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1.

001-es BibID:BIBFORM117940
035-os BibID:(cikkazonosító)175 (WoS)001139768900001 (Scopus)85181965425
Első szerző:Bálint Ádám
Cím:Spatiotemporal Distribution of PRRSV-1 Clades in Hungary with a Focus on the Era of Disease Eradication / Ádám Bálint, Szilvia Jakab, Eszter Kaszab, Szilvia Marton, Krisztián Bányai, Sándor Kecskeméti, István Szabó
Dátum:2024
ISSN:2076-2615
Megjegyzések:Porcine reproductive and respiratory syndrome (PRRS) is the cause of the most severe economic losses in the pig industry worldwide. PRRSV is extremely diverse in Europe, which poses a significant challenge to disease control within a country or any region. With the combination of phylogenetic reconstruction and network analysis, we aimed to uncover the major routes of the dispersal of PRRSV clades within Hungary. In brief, by analyzing >2600 ORF5 sequences, we identified at least 12 clades (including 6 clades within lineage 1 and 3 clades within lineage 3) common in parts of Western Europe (including Denmark, Germany and the Netherlands) and identified 2 novel clades (designated X1 and X2). Of interest, some genetic clades unique to other central European countries, such as the Czech Republic and Poland, were not identified. The pattern of PRRSV clade distribution is consistent with the route of the pig trade among countries, showing that most of the identified clades were introduced from Western Europe when fatteners were transported to Hungary. As a result of rigorous implementation of the national eradication program, the swine population was declared officially free from PRRSV. This map of viral diversity and clade distribution will serve as valuable baseline information for the maintenance of PRRSV-free status in the post-eradication era.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
disease eradication
genetic diversity
molecular epidemiology
phylogeny
porcine reproductive and respiratory syndrome
PRRS
Megjelenés:Animals. - 14 : 1 (2024), p. 1-8. -
További szerzők:Jakab Szilvia Kaszab Eszter (1989-) (biológus) Marton Szilvia Bányai Krisztián Kecskeméti Sándor Szabó István
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2.

001-es BibID:BIBFORM118503
035-os BibID:(WoS)000770971900001 (Scopus)85126803924
Első szerző:Fehér Enikő (molekuláris biológus, mikrobiológus)
Cím:A novel gyrovirus in a common pheasant (Phasianus colchicus) with poult enteritis and mortality syndrome /Enikő Fehér, Krisztina Bali, Eszter Kaszab, Katalin Ihász, Szilvia Jakab, Borbála Nagy, Krisztina Ursu, Szilvia L. Farkas, Krisztián Bányai
Dátum:2022
ISSN:0304-8608
Megjegyzések:A novel gyrovirus was detected in an intestinal specimen of a common pheasant that died due to poult enteritis and mortality syndrome. The genome of the pheasant-associated gyrovirus (PAGyV) is 2353 nucleotides (nt) long and contains putative genes for the VP1, VP2, and VP3 proteins in an arrangement that is typical for gyroviruses. Gyrovirus-specific motifs were identified in both the coding region and the intergenic region of the PAGyV genome. The VP1 of PAGyV shares up to 67.6% pairwise nt sequence identity with reference sequences and forms a distinct branch in the phylogenetic tree. Thus, according to the recently described species demarcation criteria, PAGyV belongs to a novel species in the genus Gyrovirus, family Anelloviridae, for which we propose the name "Gyrovirus phaco 1".
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Archives Of Virology. - 167 : 5 (2022), p. 1349-1353. -
További szerzők:Bali Krisztina Kaszab Eszter (1989-) (biológus) Ihász Katalin Jakab Szilvia Nagy Borbála Ursu Krisztina Farkas Szilvia L. Bányai Krisztián
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3.

001-es BibID:BIBFORM118498
035-os BibID:(Cikkazonosító)1592 (WoS)000690239600001 (Scopus)85113142544
Első szerző:Fehér Enikő (molekuláris biológus, mikrobiológus)
Cím:Genomic Epidemiology and Evolution of Duck Hepatitis A Virus / Enikő Fehér, Szilvia Jakab, Krisztina Bali, Eszter Kaszab, Borbála Nagy, Katalin Ihász, Ádám Bálint, Vilmos Palya, Krisztián Bányai
Dátum:2021
ISSN:1999-4915
Megjegyzések:Duck hepatitis A virus (DHAV), an avian picornavirus, causes high-mortality acute disease in ducklings. Among the three serotypes, DHAV-1 is globally distributed, whereas DHAV-2 and DHAV-3 serotypes are chiefly restricted to Southeast Asia. In this study, we analyzed the genomic evolution of DHAV-1 strains using extant GenBank records and genomic sequences of 10 DHAV-1 strains originating from a large disease outbreak in 2004?2005, in Hungary. Recombination analysis revealed intragenotype recombination within DHAV-1 as well as intergenotype recombination events involving DHAV-1 and DHAV-3 strains. The intergenotype recombination occurred in the VP0 region. Diversifying selection seems to act at sites of certain genomic regions. Calculations estimated slightly lower rates of evolution of DHAV-1 (mean rates for individual protein coding regions, 5.6286 ? 10?4 to 1.1147 ? 10?3 substitutions per site per year) compared to other picornaviruses. The observed evolutionary mechanisms indicate that whole-genome-based analysis of DHAV strains is needed to better understand the emergence of novel strains and their geographical dispersal.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Viruses-Basel. - 13 : 8 (2021), p. 1-10. -
További szerzők:Jakab Szilvia Bali Krisztina Kaszab Eszter (1989-) (biológus) Nagy Borbála Ihász Katalin Bálint Ádám Palya Vilmos Bányai Krisztián
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4.

001-es BibID:BIBFORM118493
035-os BibID:(WoS)000620427500002 (Scopus)85101201472
Első szerző:Homonnay Zalán G.
Cím:Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events / Zalán Homonnay, Szilvia Jakab, Krisztina Bali, Eszter Kaszab, Tamás Mató, István Kiss, Vilmos Palya, Krisztián Bányai
Dátum:2021
ISSN:0304-8608
Megjegyzések:We determined the genomic sequence of a Ukrainian strain of fowl adenovirus B (FAdV-B). The isolate (D2453/1) shared 97.2% to 98.4% nucleotide sequence identity with other viruses belonging to the species Fowl aviadenovirus B. Marked genetic divergence was seen in the hexon, fiber, and ORF19 genes, and phylogenetic analysis suggested that recombination events had occurred in these regions. Our analysis revealed mosaicism in the recombination patterns, a finding that has also been described in the genomes of strains of FAdV-D and FAdV-E. The shared recombination breakpoints, affecting the same genomic regions in viruses belonging to different species, suggest that similar selection mechanisms are acting on the key neutralization antigens and epitopes in viruses of different FAdV species.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Archives Of Virology. - 166 : 5 (2021), p. 1477-1480. -
További szerzők:Jakab Szilvia Bali Krisztina Kaszab Eszter (1989-) (biológus) Mató Tamás Kiss István Palya Vilmos Bányai Krisztián
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM118513
035-os BibID:(WoS)000898136200001 (cikkazonosító)1093884 (Scopus)85143892810
Első szerző:Jakab Szilvia
Cím:Corrigendum: Genetic diversity of imported PRRSV-2 strains, 2005-2020, Hungary / Szilvia Jakab, Eszter Kaszab, Szilvia Marton, Krisztián Bányai, Ádám Bálint, Imre Nemes, István Szabó
Dátum:2022
ISSN:2297-1769
Megjegyzések:Porcine reproductive and respiratory syndrome virus 2 (PRRSV-2) remains sporadic in Europe. In this study, we investigated the molecular epidemiology of PRRSV-2 infections encompassing 15 years in Hungary. Partial (423 bp long) ORF5 sequences (n = 44) from 20 Hungarian pig herds were analyzed. The study strains fell into two genetic lineages, L1 and L5, being L5 strains more prevalent (88.6 vs. 11.4%). Pairwise sequence identities within Hungarian representative PRRSV-2 strains ranged between 84.7 to 100% (nucleotide, nt) and 85 to 100% (amino acid, aa). When compared with reference strains, identity values fell between 87 and 100% (L1, nt 87?91%, aa 87?93%, reference strain IAF-exp91; L5, nt 87?100%, aa 88?100%, reference strain Ingelvac MLV). Epidemiologic examination implied that the majority of L5 strains were imported repeatedly from other European countries where Ingelvac MLV was approved for routine use. The emergence of L1 strains was thought to be associated with a single introduction and subsequent dissemination between pig farms of a large integrator. Results presented here contribute to a better understanding of the epizootiology of PRRSV-2 infections and shed light on the genetic diversity of viral strains in non-endemic countries.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Veterinary Science. - 9 (2022), p. 1093884. -
További szerzők:Kaszab Eszter (1989-) (biológus) Marton Szilvia Bányai Krisztián Bálint Ádám Nemes Imre Szabó István
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Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM118512
035-os BibID:(WoS)001075847600001 (Scopus)85172808154 (cikkazonosító)2819
Első szerző:Jakab Szilvia
Cím:Genomic Epidemiology and Evolution of Fowl Adenovirus 1 / Szilvia Jakab, Krisztina Bali, Zalán Homonnay, Eszter Kaszab, Katalin Ihász, Enikő Fehér, Tamás Mató, István Kiss, Vilmos Palya, Krisztián Bányai
Dátum:2023
ISSN:2076-2615
Megjegyzések:Fowl adenovirus 1 (FAdV-1) is the main cause of gizzard erosion in chickens. Whole genome sequencing and sequence analyses of 32 FAdV-1 strains from a global collection provided evidence that multiple recombination events have occurred along the entire genome. In gene-wise phylogenies, only the adenoviral pol gene formed a tree topology that corresponded to whole genome-based phylogeny. Virus genetic features that were clearly connected to gizzard erosion were not identified in our analyses. However, some genome variants tended to be more frequently identified from birds with gizzard erosion and strains isolated from healthy birds or birds with non-specific pathologies tended to form common clusters in multiple gene phylogenies. Our data show that the genetic diversity is greater, and the evolutionary mechanisms are more complex within FAdV-1 than previously thought. The implications of these findings for viral pathogenesis and epidemiology await further investigation.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Animals. - 13 : 18 (2023), p. 1-9. -
További szerzők:Bali Krisztina Homonnay Zalán G. Kaszab Eszter (1989-) (biológus) Ihász Katalin Fehér Enikő (1981-) (molekuláris biológus, mikrobiológus) Mató Tamás Kiss István Palya Vilmos Bányai Krisztián
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Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM118507
035-os BibID:(WoS)000876193300001 (Scopus)85140402684 (cikkazonosító)1093884
Első szerző:Jakab Szilvia
Cím:Genetic diversity of imported PRRSV-2 strains, 2005-2020, Hungary / Szilvia Jakab, Eszter Kaszab, Szilvia Marton, Krisztián Bányai, Ádám Bálint, Imre Nemes, István Szabó
Dátum:2022
ISSN:2297-1769
Megjegyzések:Porcine reproductive and respiratory syndrome virus 2 (PRRSV-2) remains sporadic in Europe. In this study, we investigated the molecular epidemiology of PRRSV-2 infections encompassing 15 years in Hungary. Partial (423 bp long) ORF5 sequences (n = 44) from 20 Hungarian pig herds were analyzed. The study strains fell into two genetic lineages, L1 and L5, being L5 strains more prevalent (88.6 vs. 11.4%). Pairwise sequence identities within Hungarian representative PRRSV-2 strains ranged between 84.7 to 100% (nucleotide, nt) and 85 to 100% (amino acid, aa). When compared with reference strains, identity values fell between 87 and 100% (L1, nt 87-91%, aa 87-93%, reference strain IAF-exp91; L5, nt 87-100%, aa 88-100%, reference strain Ingelvac MLV). Epidemiologic examination implied that the majority of L5 strains were imported repeatedly from other European countries where Ingelvac MLV was approved for routine use. The emergence of L1 strains was thought to be associated with a single introduction and subsequent dissemination between pig farms of a large integrator. Results presented here contribute to a better understanding of the epizootiology of PRRSV-2 infections and shed light on the genetic diversity of viral strains in non-endemic countries.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Veterinary Science. - 9 (2022), p. 1-10. -
További szerzők:Kaszab Eszter (1989-) (biológus) Marton Szilvia Bányai Krisztián Bálint Ádám Nemes Imre Szabó István
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Intézményi repozitóriumban (DEA) tárolt változat
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8.

001-es BibID:BIBFORM118255
035-os BibID:(cikkazonosító)1327725 (Scopus)85182813583
Első szerző:Jakab Szilvia
Cím:Genome stability assessment of PRRS vaccine strain with new ARTIC-style sequencing protocol / Szilvia Jakab, Ádám Bálint, Karolina Cseri, Krisztina Bali, Eszter Kaszab, Marianna Domán, Máté Halas, Krisztina Szarka, Krisztián Bányai
Dátum:2024
ISSN:2297-1769
Megjegyzések:A tiling amplicon sequencing protocol was developed to analyse the genome sequence stability of the modified live PRRSV vaccine strain, Porcilis MLV. The backbone of the ARTIC-style protocol was formed by 34 individual primer pairs, which were divided into two primer pools. Primer pairs were designed to amplify 532 to 588 bp fragments of the corresponding genomic region. The amplicons are suitable for sequencing on Illumina DNA sequencers with available 600-cycle sequencing kits. The concentration of primer pairs in the pools was optimized to obtain a balanced sequencing depth along the genome. Deep sequencing data of three vaccine batches were also analysed. All three vaccine batches were very similar to each other, although they also showed single nucleotide variations (SNVs) affecting less than 1 % of the genome. In the three vaccine strains, 113 to 122 SNV sites were identified; at these sites, the minority variants represented a frequency range of 1 to 48.7 percent. Additionally, the strains within the batches contained well-known length polymorphisms; the genomes of these minority deletion mutants were 135 to 222 bp shorter than the variant with the complete genome. Our results show the usefulness of ARTIC-style protocols in the evaluation of the genomic stability of PRRS MLV strains.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
deep sequencing
genetic variability
Porcilis MLV
porcine reproductive and respiratory syndrome virus
single nucleotide variation
tiling amplicon sequencing
Megjelenés:Frontiers in Veterinary Science. - 10 (2024), p. 1-8. -
További szerzők:Bálint Ádám Cseri Karolina (1985-) (molekuláris biológus) Bali Krisztina Kaszab Eszter (1989-) (biológus) Domán Marianna (1987-) (biológus) Halas Máté Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus) Bányai Krisztián
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Intézményi repozitóriumban (DEA) tárolt változat
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