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001-es BibID:	BIBFORM016467
Első szerző:	Józsa Éva (vegyész, kémia tanár)
Cím:	Nickel(II) and mixed metal complexes of amyloid-beta N-terminus / Éva Józsa, Katalin Ősz, Csilla Kállay, Paolo de Bona, Chiara A. Damante, Giuseppe Pappalardo, Enrico Rizzarelli, Imre Sóvágó
Dátum:	2010
ISSN:	1477-9226
Megjegyzések:	Nickel(II) complexes of A beta(1-16)Y10A and its smaller fragments including A beta(1-4), A beta(1-6), Ac-A beta(1-6) and Ac-A beta(8-16)Y10A have been studied by potentiometric, UV-Vis and circular dichroism spectroscopic measurements. The formation of mixed metal complexes and the distribution of metal ions among the possible coordination sites in the Cu(II)-Ni(II)-A beta(1-16)Y10A and Cu(II)-Ni(II)-Zn(II)-A beta(1-16)Y10A systems have also been evaluated. It was found that the hexadecapeptide and its fragments are effective nickel(II) binding ligands and complex formation processes of nickel(II) ions are quite similar to those of copper(II). Formation of mono-and di-nuclear complexes was detected in the nickel(II)-A beta(1-16)Y10A system suggesting the existence of two separated metal binding motifs: the N-terminus and internal histidyl residues. The preference for the coordination at the N-terminus was supported by the spectroscopic measurements but in equilibrium with the metal binding at the internal histidyl sites. Neither zinc(II) nor nickel(II) can, however, substitute copper(II) in the mixed metal complexes of A beta(1-16)Y10A, but both metal ions are able to alter the distribution of copper(II) ions among the various binding sites. Both N-terminus (amino and His6) and internal histidyl residues (His13 and His14) can work as dinuclear binding motifs, preferably accommodating copper(II) and zinc(II), respectively, while nickel(II) can occupy the remaining free coordination sites.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban prion protein copper(ii) complexes alzheimers-disease peptide-fragments a-beta binding coordination ions residues tyrosine
Megjelenés:	Dalton Transactions. - 39 : 30 (2010), p. 7046-7053. -
További szerzők:	Ősz Katalin (1975-) (vegyész) Kállay Csilla (1978-) (vegyész) De Bona, Paolo Damante, Chiara A. Pappalardo, Giuseppe Rizzarelli, Enrico Sóvágó Imre (1946-) (vegyész)
Pályázati támogatás:	NKTH-OTKA K 68482 OTKA 77586 OTKA T 048352 OTKA T048352 OTKA 77586 OTKA
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL
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