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001-es BibID:BIBFORM113127
035-os BibID:(cikkazonosító)106491 (WoS)001028571700001 (Scopus)85163053491
Első szerző:Pamlényi Krisztián
Cím:Formulation and characterization of pramipexole containing buccal films for using in Parkinson's disease / Krisztián Pamlényi, Géza Regdon Jr., Orsolya Jójárt-Laczkovich, Dániel Nemes, Ildikó Bácskay, Katalin Kristó
Dátum:2023
ISSN:0928-0987
Megjegyzések:Parkinson's disease (PD) is neurodegenerative chronic illness which affects primarily the elderly over 45 years of age. The symptoms can be various, both non-motor and motor symptoms can appear. The biggest problem in the treatment of the disease is the difficulty in swallowing for the patients. However, buccal patches can solve this problem because the patients do not have to swallow the dosage form, and during application, the API can absorb from the area of the buccal mucosa quickly without causing a foreign body sensation. In our present study, we focused on the development of buccal polymer films with pramipexole dihydrochloride (PR). Films with different compositions were formulated and their mechanical properties and chemical interactions were investigated. The biocompatibility of the film compositions was examined on the TR146 buccal cell line. The permeation of PR was also monitored across the TR146 human cell line. It can be stated that the plasticizer can enhance the thickness and the breaking hardness of the films, while not decreasing their mucoadhesivity significantly. All formulations proved to have cell viability higher than 87%. Finally, we found the best composition (3% SA+1% GLY-PR-Sample1) which can be applied on the buccal mucosa in the treatment of PD.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:European Journal Of Pharmaceutical Sciences. - 187 (2023), p. 1-12. -
További szerzők:Regdon Géza Jr. Jójárt-Laczkovich Orsolya Nemes Dániel (1993-) (gyógyszerész) Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Kristó Katalin
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM103093
035-os BibID:(cikkazonosító)1633 (scopus)85137398840 (wos)000845728100001
Első szerző:Pamlényi Krisztián
Cím:Stability, Permeability and Cytotoxicity of Buccal Films in Allergy Treatment / Krisztián Pamlényi, Géza Regdon, Dániel Nemes, Ferenc Fenyvesi, Ildikó Bácskay, Katalin Kristó
Dátum:2022
ISSN:1999-4923
Megjegyzések:: Oral mucoadhesive systems, such as polymer films, are among innovative pharmaceutical products. These systems can be applied in swallowing problems and can also be used in geriatrics and paediatrics. In our earlier work, we successfully formulated buccal mucoadhesive polymer films, which contained cetirizine-hydrochloride (CTZ) as the API. The present study focused on investigating the stability and permeability of the prepared films. The stability of the films was studied with an accelerated stability test. During the stability test, thickness, breaking hardness and in vitro mucoadhesivity were analysed. Furthermore, the interactions were studied with FT-IR spectroscopy, and the changes in the amount of the API were also monitored. Cytotoxicity and cell line permeability studies were carried out on TR 146 buccal cells. Compositions that can preserve more than 85% of the API after 6 months were found. Most of the compositions had a high cell viability of more than 50%. Citric acid (CA) decreased the stability and reduced every physical parameter of the films. However, cell line studies showed that the permeability of the films was enhanced. In our work, we successfully formulated CTZ-containing buccal films with adequate stability, high cell viability and appropriate absorption properties.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
mucoadhesive
buccal films
drug delivery
alginate
cetirizine
antihistamine
stability
permeability
cytotoxicity
Megjelenés:Pharmaceutics. - 14 : 8 (2022), p. 1-15. -
További szerzők:Regdon Géza Nemes Dániel (1993-) (gyógyszerész) Fenyvesi Ferenc (1977-) (gyógyszerész, gyógyszertechnológus) Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Kristó Katalin
Pályázati támogatás:GINOP-2.3.4-15-2020-00008
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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