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001-es BibID:	BIBFORM118497
035-os BibID:	(WoS)000690213000001 (Scopus)85112026538 (cikkazonosító)849
Első szerző:	Bálint Ádám
Cím:	Genetic Variability of PRRSV Vaccine Strains Used in the National Eradication Programme, Hungary / Ádám Bálint,Tamás Molnár, Sándor Kecskeméti, Gábor Kulcsár, Tibor Soós, Péter M. Szabó, Eszter Kaszab, Kinga Fornyos, Zoltán Zádori, Krisztián Bányai, István Szabó
Dátum:	2021
ISSN:	2076-393X
Megjegyzések:	Porcine reproductive and respiratory syndrome (PRRS) is a globally spread, highly infectious viral disease. Live, attenuated vaccines against PRRS virus (PRRSV) decrease virus excretion and evoke protective immunity reducing the economic damage caused by the disease. In a longitudinal molecular epidemiological study accompanying ongoing national eradication programme we evaluated the suitability of PRRSV ORF5 and ORF7 sequences to identify possible field strains of vaccine-origin. In total, 2342 ORF5 sequences and 478 ORF7 sequences were analysed. Vaccine strains were identified by sequence identity values and phylogenetic network analysis. Strains that shared greater than 98% nucleotide identity within ORF5 and/or ORF7 were considered to have originated from vaccine. A total of 882 (37.6%) ORF5 and 88 (18.4%) ORF7 sequences met these criteria. In detail, 618, 179 and 35 ORF5 and 51, 29 and 8 ORF7 sequences were related to Porcilis PRRS vaccine, Unistrain PRRS vaccine, and ReproCyc PRRS EU vaccine, respectively. Data showed that the Porcilis vaccine was genetically more stable. Whereas, the variability of the Unistrain and the ReproCyc strains was significantly higher. Given that ORF7 shares, in some instances, complete identity between a particular vaccine strain and some historic variants of field PRRSV strains, care must be taken when evaluating vaccine relatedness of a field isolate based on the ORF7. On the contrary, ORF5 sequences were more suitable to predict the vaccine origin making a distinction more robustly between field and vaccine strains. We conclude that ORF5 based molecular epidemiological studies support more efficiently the ongoing PRRS eradication programmes. The conclusions presented in this large-scale PRRS molecular epidemiological study provides a framework for future eradication programmes planned in other countries.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Vaccines. - 9 : 8 (2021), p. 1-12. -
További szerzők:	Molnár Tamás Kecskeméti Sándor Kulcsár Gábor Soós Zoltán Szabó Péter Kaszab Eszter (1989-) (biológus) Fornyos Kinga Zádori Zoltán Bányai Krisztián Szabó István
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM117940
035-os BibID:	(cikkazonosító)175 (WoS)001139768900001 (Scopus)85181965425
Első szerző:	Bálint Ádám
Cím:	Spatiotemporal Distribution of PRRSV-1 Clades in Hungary with a Focus on the Era of Disease Eradication / Ádám Bálint, Szilvia Jakab, Eszter Kaszab, Szilvia Marton, Krisztián Bányai, Sándor Kecskeméti, István Szabó
Dátum:	2024
ISSN:	2076-2615
Megjegyzések:	Porcine reproductive and respiratory syndrome (PRRS) is the cause of the most severe economic losses in the pig industry worldwide. PRRSV is extremely diverse in Europe, which poses a significant challenge to disease control within a country or any region. With the combination of phylogenetic reconstruction and network analysis, we aimed to uncover the major routes of the dispersal of PRRSV clades within Hungary. In brief, by analyzing >2600 ORF5 sequences, we identified at least 12 clades (including 6 clades within lineage 1 and 3 clades within lineage 3) common in parts of Western Europe (including Denmark, Germany and the Netherlands) and identified 2 novel clades (designated X1 and X2). Of interest, some genetic clades unique to other central European countries, such as the Czech Republic and Poland, were not identified. The pattern of PRRSV clade distribution is consistent with the route of the pig trade among countries, showing that most of the identified clades were introduced from Western Europe when fatteners were transported to Hungary. As a result of rigorous implementation of the national eradication program, the swine population was declared officially free from PRRSV. This map of viral diversity and clade distribution will serve as valuable baseline information for the maintenance of PRRSV-free status in the post-eradication era.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk disease eradication genetic diversity molecular epidemiology phylogeny porcine reproductive and respiratory syndrome PRRS
Megjelenés:	Animals. - 14 : 1 (2024), p. 1-8. -
További szerzők:	Jakab Szilvia Kaszab Eszter (1989-) (biológus) Marton Szilvia Bányai Krisztián Kecskeméti Sándor Szabó István
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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