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001-es BibID:BIBFORM088388
035-os BibID:(cikkazonosító)7063 (Scopus)85092778560 (WOS)000585101300001
Első szerző:Hajdu Péter (gyorsító üzemeltető mérnök)
Cím:Optimized Size and Distribution of Silver Nanoparticles on the Surface of Titanium Implant Regarding Cell Viability / Hajdu Péter, Lampé István, Rácz Richárd, Biri Sándor, Csík Attila, Tóth Ferenc, Szalóki Melinda, Hegedűs Viktória, Dombrádi Zsuzsanna, Varga István, Csarnovics István, Kökényesi Sándor, Beke Dezső László, Hegedűs Csaba
Dátum:2020
ISSN:2076-3417
Megjegyzések:Though the antibacterial effect is advantageous, silver and silver nanoparticles can negatively affect the viability of human tissues. This study aims to check the viability of cells on surfaces with different particle size and to find the biologically optimal configuration. We investigated the effect of modified thickness of vaporized silver and applied heat and time on the physical characteristics of silver nanoparticle covered titanium surfaces. Samples were examined by scanning electron microscopy, mass spectrometry, and drop shape analyzer. To investigate how different physical surface characteristics influence cell viability, Alamar Blue assay for dental pulp stem cells was carried out. We found that different surface characteristics can be achieved by modifying procedures when creating silver nanoparticle covered titanium. The size of the nanoparticles varied between 60 to 368 nm, and hydrophilicity varied between 63 and 105 degrees of contact angle. Investigations also demonstrated that different physical characteristics are related to a different level of viability. Surfaces covered with 60 nm particle sizes proved to be the most hydrophilic, and the viability of the cells was comparable to the viability measured on the untreated control surface. Physical and biological characteristics of silver nanoparticle covered titanium, including cell viability, have an acceptable level to be used for antibacterial effects to prevent periimplantitis around implants.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
silver nanoparticles
antibacterial effect
periimplantitis
cell viability
Megjelenés:Applied Sciences-Basel. - 10 : 20 (2020), p. 1-13. -
További szerzők:Lampé István (1960-) (fogszakorvos) Rácz Richárd (1985-) (fizikus) Biri Sándor Csik Attila (1975-) (fizikus) Tóth Ferenc (1980-) (molekuláris biológus) Szalóki Melinda (1981-) (vegyész) Hegedűs Viktória (1986-) (fogorvos) Dombrádi Zsuzsanna Rita (1983-) (molekuláris biológus, mikrobiológus) Varga István (1974-) (fogszakorvos) Csarnovics István (1986-) (fizikus) Kökényesi Sándor (1946-) (fizikus) Beke Dezső László (1945-) (fizikus) Hegedűs Csaba (1953-) (fogszakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00011
GINOP
GINOP-2.3.2-15-2016-00022
GINOP
GINOP-2.3.2-15-2016-00041
GINOP
GINOP-2.3.3-15-2016-00029
GINOP
NKFIH-1150-6/2019
NKFIH
Internet cím:Szerző által megadott URL
DOI
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001-es BibID:BIBFORM079731
035-os BibID:(WoS)000473358900002 (Scopus)85069927512
Első szerző:Lampé István (fogszakorvos)
Cím:Investigation of silver nanoparticles on titanium surface created by ion implantation technology / István Lampé, Dezső Beke, Sándor Biri, István Csarnovics, Attila Csik, Zsuzsanna Dombrádi, Péter Hajdu, Viktória Hegedűs, Richárd Rácz, István Varga, Csaba Hegedűs
Dátum:2019
ISSN:1178-2013
Megjegyzések:Objectives: Using dental Ti implants has become a well-accepted and used method for replacing missing dentition. It has become evident that in many cases peri-implant inflammation develops. The objective was to create and evaluate the antibacterial effect of silver nanoparticle (Ag-NP) coated Ti surfaces that can help to prevent such processes if applied on the surface of dental implants. Methods: Annealing I, Ag ion implantation by the beam of an Electron Cyclotron Resonance Ion Source (ECRIS), Ag Physical Vapor Deposition (PVD), Annealing II procedures were used, respectively, to create a safely anchored Ag-NP layer on 1x1 cm2, Grade 2 titanium samples. The antibacterial effect was evaluated by culturing Staphylococcus aureus (ATCC 29213) on the surfaces of the samples for 8 hours, and comparing the results to that of glass as control and of pure titanium samples. Alamar Blue assay was carried out to check cytotoxicity. Results: It was proved that silver nanoparticles were present on the treated surfaces. The average diameter of the particles was 58 nm, with a 25 nm deviation and Gaussian distribution, the the filling factor was 25%. Antibacterial evaluation revealed that the nanoparticle covered samples had an antibacterial effect of 64.6% that was statistically significant. Tests also proved that the nanoparticles are safely anchored to the titanium surface and are not cytotoxic. Conclusion: Creating a silver nanoparticle layer can be an option to add antibacterial features to the implant surface and to help in the prevention of peri-implant inflammatory processes. Recent studies demonstrated that silver nanoparticles can induce pathology in mammal cells, thus safe fixation of the particles is essential to prevent them from getting into the circulation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
implants
peri-implant inflammation
oxyde layer
cytocompatibility
antibacterial effect
physical vapor deposition
geometrical model
Megjelenés:International Journal of Nanomedicine. - 2019 : 14 (2019), p. 4709-4721. -
További szerzők:Beke Dezső László (1945-) (fizikus) Biri Sándor Csarnovics István (1986-) (fizikus) Csik Attila (1975-) (fizikus) Dombrádi Zsuzsanna Rita (1983-) (molekuláris biológus, mikrobiológus) Hajdu Péter (1988-) (gyorsító üzemeltető mérnök) Hegedűs Viktória (1986-) (fogorvos) Rácz Richárd (1985-) (fizikus) Varga István (1974-) (fogszakorvos) Hegedűs Csaba (1953-) (fogszakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00041
GINOP
GINOP-2.3.2-15-2016-00022
GINOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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