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001-es BibID:	BIBFORM053600
035-os BibID:	Article ID: 768026
Első szerző:	Blasiak, Janusz
Cím:	Oxidative stress, hypoxia, and autophagy in the neovascular processes of age-related macular degeneration / Janus Blasiak, Goran Petrovski, Zoltán Veréb, Andrea Facskó, Kai Kaarniranta
Dátum:	2014
ISSN:	2314-6133 2314-6141
Megjegyzések:	Age-related macular degeneration (AMD) is the leading cause of severe and irreversible loss of vision in the elderly in developed countries. AMD is a complex chronic neurodegenerative disease associated with many environmental, lifestyle, and genetic factors. Oxidative stress and the production of reactive oxygen species (ROS) seem to play a pivotal role in AMD pathogenesis. It is known that the macula receives the highest blood flow of any tissue in the body when related to size, and anything that can reduce the rich blood supply can cause hypoxia, malfunction, or disease. Oxidative stress can affect both the lipid rich retinal outer segment structure and the light processing in the macula. The response to oxidative stress involves several cellular defense reactions, for example, increases in antioxidant production and proteolysis of damaged proteins. The imbalance between production of damaged cellular components and degradation leads to the accumulation of detrimental products, for example, intracellular lipofuscin and extracellular drusen. Autophagy is a central lysosomal clearance system that may play an important role in AMD development. There are many anatomical changes in retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillaris in response to chronic oxidative stress, hypoxia, and disturbed autophagy and these are estimated to be crucial components in the pathology of neovascular processes in AMD.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	BioMed Research International. - 2014 (2014), [8] p. -
További szerzők:	Petrovski, Goran (1975-) (orvos) Veréb Zoltán (1980-) (immunológus, mikrobiológus, molekuláris biológus) Facskó Andrea (1953-) (szemész) Kaarniranta, Kai (1972-) (szemész szakorvos)
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001-es BibID:	BIBFORM062340
Első szerző:	Petrovski, Goran (orvos)
Cím:	Herpes simplex virus types 1 and 2 modulate autophagy in SIRC corneal cells / Goran Petrovski, Kata Pásztor, László Orosz, Réka Albert, Edina Mencel, Morten C. Moe, Kai Kaarniranta, Andrea Facskó, Klára Megyeri
Dátum:	2014
ISSN:	0250-5991
Megjegyzések:	Autophagy and apoptosis function as important early cellular defense mechanisms in infections and other diseases. The outcome of an infection is determined by a complex interplay between the pathogenic microorganism and these intracellular pathways. To better understand the cytopathogenicity of Herpes simplex virus types 1 and 2 (HSV-1 and - 2), we studied the effect of these viruses on the autophagic and apoptotic processes in the SIRC corneal cell line. Infection with the KOS strain of HSV-1 and a wild-type strain of HSV-2 enhanced autophagosome formation, triggered cytoplasmic acidification, increased LC3B lipidation and elevated the ratio of apoptotic cells. The autophagy inhibitor bafilomycin A1 triggered a significant increase in the apoptotic responses of HSV-1 and HSV-2-infected cells. Thus, both HSV types affect autophagy and apoptosis in a coordinated fashion, and autophagy plays cytoprotective role in HSV-infected cells via antagonizing apoptosis. Together these data implicate autophagy in the pathogenic mechanism of herpetic keratitis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Apoptosis autophagy corneal cells Herpes simplex virus keratitis
Megjelenés:	Journal Of Biosciences. - 39 : 4 (2014), p. 683-692. -
További szerzők:	Pásztor Kata Orosz László (Szeged) Albert Réka (1986-) Mencel Edina Moe, Morten C. Kaarniranta, Kai (1972-) (szemész szakorvos) Facskó Andrea (1953-) (szemész) Megyeri Klára
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001-es BibID:	BIBFORM064981
Első szerző:	Szatmári-Tóth Mária (molekuláris biológus)
Cím:	Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration / Szatmári-Tóth Mária, Kristóf Endre, Veréb Zoltán, Saeed Akhtar, Facskó Andrea, Fésüs László, Anu Kauppinen, Kai Kaarniranta, Goran Petrovski
Dátum:	2016
ISSN:	2041-4889
Megjegyzések:	Retinal pigment epithelial (RPE) cells can undergo different forms of cell death, including autophagy-associated cell death during age-related macular degeneration (AMD). Failure of macrophages or dendritic cells (DCs) to engulf the different dying cells in the retina may result in accumulation of debris and progression of AMD. ARPE-19 and primary human RPE cells undergo autophagy-associated cell death upon serum depletion and oxidative stress induced by hydrogen peroxide (H2O2). Autophagy was revealed by elevated light-chain-3 II (LC3 II) expression and electron microscopy, while autophagic flux was confirmed by blocking the autophago-lysosomal fusion using chloroquine (CQ) in these cells. The autophagy-associated dying RPE cells were engulfed by human macrophages, DCs and living RPE cells in an increasing and time-dependent manner. Inhibition of autophagy by 3-methyladenine (3-MA) decreased the engulfment of the autophagy-associated dying cells by macrophages, while sorting out the GFP-LC3 positive/autophagic cell population or treatment by the glucocorticoid triamcinolone (TC) enhanced it. Increased amounts of IL-6 and IL-8 were released when autophagy-associated dying RPEs were engulfed by macrophages. Our data suggest that cells undergoing autophagy-associated cell death engage in clearance mechanisms guided by professional and non-professional phagocytes, which is accompanied by inflammation as part of an in vitro modelling of AMD pathogenesis.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban autofágia, fagicitózis, makrofágok, triamcinolone, gyulladás, időskori makula degeneráció
Megjelenés:	Cell Death & Disease 7 : 9 (2016), p. e2367. -
További szerzők:	Kristóf Endre (1987-) (általános orvos) Veréb Zoltán (1980-) (immunológus, mikrobiológus, molekuláris biológus) Akhtar, Saeed (1949-) (molekuláris biológus) Facskó Andrea (1953-) (szemész) Fésüs László (1947-) (orvos biokémikus) Kauppinen, Anu (1977-) (sejtbiológus) Kaarniranta, Kai (1972-) (szemész szakorvos) Petrovski, Goran (1975-) (szemész szakorvos)
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