present (H2hypic), more stable species are formed inside the RBC. The amount of complex able to enter the RBC depends on the ligand structure which could influence the metal uptake. The interaction of different VIVO2+complexes formed by picolinate (picFF, pic =picolinate, picCN =5-cyanopicolinate) and pyrazinecarboxylate (prz and przNH2 =3-aminopyrazine-2-carboxylate) derivatives with hemoglobin (Hb), which is the main candidate to bind the VIVO2+ion in the cytosol, was also investigated to rationalize the results. The ligands which form at physiological pH relatively stable complexes with VIVO2+(przNH2 and pic) can give inside the erythrocytes mixed species after the replacement of an equatorial water molecule by an imidazole nitrogen of a histidine residue of the protein, while the ligands which form with VIVO2+unstable complexes (picCN, picFF, prz) yield the same species observed in the binary system VIVO2+?Hb.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
vanádium
komplex
Megjelenés:Polyhedron. - 212 (2022), p. 1-7. -
További szerzők:Buglyó Péter (1965-) (vegyész) Nagy Sándor (1993-) (vegyész) Perdih, Franc Palomba, Jessica Ugone, Valeria Garribba, Eugenio
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Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM099412
035-os BibID:(WoS)000457067600018 (Scopus)85060548886
Első szerző:Sanna, Daniele (vegyész)
Cím:Role of Ligands in the Uptake and Reduction of V(V) Complexes in Red Blood Cells / Daniele Sanna, Jessica Palomba, Giuseppe Lubinu, Péter Buglyó, Sándor Nagy, Franc Perdih, Eugenio Garribba
Dátum:2018
ISSN:0022-2623 1520-4804
Megjegyzések:The interaction with erythrocytes of four [(VO2L2)-O-V](-) complexes, with L = picolinate (pic), 5-cyanopicolinate (picCN), 3-aminopyrazine-2-carboxylate (przNH(2)), and 1,2-dimethyl-3-hydroxy-4(1H)-pyridinonate (dhp), was studied. The thermodynamic stability at physiological pH is: [(VO2)-O-V(dhp)(2)](-) > [(VO2)-O-V(przNH(2))(2)](-) > [VVO2(pic)(2)](-) > [VVO2(picCN)(2)](-). With picCN and pic, V exists at physiological pH as (H2VO4-)-O-V, with przNH(2) as a mixture of (H2VO4-)-O-V and [VVO2(przNH(2))(2)](-) and with dhp as [VVO2(dhp)(2)](-). In the systems with pic and picCN, (H2VO4-)-O-V and the ligands cross the erythrocyte membrane independently, with dhp the uptake occurs by diffusion, whereas with przNH(2) both the mechanisms are active. Inside erythrocytes stable (VOL2)-O-IV complexes are formed, indicating that there is no relationship with the stability and redox state of the administered compounds and that, if the metal ion changes its oxidation state in the cytosol as V does, unstable complexes in the extracellular medium could become stable inside the cells and contribute to the pharmacological action.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
vanádium
Megjelenés:Journal Of Medicinal Chemistry. - 62 : 2 (2018), p. 654-664. -
További szerzők:Palomba, Jessica Lubinu, Giuseppe Buglyó Péter (1965-) (vegyész) Nagy Sándor (1993-) (vegyész) Perdih, Franc Garribba, Eugenio
Pályázati támogatás:GINOP-2.3.2-15-2016-00008
GINOP
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8.

001-es BibID:BIBFORM099410
Első szerző:Sanna, Daniele (vegyész)
Cím:Speciation in aqueous solution and interaction with low and high molecular mass blood bioligands of [V IV O(oda)(H 2 O) 2 ], a V compound with in vitro anticancer activity / Daniele Sanna, Valeria Ugone, Péter Buglyó, Sándor Nagy, István Kacsir, Eugenio Garribba
Dátum:2018
ISSN:0020-1693
Megjegyzések:In this work the speciation in aqueous solution of the compound [VIVO(oda)(H2O)2], where oda is oxydiacetate dianion (OOCCH2)2O, which shows in vitro anticancer activity, was studied. Its interaction with the two serum bioligands with highest affinity for VIV, lactic (Hlact) and citric (H3citr) acid, and with the two proteins candidate to participate to the transport of VIVO compounds in the organism, transferrin (hTf) and albumin (HSA), was also examined. The study was carried out with the combined application of spectroscopic (Electron Paramagnetic Resonance, EPR), analytical (pH-potentiometry) and computational (Density Functional Theory, DFT) methods. The results showed that in aqueous solution [VO(oda)(H2O)2] undergoes hydrolysis above pH 4-5 with formation of the EPR-active species [(VO)2(oda)2(OH)2]2- around pH 6 and of [(VO)2(OH)5]- at physiological pH. DFT calculations suggested that the most stable isomers of 1:1 species are the hexa-coordinated OC-6-23 with a mer arrangement of oda - similar to that observed in the solid state - and the penta-coordinated SPY-5-14, whereas for 1:2 species the fac arrangement of oda is favored. Citrate is able to displace completely the oda ligand in [VO(oda)(H2O)2] and only the dinuclear species [(VO)2(citrH-1)2]4- was detected at pH 7.4, while with lactate the formation of a mixed complex VIVO-oda-lact was observed. [VO(oda)(H2O)2] interacts with apo-transferrin forming a mixed complex (VO)(hTf)(oda) where vanadium is bound in the iron sites and oda behaves as a synergistic anion, while with albumin no interaction was revealed. Model calculations suggest that when [VO(oda)(H2O)2] is administered orally (concentration ca. 1-10?M) or by injection (concentration approximately in the range 10-100?M), (VO)(hTf) and (VO)2(hTf) should be formed; these species could reach the target organs and be recognized by the hTf receptors of the cells, favoring the vanadium uptake.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
vanádium
Megjelenés:Inorganica Chimica Acta. - 472 (2018), p. 127-138. -
További szerzők:Ugone, Valeria Buglyó Péter (1965-) (vegyész) Nagy Sándor (1993-) (vegyész) Kacsir István (1994-) (vegyész) Garribba, Eugenio
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Intézményi repozitóriumban (DEA) tárolt változat
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