CCL

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001-es BibID:BIBFORM101421
035-os BibID:(cikkazonosító)4284 (scopus)85128130388 (wos)000785465100001
Első szerző:Buglyó Gergely (genetikus)
Cím:Liquid Biopsy as a Source of Nucleic Acid Biomarkers in the Diagnosis and Management of Lynch Syndrome / Gergely Buglyó, Jakub Styk, Ondrej Pös, Ádám Csók, Vanda Repiska, Beáta Soltész, Tomas Szemes, Bálint Nagy
Dátum:2022
ISSN:1661-6596 1422-0067
Megjegyzések:Lynch syndrome (LS) is an autosomal dominant inherited cancer predisposition disorder, which may manifest as colorectal cancer (CRC), endometrial cancer (EC) or other malignancies of the gastrointestinal and genitourinary tract as well as the skin and brain. Its genetic cause is a defect in one of the four key DNA mismatch repair (MMR) loci. Testing of patients at risk is currently based on the absence of MMR protein staining and detection of mutations in cancer tissue and the germline, microsatellite instability (MSI) and the hypermethylated state of the MLH1 promoter. If LS is shown to have caused CRC, lifetime follow-up with regular screening (most importantly, colonoscopy) is required. In recent years, DNA and RNA markers extracted from liquid biopsies have found some use in the clinical diagnosis of LS. They have the potential to greatly enhance the efficiency of the follow-up process by making it minimally invasive, reproducible, and time effective. Here, we review markers reported in the literature and their current clinical applications, and we comment on possible future directions.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Lynch syndrome
colorectal cancer
screening
liquid biopsy
circulating nucleic acids
biomarker
Megjelenés:International Journal Of Molecular Sciences. - 23 : 8 (2022), p. 4284. -
További szerzők:Styk, Jakub Pös, Ondrej (1990-) (biológus) Csók Ádám (1994-) (biológus) Repiska Vanda Soltész Beáta (1987-) (molekuláris biológus) Szemes, Tomas (1980-) (biológus) Nagy Bálint (1956-) (molekuláris genetikus)
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2.

001-es BibID:BIBFORM111719
035-os BibID:(cikkazonosító)8793 (WoS)000996948500001 (Scopus)85160377221
Első szerző:Csók Ádám (biológus)
Cím:Alterations of miRNA Expression in Diffuse Hyperplastic Perilobar Nephroblastomatosis : Mapping the Way to Understanding Wilms' Tumor Development and Differential Diagnosis / Csók Ádám, Micsik Tamás, Magyar Zsófia, Tornóczky Tamás, Kuthi Levente, Nishi Yumika, Szirák Krisztina, Csóka Monika, Ottóffy Gábor, Soltész Beáta, Balogh István, Buglyó Gergely
Dátum:2023
ISSN:1422-0067
Megjegyzések:Wilms' tumor (WT) is the most common renal malignancy in children. In diffuse hyperplastic perilobar nephroblastomatosis (DHPLN), nephrogenic rests result in a bulky enlargement of the kidney, a condition considered as a premalignant state before WT. Despite relevant clinical differences between WT and DHPLN, they are often challenging to distinguish based on histology. Molecular markers would improve differential diagnosis, but none are available at present. In our study, we investigated the potential of microRNAs (miRNAs) as such biomarkers, also aiming to shed light on the chronological order of expression changes. Formalin-fixed, paraffin-embedded (FFPE) samples from four DHPLN cases and adjacent healthy tissues were tested using a PCR array containing primers for 84 miRNAs implicated in genitourinary cancer. Expression in DHPLN was compared to WT data available in dbDEMC. Let-7, miR-135, miR-146a-5p, miR-182-5p, miR-183-5p, miR-20b-3p, miR-29b-3p, miR-195-5p and miR-17-5p showed potential to be used as biomarkers to distinguish WT and DHPLN in cases when traditional differential diagnosis is inconclusive. Our study also revealed miRNAs which may play a role in the initial steps of the pathogenesis (at a precancerous stage) and ones which become deregulated later in WT. More experiments are needed to confirm our observations and find new candidate markers.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Wilms' tumor
nephrogenic rest
diffuse hyperplastic perilobar nephroblastomatosis
miRNA
formalin-fixed, paraffin-embedded sample
Megjelenés:International Journal Of Molecular Sciences. - 24 : 10 (2023), p. 1-16. -
További szerzők:Micsik Tamás Magyar Zsófia Tornóczky Tamás Kuthi Levente Nishi, Yumika Szirák Krisztina (1973-) (molekuláris genetikus) Csóka Mónika Ottóffy Gábor Soltész Beáta (1987-) (molekuláris biológus) Balogh István (1972-) (molekuláris biológus, genetikus) Buglyó Gergely (1980-) (genetikus)
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3.

001-es BibID:BIBFORM112946
035-os BibID:(cikkazonosító)10520 (WoS)001030973400001 (Scopus)85164844125
Első szerző:Pös, Ondrej (biológus)
Cím:Cross-Kingdom Interaction of miRNAs and Gut Microbiota with Non-Invasive Diagnostic and Therapeutic Implications in Colorectal Cancer / Pös Ondrej, Styk Jakub, Buglyó Gergely, Zeman Michal, Lukyova Lydia, Bernatova Kamila, Hrckova Turnova Evelina, Rendek Tomas, Csók Ádám, Repiska Vanda, Nagy Bálint, Szemes Tomas
Dátum:2023
ISSN:1422-0067
Megjegyzések:Colorectal cancer (CRC) has one of the highest incidences among all types of malignant diseases, affecting millions of people worldwide. It shows slow progression, making it preventable. However, this is not the case due to shortcomings in its diagnostic and management procedure and a lack of effective non-invasive biomarkers for screening. Here, we discuss CRC-associated microRNAs (miRNAs) and gut microbial species with potential as CRC diagnostic and therapy biomarkers. We provide rich evidence of cross-kingdom miRNA-mediated interactions between the host and gut microbiome. miRNAs have emerged with the ability to shape the composition and dynamics of gut microbiota. Intestinal microbes can uptake miRNAs, which in turn influence microbial growth and provide the ability to regulate the abundance of various microbial species. In the context of CRC, targeting miRNAs could aid in manipulating the balance of the microbiota. Our findings suggest the need for correlation analysis between the composition of the gut microbiome and the miRNA expression profile.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
colorectal cancer
biomarker
gut microbiota
microRNA
Megjelenés:International Journal Of Molecular Sciences. - 24 : 13 (2023), p. 1-21. -
További szerzők:Styk, Jakub Buglyó Gergely (1980-) (genetikus) Zeman, Michal Lukyova, Lydia Bernatova, Kamila Hrckova Turnova, Evelina Rendek, Tomas Csók Ádám (1994-) (biológus) Repiska Vanda Nagy Bálint (1956-) (molekuláris genetikus) Szemes, Tomas (1980-) (biológus)
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