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001-es BibID:	BIBFORM053600
035-os BibID:	Article ID: 768026
Első szerző:	Blasiak, Janusz
Cím:	Oxidative stress, hypoxia, and autophagy in the neovascular processes of age-related macular degeneration / Janus Blasiak, Goran Petrovski, Zoltán Veréb, Andrea Facskó, Kai Kaarniranta
Dátum:	2014
ISSN:	2314-6133 2314-6141
Megjegyzések:	Age-related macular degeneration (AMD) is the leading cause of severe and irreversible loss of vision in the elderly in developed countries. AMD is a complex chronic neurodegenerative disease associated with many environmental, lifestyle, and genetic factors. Oxidative stress and the production of reactive oxygen species (ROS) seem to play a pivotal role in AMD pathogenesis. It is known that the macula receives the highest blood flow of any tissue in the body when related to size, and anything that can reduce the rich blood supply can cause hypoxia, malfunction, or disease. Oxidative stress can affect both the lipid rich retinal outer segment structure and the light processing in the macula. The response to oxidative stress involves several cellular defense reactions, for example, increases in antioxidant production and proteolysis of damaged proteins. The imbalance between production of damaged cellular components and degradation leads to the accumulation of detrimental products, for example, intracellular lipofuscin and extracellular drusen. Autophagy is a central lysosomal clearance system that may play an important role in AMD development. There are many anatomical changes in retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillaris in response to chronic oxidative stress, hypoxia, and disturbed autophagy and these are estimated to be crucial components in the pathology of neovascular processes in AMD.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	BioMed Research International. - 2014 (2014), [8] p. -
További szerzők:	Petrovski, Goran (1975-) (orvos) Veréb Zoltán (1980-) (immunológus, mikrobiológus, molekuláris biológus) Facskó Andrea (1953-) (szemész) Kaarniranta, Kai (1972-) (szemész szakorvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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