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1.

001-es BibID:BIBFORM060508
Első szerző:Albert Réka
Cím:Triamcinolone regulated apopto-phagocytic gene expression patterns in the clearance of dying retinal pigment epithelial cells. A key role of Mertk in the enhanced phagocytosis / Réka Albert, Endre Kristóf, Gábor Zahuczky, Mária Szatmári-Tóth, Zoltán Veréb, Brigitta Oláh, Morten C. Moe, Andrea Facskó, László Fésüs, Goran Petrovski
Dátum:2015
ISSN:0304-4165
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Biochimica et Biophysica Acta (BBA). General Subjects. - 1850 : 2 (2015), p. 435-446. -
További szerzők:Kristóf Endre (1987-) (általános orvos) Zahuczky Gábor (1975-) (molekuláris biológus, biokémikus, vegyész) Szatmári-Tóth Mária (1987-) (molekuláris biológus) Veréb Zoltán (1980-) (immunológus, mikrobiológus, molekuláris biológus) Oláh Brigitta Moe, Morten C. Facskó Andrea (1953-) (szemész) Fésüs László (1947-) (orvos biokémikus) Petrovski, Goran (1975-) (orvos)
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2.

001-es BibID:BIBFORM013626
Első szerző:Fodor Mariann (szemész)
Cím:Spectroscopic study of explanted opacified hydrophilic acrylic intraocular lenses / Fodor M., Petrovski G., Moe M. C., Bíró Z., Németh G., Dinya Z., Tornai I., Ujvári T., Berta A., Facskó A.
Dátum:2011
ISSN:1755-3768
Megjegyzések:To report a detailed spectroscopic analysis of explanted hydrophilic acrylic intraocular lenses (IOLs) that were removed because of postoperative opacification of the lens optic. Methods: Thirteen Hydroview H60M (Bausch & Lomb Surgical) IOLs were explanted from 13 different patients on average 56 months after phacoemulsification and IOL implantation. All patients had decreased visual acuity because of a fine granularity of the optical surface of the IOLs. The surface was investigated by gross, microscopic, histochemical and scanning electron microscopic analysis, and the elemental composition of the opacified IOLs was determined by X-ray fluorescence spectroscopy (XRF). The spectrograms were compared to three different originally packed and never-implanted hydrophilic acrylic IOLs. Results: Light and scanning electron microscopy of the optical surface of explanted IOLs revealed multiple fine granular deposits varying in size and shape that were positive for alizarin red. XRF confirmed that the explanted IOLs contained not only the previously reported calcium and phosphorous (calcium apatite), chlorine, silicone, sodium, aluminum and magnesium but also iron, sulfur, potassium as well as lesser amounts of iodine, zinc, strontium and yttrium. Conclusion: This is the first spectroscopic analysis determining the content of more than 10 elements of explanted and originally packed never-implanted hydrophilic acrylic IOLs. The possible origin of the different elements obtained from the spectrograms and their implications are discussed.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Acta Ophthalmologica. - 89 : 2 (2011), p. e161-e166. -
További szerzők:Petrovski, Goran (1975-) (orvos) Moe, Morten C. Biró Zsolt (szemész) Németh Gábor (1975-) (szemész) Dinya Zoltán (1942-) (vegyész) Tornai Ildikó Ujvári Tamás Berta András (1955-) (szemész, gyermekszemész) Facskó Andrea (1953-) (szemész)
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3.

001-es BibID:BIBFORM059505
Első szerző:Froen, Rebecca C.
Cím:Does the Adult Human Ciliary Body Epithelium Contain "True" Retinal Stem Cells? / Froen Rebecca, Johnsen Erik O., Nicolaissen Bjorn, Facskó Andrea, Petrovski Goran, Moe Morten C.
Dátum:2013
ISSN:2314-6133 2314-6141
Megjegyzések:Recent reports of retinal stem cells being present in several locations of the adult eye have sparked great hopes that they may be used to treat the millions of people worldwide who suffer from blindness as a result of retinal disease or injury. A population of proliferative cells derived from the ciliary body epithelium (CE) has been considered one of the prime stem cell candidates, and as such they have received much attention in recent years. However, the true nature of these cells in the adult human eye has still not been fully elucidated, and the stem cell claim has become increasingly controversial in light of new and conflicting reports. In this paper, we will try to answer the question of whether the available evidence is strong enough for the research community to conclude that the adult human CE indeed harbors stem cells.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
NEURAL PROGENITOR CELLS
MAMMALIAN EYE
HUMAN BRAIN
PROLIFERATIVE VITREORETINOPATHY
STEM/PROGENITOR CELLS
NEUROSPHERE ASSAY
DIFFERENTIATION
SYSTEM
PHOTORECEPTORS
IDENTIFICATION
Megjelenés:Biomed Research International. - 2013 : Article ID 531579 (2013), p. 1-7. -
További szerzők:Johnsen, Erik O. Nicolaissen, Bjorn Facskó Andrea (1953-) (szemész) Petrovski, Goran (1975-) (orvos) Moe, Morten C.
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4.

001-es BibID:BIBFORM037061
Első szerző:Froen, Rebecca C.
Cím:Pigment epithelial cells isolated from human peripheral iridectomies have limited properties of retinal stem cells / Froen R. C., Johnsen E. O., Petrovski G., Berényi E., Facskó A., Berta A., Nicolaissen B., Moe M. C.
Dátum:2011
ISSN:1755-375X
Megjegyzések:PURPOSE: The identification of cells with properties of retinal progenitor cells (RPCs) in the adult human ciliary margin (CM) prompted a number of studies of their proliferative and differentiation potential. One of the remaining challenges is to find a feasible method of isolating RPCs from the patient's eye. In the human CM, only the iris pigment epithelium (IPE) is easily obtained by a minimally invasive procedure. In the light of recent studies questioning the existence of RPCs in the adult mammalian CM, we wanted to assess the potential of the adult human IPE as source of RPCs. METHODS: The IPE were isolated from peripheral iridectomies during glaucoma surgery, and IPE and ciliary body (CB) epithelium were also isolated from post-mortem tissue. Cells were cultivated in sphere-promoting conditions or as monolayers. Whole-tissue samples, undifferentiated and differentiated cells were studied by immunocytochemistry, RT-PCR and transmission electron microscopy. RESULTS: The adult human IPE, like the CB, expressed markers of RPCs such as Pax6, Sox2 and Nestin in vivo. Both sphere-promoting and monolayer cultures preserved this phenotype. However, both IPE/CB cultures expressed markers of differentiated epithelial cells such as Claudin, microphtalmia-associated transcription factor (MITF) and Cytokeratin-19. Ultrastructurally, IPE spheres displayed epithelial-like junctions and contained mature melanosomes. After induced differentiation, IPE-derived cells showed only partial neuronal differentiation expressing beta-III-tubulin, Map-2 and Rhodopsin, whereas no mature glial markers were found. CONCLUSION: Proliferative cells with some properties of RPCs can be isolated from the adult human IPE by peripheral iridectomies. Yet, many cells retain properties of differentiated epithelial cells and lack central properties of somatic stem cells.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Ophthalmologica. - 89 : 8 (2011), p. 635-644. -
További szerzők:Johnsen, Erik O. Petrovski, Goran (1975-) (orvos) Berényi Erika Facskó Andrea (1953-) (szemész) Berta András (1955-) (szemész, gyermekszemész) Nicolaissen, Bjorn Moe, Morten C.
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5.

001-es BibID:BIBFORM062340
Első szerző:Petrovski, Goran (orvos)
Cím:Herpes simplex virus types 1 and 2 modulate autophagy in SIRC corneal cells / Goran Petrovski, Kata Pásztor, László Orosz, Réka Albert, Edina Mencel, Morten C. Moe, Kai Kaarniranta, Andrea Facskó, Klára Megyeri
Dátum:2014
ISSN:0250-5991
Megjegyzések:Autophagy and apoptosis function as important early cellular defense mechanisms in infections and other diseases. The outcome of an infection is determined by a complex interplay between the pathogenic microorganism and these intracellular pathways. To better understand the cytopathogenicity of Herpes simplex virus types 1 and 2 (HSV-1 and - 2), we studied the effect of these viruses on the autophagic and apoptotic processes in the SIRC corneal cell line. Infection with the KOS strain of HSV-1 and a wild-type strain of HSV-2 enhanced autophagosome formation, triggered cytoplasmic acidification, increased LC3B lipidation and elevated the ratio of apoptotic cells. The autophagy inhibitor bafilomycin A1 triggered a significant increase in the apoptotic responses of HSV-1 and HSV-2-infected cells. Thus, both HSV types affect autophagy and apoptosis in a coordinated fashion, and autophagy plays cytoprotective role in HSV-infected cells via antagonizing apoptosis. Together these data implicate autophagy in the pathogenic mechanism of herpetic keratitis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Apoptosis
autophagy
corneal cells
Herpes simplex virus
keratitis
Megjelenés:Journal Of Biosciences. - 39 : 4 (2014), p. 683-692. -
További szerzők:Pásztor Kata Orosz László (Szeged) Albert Réka (1986-) Mencel Edina Moe, Morten C. Kaarniranta, Kai (1972-) (szemész szakorvos) Facskó Andrea (1953-) (szemész) Megyeri Klára
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6.

001-es BibID:BIBFORM028036
Első szerző:Petrovski, Goran (orvos)
Cím:Clearance of dying ARPE-19 cells by professional and nonprofessional phagocytes in vitro- implications for age-related macular degeneration (AMD) / Petrovski Goran, Berényi Erika, Moe Morten C., Vajas Attila, Fésüs László, Berta András, Facskó Andrea
Dátum:2011
ISSN:1755-375X
Megjegyzések:Failure of retinal pigment epithelial (RPE) cells and macrophages to engulf different dying cells in the retina may result in accumulation of debris and development of age-related macular degeneration (AMD). The dynamics and influence of different treatments on this clearance process can be studied in vitro using human ARPE-19 cells and macrophages as phagocytes modelling dry and wet type of AMD, respectively. METHODS: Death through extracellular matrix detachment using polyHEMA-coated surfaces (anoikis) and UV irradiation (apoptosis) was induced in ARPE-19 cells. Two-coloured phagocytic assays were performed to quantify the amount of dying cells phagocytes engulfed (flow cytometry) and for visualization (fluorescent and scanning electron microscopy). The effect of phosphatidylserine inhibition with recombinant annexin-V and glucocorticoid (triamcinolone) treatment on the phagocytic process was tested. RESULTS: The clearance of anoikic and apoptotic cells by nondying ARPE-19 cells over 8 hr of co-incubation increased over time (at 8 hr, over 53% and 35% of the phagocytes contained engulfed dying cells, respectively). The human macrophages engulfed the anoikic and apoptotic ARPE-19 cells with seven and four times lower capacity, respectively. Phosphatidylserine appearance on the dying cells did not affect, but triamcinolone treatment enhanced the phagocytosis of the dying cells by macrophages. CONCLUSIONS: ARPE-19 cells are more efficient in clearing anoikic than UV-induced apoptotic cells. Macrophages are less efficient in the clearance process than ARPE-19 cells. The present model can be used for studying both dry and wet type of AMD in vitro and for testing different pharmacological aspects affecting this disease.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Ophthalmologica. - 89 : 1 (2011), p. 30-34. -
További szerzők:Berényi Erika Moe, Morten C. Vajas Attila (1973-) (szemész) Fésüs László (1947-) (orvos biokémikus) Berta András (1955-) (szemész, gyermekszemész) Facskó Andrea (1953-) (szemész)
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7.

001-es BibID:BIBFORM064011
035-os BibID:(Cikkazonosító)26227 (WOS)000376370500001 (Scopus)84970028330
Első szerző:Veréb Zoltán (immunológus, mikrobiológus, molekuláris biológus)
Cím:Role of Human Corneal Stroma-Derived Mesenchymal-Like Stem Cells in Corneal Immunity and Wound Healing / Zoltán Veréb, Szilárd Póliska, Réka Albert, Ole Kristoffer Olstad, Anita Boratkó, Csilla Csortos, Morten C. Moe, Andrea Facskó, Goran Petrovski
Dátum:2016
ISSN:2045-2322
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 6 : 26227 (2016), p. 1-17. -
További szerzők:Póliska Szilárd (1978-) (biológus) Albert Réka (1986-) Olstad, Ole Kristoffer Boratkó Anita (1985-) (biokémikus, molekuláris biológus) Csortos Csilla (1956-) (biokémikus) Moe, Morten C. Facskó Andrea (1953-) (szemész) Petrovski, Goran (1975-) (orvos)
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