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001-es BibID:	BIBFORM118511
035-os BibID:	(WoS)001028622300001 (Scopus)85165039685 (cikkazonosító)2137
Első szerző:	Gál Bence
Cím:	Marked Genotype Diversity among Reoviruses Isolated from Chicken in Selected East-Central European Countries / Bence Gál, Renáta Varga-Kugler, Katalin Ihász, Eszter Kaszab, Marianna Domán, Szilvia Farkas, Krisztián Bányai
Dátum:	2023
ISSN:	2076-2615
Megjegyzések:	The concern that the vaccines currently used against Avian orthoreovirus (ARV) infections are less efficient in the field justifies the need for the close monitoring of circulating ARV strains. In this study, we collected necropsy samples from various chicken breeds and tested for ARV by virus isolation, RT-PCR assay and sequence analysis. ARVs were isolated from birds showing runting-stunting syndrome, uneven growth, lameness or increased mortality, with relative detection rates of 38%, 35%, 6% and 25%, respectively. Partial ?C gene sequences were determined for nearly 90% of ARV isolates. The isolates could be classified into one of the major genetic clusters. Interestingly, cluster 2 and cluster 5 were isolated from vaccinated broiler breeders, while clusters 1 to 4 were isolated from unvaccinated broilers. The isolates shared less than 75% amino acid identities with the vaccine strains (range, 44.3?74.6%). This study reaffirms the global distribution of the major genetic clusters of ARVs in chicken. The diversity of ARV strains isolated from unvaccinated broilers was greater than those detected from vaccinated animals, however, the relative importance of passive and active immunity on the selection of novel strains in different chicken breeds needs to be better understood.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Animals. - 13 : 13 (2023), p. 1-13. -
További szerzők:	Varga-Kugler Renáta Ihász Katalin Kaszab Eszter (1989-) (biológus) Domán Marianna (1987-) (biológus) Farkas Szilvia Bányai Krisztián
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM117251
035-os BibID:	(Scopus)85178361033 (cikkazonosító)3504 (WoS)001122834800001
Első szerző:	Gál Bence
Cím:	A Snapshot on the Genomic Epidemiology of Turkey Reovirus Infections, Hungary / Bence Gál, Renáta Varga-Kugler, Katalin Ihász, Eszter Kaszab, Szilvia Farkas, Szilvia Marton, Vito Martella, Krisztián Bányai
Dátum:	2023
ISSN:	2076-2615
Megjegyzések:	Reovirus infections in turkeys are associated with arthritis and lameness. Viral genome sequence data are scarce, which makes an accurate description of the viral evolution and epidemiology difficult. In this study, we isolated and characterized turkey reoviruses from Hungary. The isolates were identified in 2016; these isolates were compared with earlier Hungarian turkey reovirus strains and turkey reoviruses isolated in the 2010s in the United States. Gene-wise sequence and phylogenetic analyses identified the cell-receptor binding protein and the main neutralization antigen, ?C, to be the most conserved. The most genetically diverse gene was another surface antigen coding gene, ?B. This gene was shown to undergo frequent reassortment among chicken and turkey origin reoviruses. Additional reassortment events were found primarily within members of the homologous turkey reovirus clade. Our data showed evidence for low variability among strains isolated from independent outbreaks, a finding that suggests a common source of turkey reoviruses in Hungarian turkey flocks. Given that commercial vaccines are not available, identification of the source of these founder virus strains would permit a more efficient prevention of disease outbreaks before young birds are settled to fattening facilities.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Avian orthoreovirus interspecies transmission phylogenetic analysis reassortment Spinareoviridae whole-genome sequencing
Megjelenés:	Animals. - 13 : 22 (2023), p. 1-12. -
További szerzők:	Varga-Kugler Renáta Ihász Katalin Kaszab Eszter (1989-) (biológus) Farkas Szilvia Marton Szilvia Martella, Vito Bányai Krisztián
Pályázati támogatás:	RRF-2.3.1-21-2022-00001 Egyéb TKP2021-EGA-01 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM118510
035-os BibID:	(WoS)000933472600001 (Scopus)85148345984 (cikkazonosító)1058133
Első szerző:	Varga-Kugler Renáta
Cím:	Genetic diversity among reptilian orthoreoviruses isolated from pet snakes and lizards / Renáta Varga-Kugler, Katalin Ihász, Szilvia Marton, Eszter Kaszab, Rachel E. Marschang, Szilvia Farkas, Krisztián Bányai
Dátum:	2023
ISSN:	2297-1769
Megjegyzések:	Reovirus infections in reptiles are frequently detected and associated with various clinical diseases; yet, our knowledge about their genetic diversity and evolutionary relationships remains limited. In this study, we characterize at the genomic level five reptile origin orthoreovirus strains isolated from exotic snakes and lizards in Hungary and Germany. The genomic organization of the study strains was similar to that of the representative strains of reptile origin reoviruses belonging to species Reptilian orthoreovirus and Testudine orthoreovirus. Additionally, all five study strains clustered with the bush viper origin reference Reptilian orthoreovirus strain, 47/02. The nucleotide sequence divergence among strains fell from 56.64 to 99.36%. Based on genome segment constellations two well separated groups were observed, which may represent two genetic lineages of reptilian orthoreoviruses we tentatively referred here as genogroups, classifying two squamata origin strains with available whole genome sequences into genogroup I (GGI) and four strains into genogroup II (GGII). The representative GGI and GGII Reptilian orthoreovirus strains are characterized by moderate-to-high nucleotide and amino acid similarities within genogroups (range, 69.45 to 99.36% and 74.64 to 100.00%), whereas lower nucleotide and amino acid similarities (range, 56.64 to 77.24% and 54.53 to 93.85%) and different structures of the bicistronic S1 segment were found between genogroups. Further studies are needed to explore the genomic diversity among reptilian reoviruses of squamata origin; this would be critical to establish a robust classification system for these viruses and to see if interaction among members of distinct lineages may result in viable progenies with novel genetic features.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Veterinary Science. - 10 (2023), p. 1-8. -
További szerzők:	Ihász Katalin Marton Szilvia Kaszab Eszter (1989-) (biológus) Marschang, Rachel E. Farkas Szilvia Bányai Krisztián
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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