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001-es BibID:BIBFORM118762
035-os BibID:(cikkazonosító)1345877 (WoS)001175930800001 (Scopus)85186558578
Első szerző:Domán Marianna (biológus)
Cím:Genomic epidemiology of antifungal resistance in human and avian isolates of Candida albicans : a pilot study from the One Health perspective / Marianna Domán, Eszter Kaszab, Levente Laczkó, Krisztina Bali, László Makrai, Renátó Kovács, László Majoros, Krisztián Bányai
Dátum:2024
ISSN:2297-1769
Megjegyzések:Stress-induced genomic changes in Candida albicans contribute to the adaptation of this species to various environmental conditions. Variations of the genome composition of animal-origin C. albicans strains are largely unexplored and drug resistance or other selective pressures driving the evolution of these yeasts remained an intriguing question. Comparative genome analysis was carried out to uncover chromosomal aneuploidies and regions with loss of heterozygosity (LOH), two mechanisms that manage genome plasticity. We detected aneuploidy only in human isolates. Bird-derived isolates showed LOH in genes commonly associated with antifungal drug resistance similar to human isolates. Our study suggests that environmental fungicide usage might exert selective pressure on C. albicans infecting animals, thus contributing to the spread of potentially resistant strains between different hosts
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
yeast
aneuploidy
loss of heterozygosity
drug resistance
whole genome sequencing
Megjelenés:Frontiers in Veterinary Science. - 11 (2024), p. 1-7. -
További szerzők:Kaszab Eszter (1989-) (biológus) Laczkó Levente (1992-) (biológus) Bali Krisztina Makrai László Kovács Renátó László (1987-) (molekuláris biológus) Majoros László (1966-) (szakorvos, klinikai mikrobiológus) Bányai Krisztián
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2.

001-es BibID:BIBFORM118513
035-os BibID:(WoS)000898136200001 (cikkazonosító)1093884 (Scopus)85143892810
Első szerző:Jakab Szilvia
Cím:Corrigendum: Genetic diversity of imported PRRSV-2 strains, 2005-2020, Hungary / Szilvia Jakab, Eszter Kaszab, Szilvia Marton, Krisztián Bányai, Ádám Bálint, Imre Nemes, István Szabó
Dátum:2022
ISSN:2297-1769
Megjegyzések:Porcine reproductive and respiratory syndrome virus 2 (PRRSV-2) remains sporadic in Europe. In this study, we investigated the molecular epidemiology of PRRSV-2 infections encompassing 15 years in Hungary. Partial (423 bp long) ORF5 sequences (n = 44) from 20 Hungarian pig herds were analyzed. The study strains fell into two genetic lineages, L1 and L5, being L5 strains more prevalent (88.6 vs. 11.4%). Pairwise sequence identities within Hungarian representative PRRSV-2 strains ranged between 84.7 to 100% (nucleotide, nt) and 85 to 100% (amino acid, aa). When compared with reference strains, identity values fell between 87 and 100% (L1, nt 87?91%, aa 87?93%, reference strain IAF-exp91; L5, nt 87?100%, aa 88?100%, reference strain Ingelvac MLV). Epidemiologic examination implied that the majority of L5 strains were imported repeatedly from other European countries where Ingelvac MLV was approved for routine use. The emergence of L1 strains was thought to be associated with a single introduction and subsequent dissemination between pig farms of a large integrator. Results presented here contribute to a better understanding of the epizootiology of PRRSV-2 infections and shed light on the genetic diversity of viral strains in non-endemic countries.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Veterinary Science. - 9 (2022), p. 1093884. -
További szerzők:Kaszab Eszter (1989-) (biológus) Marton Szilvia Bányai Krisztián Bálint Ádám Nemes Imre Szabó István
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3.

001-es BibID:BIBFORM118507
035-os BibID:(WoS)000876193300001 (Scopus)85140402684 (cikkazonosító)1093884
Első szerző:Jakab Szilvia
Cím:Genetic diversity of imported PRRSV-2 strains, 2005-2020, Hungary / Szilvia Jakab, Eszter Kaszab, Szilvia Marton, Krisztián Bányai, Ádám Bálint, Imre Nemes, István Szabó
Dátum:2022
ISSN:2297-1769
Megjegyzések:Porcine reproductive and respiratory syndrome virus 2 (PRRSV-2) remains sporadic in Europe. In this study, we investigated the molecular epidemiology of PRRSV-2 infections encompassing 15 years in Hungary. Partial (423 bp long) ORF5 sequences (n = 44) from 20 Hungarian pig herds were analyzed. The study strains fell into two genetic lineages, L1 and L5, being L5 strains more prevalent (88.6 vs. 11.4%). Pairwise sequence identities within Hungarian representative PRRSV-2 strains ranged between 84.7 to 100% (nucleotide, nt) and 85 to 100% (amino acid, aa). When compared with reference strains, identity values fell between 87 and 100% (L1, nt 87-91%, aa 87-93%, reference strain IAF-exp91; L5, nt 87-100%, aa 88-100%, reference strain Ingelvac MLV). Epidemiologic examination implied that the majority of L5 strains were imported repeatedly from other European countries where Ingelvac MLV was approved for routine use. The emergence of L1 strains was thought to be associated with a single introduction and subsequent dissemination between pig farms of a large integrator. Results presented here contribute to a better understanding of the epizootiology of PRRSV-2 infections and shed light on the genetic diversity of viral strains in non-endemic countries.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Veterinary Science. - 9 (2022), p. 1-10. -
További szerzők:Kaszab Eszter (1989-) (biológus) Marton Szilvia Bányai Krisztián Bálint Ádám Nemes Imre Szabó István
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4.

001-es BibID:BIBFORM118255
035-os BibID:(cikkazonosító)1327725 (Scopus)85182813583
Első szerző:Jakab Szilvia
Cím:Genome stability assessment of PRRS vaccine strain with new ARTIC-style sequencing protocol / Szilvia Jakab, Ádám Bálint, Karolina Cseri, Krisztina Bali, Eszter Kaszab, Marianna Domán, Máté Halas, Krisztina Szarka, Krisztián Bányai
Dátum:2024
ISSN:2297-1769
Megjegyzések:A tiling amplicon sequencing protocol was developed to analyse the genome sequence stability of the modified live PRRSV vaccine strain, Porcilis MLV. The backbone of the ARTIC-style protocol was formed by 34 individual primer pairs, which were divided into two primer pools. Primer pairs were designed to amplify 532 to 588 bp fragments of the corresponding genomic region. The amplicons are suitable for sequencing on Illumina DNA sequencers with available 600-cycle sequencing kits. The concentration of primer pairs in the pools was optimized to obtain a balanced sequencing depth along the genome. Deep sequencing data of three vaccine batches were also analysed. All three vaccine batches were very similar to each other, although they also showed single nucleotide variations (SNVs) affecting less than 1 % of the genome. In the three vaccine strains, 113 to 122 SNV sites were identified; at these sites, the minority variants represented a frequency range of 1 to 48.7 percent. Additionally, the strains within the batches contained well-known length polymorphisms; the genomes of these minority deletion mutants were 135 to 222 bp shorter than the variant with the complete genome. Our results show the usefulness of ARTIC-style protocols in the evaluation of the genomic stability of PRRS MLV strains.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
deep sequencing
genetic variability
Porcilis MLV
porcine reproductive and respiratory syndrome virus
single nucleotide variation
tiling amplicon sequencing
Megjelenés:Frontiers in Veterinary Science. - 10 (2024), p. 1-8. -
További szerzők:Bálint Ádám Cseri Karolina (1985-) (molekuláris biológus) Bali Krisztina Kaszab Eszter (1989-) (biológus) Domán Marianna (1987-) (biológus) Halas Máté Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus) Bányai Krisztián
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5.

001-es BibID:BIBFORM118510
035-os BibID:(WoS)000933472600001 (Scopus)85148345984 (cikkazonosító)1058133
Első szerző:Varga-Kugler Renáta
Cím:Genetic diversity among reptilian orthoreoviruses isolated from pet snakes and lizards / Renáta Varga-Kugler, Katalin Ihász, Szilvia Marton, Eszter Kaszab, Rachel E. Marschang, Szilvia Farkas, Krisztián Bányai
Dátum:2023
ISSN:2297-1769
Megjegyzések:Reovirus infections in reptiles are frequently detected and associated with various clinical diseases; yet, our knowledge about their genetic diversity and evolutionary relationships remains limited. In this study, we characterize at the genomic level five reptile origin orthoreovirus strains isolated from exotic snakes and lizards in Hungary and Germany. The genomic organization of the study strains was similar to that of the representative strains of reptile origin reoviruses belonging to species Reptilian orthoreovirus and Testudine orthoreovirus. Additionally, all five study strains clustered with the bush viper origin reference Reptilian orthoreovirus strain, 47/02. The nucleotide sequence divergence among strains fell from 56.64 to 99.36%. Based on genome segment constellations two well separated groups were observed, which may represent two genetic lineages of reptilian orthoreoviruses we tentatively referred here as genogroups, classifying two squamata origin strains with available whole genome sequences into genogroup I (GGI) and four strains into genogroup II (GGII). The representative GGI and GGII Reptilian orthoreovirus strains are characterized by moderate-to-high nucleotide and amino acid similarities within genogroups (range, 69.45 to 99.36% and 74.64 to 100.00%), whereas lower nucleotide and amino acid similarities (range, 56.64 to 77.24% and 54.53 to 93.85%) and different structures of the bicistronic S1 segment were found between genogroups. Further studies are needed to explore the genomic diversity among reptilian reoviruses of squamata origin; this would be critical to establish a robust classification system for these viruses and to see if interaction among members of distinct lineages may result in viable progenies with novel genetic features.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Veterinary Science. - 10 (2023), p. 1-8. -
További szerzők:Ihász Katalin Marton Szilvia Kaszab Eszter (1989-) (biológus) Marschang, Rachel E. Farkas Szilvia Bányai Krisztián
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