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001-es BibID:	BIBFORM039775
035-os BibID:	PMID:12239055
Első szerző:	Szűcs-Farkas Zsolt
Cím:	Using morphologic parameters of extraocular muscles for diagnosis and follow-up of Graves' ophthalmopathy : diameters, areas, or volumes? / Zsolt Szucs-Farkas, Judit Toth, Erzsebet Balazs, Laszlo Galuska, Kenneth D. Burman, Zsolt Karanyi, Andras Leovey, Endre V. Nagy
Dátum:	2002
Megjegyzések:	OBJECTIVE: The objective of this study was to find the most appropriate, accurate, and convenient muscle parameter that can be used as a substitute for volume in monitoring the effectiveness of therapy of patients with Graves' ophthalmopathy. SUBJECTS AND METHODS: The four rectus muscles in 110 orbits (35 patients and 20 control subjects) were evaluated with MR imaging. The diameter at the largest extent of the muscle belly, as well as the long and the short diameters and the cross-sectional areas in a preselected coronal scan, were measured for each muscle and were compared with the corresponding muscle volume measured on contiguous T1-weighted transverse slices. RESULTS: The measured coronal area correlated well with the volume of the superior (r = 0.694, p < 0.0001) and inferior (r = 0.783, p < 0.0001) recti, and the largest transverse diameter showed strong correlation with the volume of the lateral (r = 0.868, p < 0.0001) and medial (r = 0.869, p < 0.0001) recti. For the latter muscle, the coronal area also exhibited a good correlation with the volume (r = 0.838, p < 0.0001). Coronal cross-sectional areas can be well estimated by measuring both the short and long coronal muscle diameters (r values were between 0.914 and 0.966; p < 0.0001). CONCLUSION: In Graves' ophthalmopathy, the volume of three of the rectus muscles can be well estimated by simple measurements on a single coronal slice, and the largest transverse diameter of the lateral rectus is suitable for the same purpose.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	AJR, American Journal of Roentgenology 179 : 4 (2002), p. 1005-1010. -
További szerzők:	Tóth Judit (1964-) (radiológus) Balázs Erzsébet (1952-) (szemész) Galuska László (1946-) (belgyógyász, izotópdiagnoszta) Burman, Kenneth D. Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Leövey András (1926-) (belgyógyász) Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM029177
Első szerző:	Ujhelyi Bernadett (szemész)
Cím:	Retrobulbar 99mTc-diethylenetriamine-pentaacetic-acid uptake may predict the effectiveness of immunosuppressive therapy in Graves' ophthalmopathy / Bernadett Ujhelyi, Annamaria Erdei, Laszlo Galuska, Jozsef Varga, Lajos Szabados, Erzsebet Balazs, Miklos Bodor, Bela Cseke, Zsolt Karanyi, Andras Leovey, Emese Mezosi, Kenneth D. Burman, Andras Berta, Endre V. Nagy
Dátum:	2009
ISSN:	1050-7256
Megjegyzések:	Background: In Graves' ophthalmopathy (GO), only patients with immunologically active disease respond toimmunosuppressive therapy. Previous studies and theoretical considerations suggest that elevated orbital 99mTcdiethylenetriamine-pentaacetic-acid (DTPA) single photon emission computed tomography (SPECT) reflectsinflammatory disease activity. We studied whether corticosteroid treatment causes a substantial decrease inDTPA uptake in GO, a result consistent with successful immunosuppressive treatment of GO and referred to asa favorable treatment outcome.Methods: One hundred fourteen orbits in 57 patients with active GO (CAS?4) were entered into the study. Allpatients received corticosteroid treatment. Orbital DTPA uptakes were numerically quantified for the entire orbitas well as the anterior and posterior segments separately. DTPA SPECT was performed before, and 2 to 9months after the initiation of immunosuppressive treatment. The normal range for DTPA uptake was establishedin 34 orbits of 17 patients who were being worked up for Raynaud's phenomenon and had no thyroiddisease.Results: The mean DTPA uptake of the 114 orbits of GO patients was higher prior to corticosteroid therapy thanafter this treatment (11.03?4.26MBq/cm3 and 9.84?3.51MBq/cm3, respectively, p<0.001) but a substantialdecline in DTPA uptake was seen in only 39.5% of GO patients. The positive predictive value of an initialDTPA >12.28MBq/cm3 for a substantial decline in DTPA uptake (favorable treatment outcome) was 76%, whilea negative predictive value of a pretreatment DTPA?12.28MBq/cm3 was 78%.Conclusions: Corticosteriod treatment is associated with a decline in DTPA uptake in a fraction of GO patients.GO patients with a DTPA uptake above 12.28MBq/cm3 are more likely to have a favorable response to corticosteroidtherapy while patients with lower values are less likely to have this potentially favorable response.An elevated DTPA uptake may identify patients who are most likely to benefit from immunosuppressivetreatment.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Graves' orbitopathy immunological activity DTPA SPECT egyetemen (Magyarországon) készült közlemény
Megjelenés:	Thyroid. - 19 : 4 (2009), p. 375-380. -
További szerzők:	Erdei Annamária (1976-) (belgyógyász) Galuska László (1946-) (belgyógyász, izotópdiagnoszta) Varga József (1955-) (fizikus) Szabados Lajos (1977-) (orvos) Balázs Erzsébet (1952-) (szemész) Bodor Miklós (1969-) (belgyógyász, endokrinológus) Cseke Béla (1974-) (belgyógyász, endokrinológus) Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Leövey András (1926-) (belgyógyász) Mezősi Emese Burman, Kenneth D. Berta András (1955-) (szemész, gyermekszemész) Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
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