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001-es BibID:	BIBFORM117391
035-os BibID:	(Scopus)85124573206
Első szerző:	Dézsi László
Cím:	A naturally hypersensitive porcine model may help understand the mechanism of COVID-19 mRNA vaccine-induced rare (pseudo) allergic reactions : complement activation as a possible contributing factor / László Dézsi, Tamás Mészáros, Gergely Kozma, Mária H-Velkei, Csaba Zs. Oláh, Miklós Szabó, Zsófia Patkó, Tamás Fülöp, Mark Hennies, Miklós Szebeni, Bálint András Barta, Béla Merkely, Tamás Radovits, János Szebeni
Dátum:	2022
ISSN:	2509-2715 2509-2723
Megjegyzések:	A tiny fraction of people immunized with lipid nanoparticle (LNP)-enclosed mRNA (LNP-mRNA) vaccines develop allergic symptoms following their first or subsequent vaccinations, including anaphylaxis. These reactions resemble complement (C) activation-related pseudoallergy (CARPA) to i.v. administered liposomes, for which pigs provide a naturally oversensitive model. Using this model, we injected i.v. the human vaccination dose (HVD) of BNT162b2 (Comirnaty, CMT) or its 2-fold (2x) or 5-fold (5x) amounts and measured the hemodynamic changes and other parameters of CARPA. We observed in 6 of 14 pigs transient pulmonary hypertension along with thromboxane A2 release into the blood and other hemodynamic and blood cell changes, including hypertension, granulocytosis, lymphopenia, and thrombocytopenia. One pig injected with 5x CMT developed an anaphylactic shock requiring resuscitation, while a repeat dose failed to induce the reaction, implying tachyphylaxis. These typical CARPA symptoms could not be linked to animal age, sex, prior immune stimulation with zymosan, immunization of animals with Comirnaty i.v., or i.m. 2 weeks before the vaccine challenge, and anti-PEG IgM levels in Comirnaty-immunized pigs. Nevertheless, IgM binding to the whole vaccine, used as antigen in an ELISA, was significantly higher in reactive animals compared to non-reactive ones. Incubation of Comirnaty with pig serum in vitro showed significant elevations of C3a anaphylatoxin and sC5b-9, the C-terminal complex. These data raise the possibility that C activation plays a causal or contributing role in the rare HSRs to Comirnaty and other vaccines with similar side effects. Further studies are needed to uncover the factors controlling these vaccine reactions in pigs and to understand their translational value to humans
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Anaphylatoxins CARPA Complement COVID-19 Hemodynamic changes Pigs Pseudoallergy Shock
Megjelenés:	GeroScience. - 44 : 2 (2022), p. 597-618. -
További szerzők:	Mészáros Tamás Kozma Gergely H-Velkei Mária Oláh Csaba (1972-) (idegsebész) Szabó Miklós (1980-) (tüdőgyógyász) Patkó Zsófia Fülöp Tamás Hennies, Mark Szebeni Miklós Barta Bálint András Merkely Béla (1965-) (orvos) Radovits Tamás Szebeni János
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001-es BibID:	BIBFORM117390
035-os BibID:	(Scopus)85152334418 (cikkazonosító)6203
Első szerző:	Dojcsák Dalma
Cím:	The Alterations of Serum N-glycome in Response to SARS-CoV-2 Vaccination / Dalma Dojcsák, Zsófia Kardos, Miklós Szabó, Csaba Oláh, Zsolt Körömi, Béla Viskolcz, Csaba Váradi
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a global concern since its outbreak in 2019, with one of the main solutions being vaccination. Altered glycosylation has been described in patients after SARS-CoV-2 infection, while the effect of vaccination on serum glycoproteins remained unexplored. In this study, total serum glycosylation was analyzed in patients after SARS-CoV-2 infection and/or mRNA vaccination in order to identify potential glycosylation-based alterations. Enzyme-linked immunosorbent assay was applied to identify post-COVID-19 and post-Vaccinated patients and rule out potential outliers. Serum samples were deglycosylated by PNGase F digestion, and the released glycans were fluorescently derivatized using procainamide labeling. Solid-phase extraction was used to purify the labeled glycans followed by the analysis of hydrophilic-interaction liquid chromatography with fluorescence and mass-spectrometric detection. Alterations of serum N-glycome in response to SARS-CoV-2 infection and mRNA vaccination were revealed by linear discriminant analysis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk serum glycosylation COVID-19 vaccination liquid chromatography mass spectrometry
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 7 (2023), p. 1-7. -
További szerzők:	Kardos Zsófia Szabó Miklós (1980-) (tüdőgyógyász) Oláh Csaba (1972-) (idegsebész) Körömi Zsolt Viskolcz Béla Váradi Csaba
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001-es BibID:	BIBFORM108005
035-os BibID:	(cikkazonosító)349 (Scopus)85148850132 (WoS)000938286900001
Első szerző:	Kardos Zsófia
Cím:	Tocilizumab in Combination with Corticosteroids in COVID-19 Pneumonia : a Single-centre Retrospective Controlled Study / Zsófia Kardos, Miklós Szabó, Zsuzsanna Baráth, Ágnes Miksi, Csaba Oláh, Ádám Kozma, József A. Gergely, Eszter Csánky, Zoltán Szekanecz
Dátum:	2023
ISSN:	2227-9059
Megjegyzések:	Abstract: Introduction: Interleukin 6 receptor inhibition by tocilizumab (TCZ) has been effectively used worldwide for the treatment of multisystem inflammatory syndrome (MIS) associated with COVID-19. In this single centre study, we compared the outcome of COVID-19 pneumonia in TCZ treated vs. untreated (control) patients. We wished to compare TCZ administration in the general ward vs. in the intensive care unit (ICU). We also studied the role of a consulting rheumatologist in the management of severe COVID-19 pneumonia. Patients and methods: In our patients, COVID 19 pneumonia was confirmed by SARS-CoV-2 PCR, chest X-ray, and CT. We compared patients selected for TCZ treatment with TCZ-untreated age- and sex-matched controls. All patients received corticosteroids. In the TCZ-treated group, patients received one or two doses of TCZ 8 mg/kg IV in combination with corticosteroids. We recorded age, sex, symptom duration, oxygen saturation (SaO2), partial arterial oxygen pressure (PaO2), total white blood cell (WBC), absolute neutrophil, absolute lymphocyte and platelet counts, CRP, ferritin, IL-6, LDH, procalcitonin (PCT), and D-di mer. The primary outcome parameters were the need for ICU, ventilation, death, and time of hos pitalisation. Results: Altogether, 104 patients, 52 TCZ-treated and 52 TCZ-untreated, were included in this study. At baseline, the TCZ-treated patient group indeed had more pronounced COVID-19- related MIS compared to controls. Consultation with a rheumatologist was performed in 60% vs. 40% of cases. Nineteen patients (37%) received one, while 33 (63%) received two TCZ doses. TCZ was administered to 28 patients (54%) in the general ward and to 24 (46%) in the ICU. TCZ treatment was found to be safe in our COVID-19 pneumonia patients. TCZ treatment favourably influenced MIS biomarkers, and was associated with better clinical outcomes compared to controls. Patients receiving TCZ treatment in combination with corticosteroids already in the general ward exerted much better outcomes than those treated in the ICU. Consultation with a rheumatologist also im proved outcome. Conclusions: We successfully used TCZ in combination with corticosteroids in Hungarian COVID-19 pneumonia patients. We pointed out the importance of early treatment al ready in the general ward, and the involvement of a rheumatologist in making treatment decisions.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk COVID-19 IL-6 receptor tocilizumab pneumonia efficacy
Megjelenés:	Biomedicines. - 11 : 2 (2023), p. 1-15. -
További szerzők:	Szabó Miklós (1980-) (tüdőgyógyász) Baráth Zsuzsa Miksi Ágnes Oláh Csaba (1972-) (idegsebész) Kozma Ádám Gergely József A. Csánky Eszter (1959-) (tüdőgyógyász, klinikai immunológus, allergológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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